ENSMUSG00000021499


Mus musculus

Features
Gene ID: ENSMUSG00000021499
  
Biological name :Catsper3
  
Synonyms : Cation channel sperm-associated protein 3 / Catsper3 / Q80W99
  
Possible biological names infered from orthology : cation channel sperm associated 3 / Q86XQ3
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 55784568
Gene end: 55808998
  
Corresponding Affymetrix probe sets: 10405552 (MoGene1.0st)   1432146_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021961
Ensembl peptide - ENSMUSP00000105524
NCBI entrez gene - 76856     See in Manteia.
MGI - MGI:1924106
RefSeq - XM_006517455
RefSeq - NM_001252487
RefSeq - NM_001252488
RefSeq - NM_029772
RefSeq Peptide - NP_001239416
RefSeq Peptide - NP_001239417
RefSeq Peptide - NP_084048
swissprot - Q80W99
swissprot - E0Z0E0
Ensembl - ENSMUSG00000021499
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q86XQ3ENSG00000152705Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BVN3 / Catsper4 / Cation channel sperm-associated protein 4 / Q7RTX7* / cation channel sperm associated 4*ENSMUSG0000004800319


Protein motifs (from Interpro)
Interpro ID Name
 IPR005821  Ion transport domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IMP
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0048240 sperm capacitation IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0036128 CatSper complex IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IMP
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Sperm Motility And Taxes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pdgfratm6Sor/Pdgfratm6Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm6Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Catsper3tm1Wyan/Catsper3tm1Wyan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Catsper3tm1.1(KOMP)Vlcg/Catsper3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Catsper3tm1.1(KOMP)Vlcg/Ucd

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdgfratm6Sor/Pdgfratm6Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm6Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Catsper3tm1Wyan/Catsper3tm1Wyan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfratm6Sor/Pdgfratm6Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm6Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0003666 impaired sperm capacitation "anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96669]
Show

Allelic Composition: Pdgfratm6Sor/Pdgfratm6Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm6Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm6Sor/Pdgfratm6Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm6Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfratm6Sor/Pdgfratm6Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm6Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021499 Q80W99 / Catsper3 / Cation channel sperm-associated protein 3 / Q86XQ3* / cation channel sperm associated 3*  / complex
 ENSMUSG00000038498 Q91ZR5 / Catsper1 / Cation channel sperm-associated protein 1 / Q8NEC5* / cation channel sperm associated 1*  / complex
 ENSMUSG00000033486 Catsper2 / Q96P56* / AC011330.3* / cation channel sperm associated 2*  / complex
 ENSMUSG00000049676 E9Q355 / Catsperg1 / Cation channel sperm-associated protein subunit gamma 1 / Q6ZRH7* / CATSPERG* / cation channel sperm associated auxiliary subunit gamma*  / complex
 ENSMUSG00000048003 Q8BVN3 / Catsper4 / Cation channel sperm-associated protein 4 / Q7RTX7* / cation channel sperm associated 4*  / complex
 ENSMUSG00000047014 A2RTF1 / Catsperb / Cation channel sperm-associated protein subunit beta / Q9H7T0* / cation channel sperm associated auxiliary subunit beta*  / complex
 ENSMUSG00000049123 C6KI89 / Catsperg2 / Cation channel sperm-associated protein subunit gamma 2 / Q6ZRH7* / CATSPERG* / cation channel sperm associated auxiliary subunit gamma*  / complex
 ENSMUSG00000040828 E9Q9F6 / Catsperd / Cation channel sperm-associated protein subunit delta / Q86XM0* / cation channel sperm associated auxiliary subunit delta*  / complex






 

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