ENSMUSG00000051331


Mus musculus

Features
Gene ID: ENSMUSG00000051331
  
Biological name :Cacna1c
  
Synonyms : Cacna1c / Q01815 / Voltage-dependent L-type calcium channel subunit alpha-1C
  
Possible biological names infered from orthology : calcium voltage-gated channel subunit alpha1 C / Q13936
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 118587240
Gene end: 119196418
  
Corresponding Affymetrix probe sets: 10547322 (MoGene1.0st)   1421297_a_at (Mouse Genome 430 2.0 Array)   1435730_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139981
Ensembl peptide - ENSMUSP00000139855
Ensembl peptide - ENSMUSP00000140056
Ensembl peptide - ENSMUSP00000151863
Ensembl peptide - ENSMUSP00000151462
Ensembl peptide - ENSMUSP00000151458
Ensembl peptide - ENSMUSP00000151391
Ensembl peptide - ENSMUSP00000141033
Ensembl peptide - ENSMUSP00000141015
Ensembl peptide - ENSMUSP00000140961
Ensembl peptide - ENSMUSP00000140920
Ensembl peptide - ENSMUSP00000140886
Ensembl peptide - ENSMUSP00000140833
Ensembl peptide - ENSMUSP00000140693
Ensembl peptide - ENSMUSP00000140415
Ensembl peptide - ENSMUSP00000140341
Ensembl peptide - ENSMUSP00000140220
Ensembl peptide - ENSMUSP00000075021
Ensembl peptide - ENSMUSP00000077433
Ensembl peptide - ENSMUSP00000108410
Ensembl peptide - ENSMUSP00000108413
Ensembl peptide - ENSMUSP00000108444
NCBI entrez gene - 12288     See in Manteia.
MGI - MGI:103013
RefSeq - XM_017321369
RefSeq - XM_006505434
RefSeq - XM_006505435
RefSeq - XM_006505436
RefSeq - XM_006505437
RefSeq - XM_006505438
RefSeq - XM_006505439
RefSeq - XM_006505440
RefSeq - XM_006505441
RefSeq - XM_006505442
RefSeq - XM_006505443
RefSeq - XM_011241175
RefSeq - XM_011241176
RefSeq - XM_011241184
RefSeq - XM_011241185
RefSeq - XM_011241186
RefSeq - XM_011241187
RefSeq - XM_011241192
RefSeq - XM_011241193
RefSeq - XM_017321356
RefSeq - XM_017321357
RefSeq - XM_017321358
RefSeq - XM_017321359
RefSeq - XM_017321360
RefSeq - XM_017321361
RefSeq - XM_017321362
RefSeq - XM_017321363
RefSeq - XM_017321364
RefSeq - XM_017321365
RefSeq - XM_017321366
RefSeq - XM_017321367
RefSeq - XM_017321368
RefSeq - NM_001159533
RefSeq - NM_001159534
RefSeq - NM_001159535
RefSeq - NM_001255997
RefSeq - NM_001255998
RefSeq - NM_001255999
RefSeq - NM_001256000
RefSeq - NM_001256001
RefSeq - NM_001256002
RefSeq - NM_001290335
RefSeq - NM_009781
RefSeq - XM_006505415
RefSeq - XM_006505418
RefSeq - XM_006505426
RefSeq - XM_006505427
RefSeq - XM_006505430
RefSeq - XM_006505432
RefSeq Peptide - NP_001242929
RefSeq Peptide - NP_001242930
RefSeq Peptide - NP_001242931
RefSeq Peptide - NP_001277264
RefSeq Peptide - NP_033911
RefSeq Peptide - NP_001242926
RefSeq Peptide - NP_001242927
RefSeq Peptide - NP_001242928
RefSeq Peptide - NP_001153005
RefSeq Peptide - NP_001153006
RefSeq Peptide - NP_001153007
swissprot - A0A087WR02
swissprot - A0A087WQT9
swissprot - A0A087WQJ4
swissprot - F7C376
swissprot - C7TQ59
swissprot - A0A087WPZ8
swissprot - Q01815
swissprot - Q0PCR6
swissprot - A0A087WPP1
swissprot - F8WJL1
swissprot - C7TQ57
swissprot - A0A1W2P805
swissprot - A0A1W2P731
swissprot - A0A1W2P6Z7
swissprot - A0A1W2P6T3
swissprot - A0A087WSE7
swissprot - A0A087WS67
swissprot - A0A087WS40
swissprot - A0A087WRZ6
swissprot - A0A087WRM3
Ensembl - ENSMUSG00000051331
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna1cENSDARG00000008398Danio rerio
 CACNA1CENSGALG00000013022Gallus gallus
 Q13936ENSG00000151067Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*ENSMUSG0000001596865
Cacna1f / calcium voltage-gated channel subunit alpha1 F / O60840*ENSMUSG0000003114256
Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*ENSMUSG0000002640755
O55017 / Cacna1b / Voltage-dependent N-type calcium channel subunit alpha-1B / Q00975* / calcium voltage-gated channel subunit alpha1 B*ENSMUSG0000000411338
P97445 / Cacna1a / Voltage-dependent P/Q-type calcium channel subunit alpha-1A / O00555* / calcium voltage-gated channel subunit alpha1 A*ENSMUSG0000003465638
Cacna1e / calcium voltage-gated channel subunit alpha1 E / Q15878*ENSMUSG0000000411036
Nalcn / sodium leak channel, non-selective / Q8IZF0*ENSMUSG0000000019717
Q91ZR5 / Catsper1 / Cation channel sperm-associated protein 1 / Q8NEC5* / cation channel sperm associated 1*ENSMUSG000000384986


