ENSMUSG00000004113


Mus musculus

Features
Gene ID: ENSMUSG00000004113
  
Biological name :Cacna1b
  
Synonyms : Cacna1b / O55017 / Voltage-dependent N-type calcium channel subunit alpha-1B
  
Possible biological names infered from orthology : calcium voltage-gated channel subunit alpha1 B / Q00975
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 24603887
Gene end: 24763152
  
Corresponding Affymetrix probe sets: 10480492 (MoGene1.0st)   1425812_a_at (Mouse Genome 430 2.0 Array)   1436602_x_at (Mouse Genome 430 2.0 Array)   1439612_at (Mouse Genome 430 2.0 Array)   1460608_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100003
Ensembl peptide - ENSMUSP00000097920
Ensembl peptide - ENSMUSP00000110090
Ensembl peptide - ENSMUSP00000141767
Ensembl peptide - ENSMUSP00000141653
Ensembl peptide - ENSMUSP00000116674
Ensembl peptide - ENSMUSP00000115285
Ensembl peptide - ENSMUSP00000114605
Ensembl peptide - ENSMUSP00000037416
Ensembl peptide - ENSMUSP00000063236
NCBI entrez gene - 12287     See in Manteia.
MGI - MGI:88296
RefSeq - XM_017315156
RefSeq - XM_006497633
RefSeq - XM_006497634
RefSeq - XM_006497635
RefSeq - XM_006497636
RefSeq - XM_006497637
RefSeq - XM_006497638
RefSeq - XM_006497640
RefSeq - XM_017315140
RefSeq - XM_017315141
RefSeq - XM_017315146
RefSeq - XM_017315155
RefSeq - NM_001042528
RefSeq - NM_007579
RefSeq - XM_006497626
RefSeq - XM_006497627
RefSeq - XM_006497628
RefSeq - XM_006497629
RefSeq - XM_006497630
RefSeq - XM_006497631
RefSeq - XM_006497632
RefSeq Peptide - NP_001035993
RefSeq Peptide - NP_031605
swissprot - A2AIS0
swissprot - A2AIR9
swissprot - A2AIR7
swissprot - A2AJ01
swissprot - A0A0A6YWZ5
swissprot - O55017
swissprot - A0A0A6YWR0
swissprot - F7C9S8
swissprot - A2AIZ9
Ensembl - ENSMUSG00000004113
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna1baENSDARG00000021735Danio rerio
 cacna1bbENSDARG00000079295Danio rerio
 CACNA1BENSGALG00000008456Gallus gallus
 Q00975ENSG00000148408Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97445 / Cacna1a / Voltage-dependent P/Q-type calcium channel subunit alpha-1A / O00555* / calcium voltage-gated channel subunit alpha1 A*ENSMUSG0000003465663
Cacna1e / calcium voltage-gated channel subunit alpha1 E / Q15878*ENSMUSG0000000411056
Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*ENSMUSG0000001596836
Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*ENSMUSG0000005133136
Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*ENSMUSG0000002640733
Cacna1f / calcium voltage-gated channel subunit alpha1 F / O60840*ENSMUSG0000003114233
Nalcn / sodium leak channel, non-selective / Q8IZF0*ENSMUSG0000000019716
Q91ZR5 / Catsper1 / Cation channel sperm-associated protein 1 / Q8NEC5* / cation channel sperm associated 1*ENSMUSG000000384986


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005447  Voltage-dependent calcium channel, N-type, alpha-1 subunit
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007269 neurotransmitter secretion IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0051924 regulation of calcium ion transport IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Bmpertm1Cpat/Bmper+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Bmpertm1Cpat/Bmper+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001752 abnormal hypothalamus secretion "altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmpertm1Cpat/Bmper+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1btm1.1Dili/Cacna1btm1.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpertm1Cpat/Bmper+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpertm1Cpat/Bmper+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmpertm1Cpat/Bmper+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002570 alcohol aversion 
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Allelic Composition: Bmpertm1Cpat/Bmper+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002802 abnormal discrimination learning "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002969 impaired social transmission of food preference "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0003194 abnormal frequency of paradoxical sleep "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cacna1btm1.1Dili/Cacna1btm1.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003470 abnormal summary potential "anomaly in the electrophysiological recording of the activity of several cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004184 abnormal baroreceptor physiology "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cacna1btm1Ksw/Cacna1btm1Ksw
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009436 fragmentation of sleep/wake states "short bouts of sleep/wake stages with an increased number of transitions among these stages compared to controls" [PMID:19246384]
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Allelic Composition: Cacna1btm1Ksw/Cacna1btm1Ksw
Genetic Background: involves: C57BL/6 * CBA

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

 MP:0009751 enhanced behavioral response to alcohol "increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009755 impaired behavioral response to alcohol "decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1btm1Hssh/Cacna1btm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cacna1btm1.1Dili/Cacna1btm1.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Acvr1ctm1Cfi/Acvr1c+,Gdf1tm1Sjl/Gdf1+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129 * C57BL/6

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003352 Cacnb3 / P54285 / Mus musculus calcium channel, voltage-dependent, beta 3 subunit (Cacnb3), transcript variant 4, mRNA. / P54284* / calcium voltage-gated channel auxiliary subunit beta 3*  / complex
 ENSMUSG00000019146 Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit / Q9Y698* / calcium voltage-gated channel auxiliary subunit gamma 2*  / complex






 

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