ENSDARG00000008398


Danio rerio

Features
Gene ID: ENSDARG00000008398
  
Biological name :cacna1c
  
Synonyms : cacna1c / calcium channel, voltage-dependent, L type, alpha 1C subunit
  
Possible biological names infered from orthology : calcium voltage-gated channel subunit alpha1 C / Q01815 / Q13936 / Voltage-dependent L-type calcium channel subunit alpha-1C
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 20318127
Gene end: 20474972
  
Corresponding Affymetrix probe sets: Dr.12606.1.S1_at (Zebrafish Array)   NM_131900_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000031067
Ensembl peptide - ENSDARP00000116425
NCBI entrez gene - 170581     See in Manteia.
RefSeq - NM_131900
RefSeq Peptide - NP_571975
swissprot - F1R1T3
swissprot - Q5TZF1
ZFIN ID - ZDB-GENE-020129-1
Ensembl - ENSDARG00000008398
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CACNA1CENSGALG00000013022Gallus gallus
 Q13936ENSG00000151067Homo sapiens
 Q01815ENSMUSG00000051331Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cacna1da / calcium channel, voltage-dependent, L type, alpha 1D subunit, a / Q01668* / CACNA1D* / calcium voltage-gated channel subunit alpha1 D*ENSDARG0000010277362
cacna1fb / calcium channel, voltage-dependent, L type, alpha 1F subunit / O60840* / CACNA1F* / calcium voltage-gated channel subunit alpha1 F*ENSDARG0000002368354
cacna1sa / calcium channel, voltage-dependent, L type, alpha 1S subunit, a / Q13698* / CACNA1S* / calcium voltage-gated channel subunit alpha1 S*ENSDARG0000002945752
cacna1sb / calcium channel, voltage-dependent, L type, alpha 1S subunit, b / Q13698* / CACNA1S* / calcium voltage-gated channel subunit alpha1 S*ENSDARG0000004255250
cacna1ab / calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b / O00555* / P97445* / CACNA1A* / calcium voltage-gated channel subunit alpha1 A* / Voltage-dependent P/Q-type ca...ENSDARG0000000692337
cacna1ba / calcium channel, voltage-dependent, N type, alpha 1B subunit, a / O55017* / Q00975* / CACNA1B* / calcium voltage-gated channel subunit alpha1 B* / Voltage-dependent N-type calciu...ENSDARG0000002173536
cacna1aa / calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a / O00555* / CACNA1A* / calcium voltage-gated channel subunit alpha1 A*ENSDARG0000003790536
cacna1bb / calcium channel, voltage-dependent, N type, alpha 1B subunit, b / O55017* / Q00975* / CACNA1B* / calcium voltage-gated channel subunit alpha1 B* / Voltage-dependent N-type calciu...ENSDARG0000007929536
cacna1eb / calcium channel, voltage-dependent, R type, alpha 1E subunit b / Q15878* / CACNA1E* / calcium voltage-gated channel subunit alpha1 E*ENSDARG0000009561434
cacna1ea / calcium channel, voltage-dependent, R type, alpha 1E subunit a / Q15878* / CACNA1E* / calcium voltage-gated channel subunit alpha1 E*ENSDARG0000006234626
cacna1fa / calcium channel, voltage-dependent, L type, alpha 1F subunit a / O60840* / CACNA1F* / calcium voltage-gated channel subunit alpha1 F*ENSDARG0000001093320
nalcn / sodium leak channel, non-selective / Q8IZF0*ENSDARG0000000183517
cacna1db / calcium channel, voltage-dependent, L type, alpha 1D subunit, b / Q01668* / CACNA1D* / calcium voltage-gated channel subunit alpha1 D*ENSDARG0000011064216
FO082780.1 / O60840* / CACNA1F* / calcium voltage-gated channel subunit alpha1 F*ENSDARG000001155289
cacna1db / calcium channel, voltage-dependent, L type, alpha 1D subunit, b / Q01668* / CACNA1D* / calcium voltage-gated channel subunit alpha1 D*ENSDARG000001156038


Protein motifs (from Interpro)
Interpro ID Name
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005446  Voltage-dependent calcium channel, L-type, alpha-1 subunit
 IPR005451  Voltage-dependent calcium channel, L-type, alpha-1C subunit
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain
 IPR031688  Voltage-gated calcium channel subunit alpha, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003301 physiological cardiac muscle hypertrophy IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070509 calcium ion import IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IMP
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IBA


Pathways (from Reactome)
Pathway description
Regulation of insulin secretion
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
brain hydrocephalic , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle non-functional , abnormal
cardiac ventricle morphology , abnormal
cardiac ventricle cardiac muscle cell non-contractile , abnormal
cardiac ventricle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk edematous , abnormal
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 ZFA:0000114 heart heart quality , abnormal
heart contractility , abnormal
heart decreased contractility , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct dilated , abnormal
pronephric duct cystic , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage chondrocyte decreased size , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch decreased size , abnormal
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 ZFA:0001374 atrial myocardium atrial myocardium contractility , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus unfused from pronephric glomerulus , abnormal
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 ZFA:0001673 pronephric podocyte pronephric podocyte unfused from pronephric podocyte , abnormal
Show

 ZFA:0005061 ventricular myocardium ventricular myocardium decreased thickness , abnormal
ventricular myocardium non-functional , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased volume , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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