Protein motifs (from Interpro)
Interpro ID Name
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005446  Voltage-dependent calcium channel, L-type, alpha-1 subunit
 IPR005451  Voltage-dependent calcium channel, L-type, alpha-1C subunit
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain
 IPR031688  Voltage-gated calcium channel subunit alpha, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002520 immune system development ISO
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006939 smooth muscle contraction IMP
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007507 heart development ISO
 biological_processGO:0007628 adult walking behavior IGI
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0017156 calcium ion regulated exocytosis IMP
 biological_processGO:0019229 regulation of vasoconstriction IMP
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0030252 growth hormone secretion IDA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis ISO
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043010 camera-type eye development ISO
 biological_processGO:0046620 regulation of organ growth IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060083 smooth muscle contraction involved in micturition IMP
 biological_processGO:0061337 cardiac conduction ISS
 biological_processGO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel ISO
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086002 cardiac muscle cell action potential involved in contraction ISS
 biological_processGO:0086010 membrane depolarization during action potential IBA
 biological_processGO:0086012 membrane depolarization during cardiac muscle cell action potential ISO
 biological_processGO:0086045 membrane depolarization during AV node cell action potential ISO
 biological_processGO:0086091 regulation of heart rate by cardiac conduction ISS
 biological_processGO:0098911 regulation of ventricular cardiac muscle cell action potential ISS
 biological_processGO:0098912 membrane depolarization during atrial cardiac muscle cell action potential ISO
 cellular_componentGO:0002095 caveolar macromolecular signaling complex IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0014069 postsynaptic density ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030315 T-tubule TAS
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043198 dendritic shaft IDA
 cellular_componentGO:0045211 postsynaptic membrane ISS
 cellular_componentGO:1990454 L-type voltage-gated calcium channel complex ISO
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IBA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051393 alpha-actinin binding ISS
 molecular_functionGO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential ISO
 molecular_functionGO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential ISO
 molecular_functionGO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential IMP


