ENSMUSG00000038498


Mus musculus

Features
Gene ID: ENSMUSG00000038498
  
Biological name :Catsper1
  
Synonyms : Cation channel sperm-associated protein 1 / Catsper1 / Q91ZR5
  
Possible biological names infered from orthology : cation channel sperm associated 1 / Q8NEC5
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 5335741
Gene end: 5344153
  
Corresponding Affymetrix probe sets: 10460560 (MoGene1.0st)   1426281_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045430
NCBI entrez gene - 225865     See in Manteia.
MGI - MGI:2179947
RefSeq - XM_017318141
RefSeq - NM_139301
RefSeq - XM_006531708
RefSeq Peptide - NP_647462
swissprot - Q91ZR5
Ensembl - ENSMUSG00000038498
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8NEC5ENSG00000175294Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97445 / Cacna1a / Voltage-dependent P/Q-type calcium channel subunit alpha-1A / O00555* / calcium voltage-gated channel subunit alpha1 A*ENSMUSG0000003465621
Cacna1e / calcium voltage-gated channel subunit alpha1 E / Q15878*ENSMUSG0000000411020
O55017 / Cacna1b / Voltage-dependent N-type calcium channel subunit alpha-1B / Q00975* / calcium voltage-gated channel subunit alpha1 B*ENSMUSG0000000411320
Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*ENSMUSG0000005133120
Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*ENSMUSG0000001596819
Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*ENSMUSG0000002640719
Cacna1f / calcium voltage-gated channel subunit alpha1 F / O60840*ENSMUSG0000003114218
Nalcn / sodium leak channel, non-selective / Q8IZF0*ENSMUSG0000000019712


Protein motifs (from Interpro)
Interpro ID Name
 IPR005821  Ion transport domain
 IPR028746  Cation channel sperm-associated protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051924 regulation of calcium ion transport IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060296 regulation of cilium beat frequency involved in ciliary motility IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0036128 CatSper complex IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005227 calcium activated cation channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IMP
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IBA


Pathways (from Reactome)
Pathway description
Sperm Motility And Taxes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Catsper2tm1Gar/Catsper2tm1Gar
Genetic Background: involves: 129S6/SvEvTac

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Catsper1tm1Clph/Catsper1tm1Clph,Lrrc52tm1.1(KOMP)Vlcg/Lrrc52tm1.1(KOMP)Vlcg
Genetic Background: involves: 129S4/SvJae * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021499 Q80W99 / Catsper3 / Cation channel sperm-associated protein 3 / Q86XQ3* / cation channel sperm associated 3*  / complex
 ENSMUSG00000038498 Q91ZR5 / Catsper1 / Cation channel sperm-associated protein 1 / Q8NEC5* / cation channel sperm associated 1*  / complex
 ENSMUSG00000033486 Catsper2 / Q96P56* / AC011330.3* / cation channel sperm associated 2*  / complex
 ENSMUSG00000049676 E9Q355 / Catsperg1 / Cation channel sperm-associated protein subunit gamma 1 / Q6ZRH7* / CATSPERG* / cation channel sperm associated auxiliary subunit gamma*  / complex
 ENSMUSG00000048003 Q8BVN3 / Catsper4 / Cation channel sperm-associated protein 4 / Q7RTX7* / cation channel sperm associated 4*  / complex
 ENSMUSG00000047014 A2RTF1 / Catsperb / Cation channel sperm-associated protein subunit beta / Q9H7T0* / cation channel sperm associated auxiliary subunit beta*  / complex
 ENSMUSG00000049123 C6KI89 / Catsperg2 / Cation channel sperm-associated protein subunit gamma 2 / Q6ZRH7* / CATSPERG* / cation channel sperm associated auxiliary subunit gamma*  / complex
 ENSMUSG00000040828 E9Q9F6 / Catsperd / Cation channel sperm-associated protein subunit delta / Q86XM0* / cation channel sperm associated auxiliary subunit delta*  / complex






 

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