Pathways (from Reactome)
Pathway description
Regulation of insulin secretion
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Cacna1ctm2Itl/Cacna1c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MccGt(W197F04)Wrst/MccGt(W197F04)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cacng4tm1Dgen/Cacng4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacng4tm1Dgen/Cacng4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: MccGt(W197F04)Wrst/MccGt(W197F04)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Cacna1ctm2Itl/Cacna1c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: MccGt(W197F04)Wrst/MccGt(W197F04)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Cacna1ctm1.1Wac/Cacna1ctm1.1Wac
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Trp53tm2Tyj/Trp53tm2Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mybtm1Cgn/Mybtm1Cgn,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cacna1ctm1Ggm/Cacna1ctm1Ggm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cacna1ctm2Itl/Cacna1c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Cacna1ctm2Itl/Cacna1c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mybtm1Cgn/Mybtm1Cgn,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Mybtm1Cgn/Mybtm1Cgn,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Cacng4tm1Dgen/Cacng4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1ctm1.1Wac/Cacna1ctm1.1Wac
Genetic Background: involves: C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003061 decreased aerobic running capacity "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: Cacna1ctm1.1Wac/Cacna1ctm1.1Wac
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Mybtm1Cgn/Mybtm1Cgn,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004145 abnormal muscle electrophysiology "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cacna1ctm1.1Wac/Cacna1ctm1.1Wac
Genetic Background: involves: C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybtm1Cgn/Mybtm1Cgn,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

Allelic Composition: Cacna1ctm5.1Hfm/Cacna1ctm5.1Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cacna1ctm1.1Wac/Cacna1ctm1.1Wac
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

Allelic Composition: Cacna1ctm1.1Wac/Cacna1ctm1.1Wac
Genetic Background: involves: C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1ctm1Ggm/Cacna1ctm1Ggm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Cacna1ctm1.1Wac/Cacna1ctm1.1Wac
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Trp53tm2Tyj/Trp53tm2Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ctm1Ggm/Cacna1ctm1Ggm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ctm2Itl/Cacna1c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MccGt(W197F04)Wrst/MccGt(W197F04)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009455 enhanced cued conditioning behavior "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MccGt(W197F04)Wrst/MccGt(W197F04)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cacna1ctm5.1Hfm/Cacna1ctm5.1Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cacna1ctm2Itl/Cacna1c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Cacna1ctm2Itl/Cacna1ctm2Itl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cacng4tm1Dgen/Cacng4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

 MP:0011390 abnormal fetal cardiomyocyte physiology "any functional anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [MGI:csmith, PMID:17429040]
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Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0012557 decreased calcium uptake by cardiac muscle "decreased directed movement of calcium ions into cardiac muscle; decreased or disrupted uptake may give rise to energetic deficit and oxidative stress. leading to cardiac disease" [http://orcid.org/0000-0001-5208-3432, PMID:22902320]
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Allelic Composition: Cacna1ctm2.1Wac/Cacna1ctm2.1Wac
Genetic Background: involves: C57BL/6

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Cacna1ctm2Itl/Cacna1c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010066 Q6PHS9 / Cacna2d2 / Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 / Q9NY47*...  / complex
 ENSMUSG00000003352 Cacnb3 / P54285 / Mus musculus calcium channel, voltage-dependent, beta 3 subunit (Cacnb3), transcript variant 4, mRNA. / P54284* / calcium voltage-gated channel auxiliary subunit beta 3*  / complex
 ENSMUSG00000020882 Cacnb1 / Q8R3Z5 / Voltage-dependent L-type calcium channel subunit beta-1 / Q02641* / calcium voltage-gated channel auxiliary subunit beta 1*  / complex
 ENSMUSG00000041460 Cacna2d4 / voltage-dependent calcium channel subunit alpha-2/delta-4 isoform 2 / Q7Z3S7* / calcium voltage-gated channel auxiliary subunit alpha2delta 4*  / complex
 ENSMUSG00000017412 Cacnb4 / Q8R0S4 / Mus musculus calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), transcript variant 6, mRNA. / O00305* / AC068547.1* / calcium voltage-gated channel auxiliary sub...  / complex
 ENSMUSG00000051331 Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*  / complex
 ENSMUSG00000057914 Cacnb2 / Q8CC27 / Voltage-dependent L-type calcium channel subunit beta-2 / Q08289* / calcium voltage-gated channel auxiliary subunit beta 2*  / complex






 

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