ENSMUSG00000004885


Mus musculus

Features
Gene ID: ENSMUSG00000004885
  
Biological name :Crabp2
  
Synonyms : Cellular retinoic acid-binding protein 2 / Crabp2 / P22935
  
Possible biological names infered from orthology : P29373
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 87948666
Gene end: 87953376
  
Corresponding Affymetrix probe sets: 10493108 (MoGene1.0st)   1451191_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005019
NCBI entrez gene - 12904     See in Manteia.
MGI - MGI:88491
RefSeq - NM_007759
RefSeq Peptide - NP_031785
swissprot - P22935
Ensembl - ENSMUSG00000004885
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crabp2aENSDARG00000073978Danio rerio
 crabp2bENSDARG00000030449Danio rerio
 CRABP2ENSGALG00000029140Gallus gallus
 CRABP2ENSG00000143320Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crabp1 / P62965 / Cellular retinoic acid-binding protein 1 / P29762*ENSMUSG0000003229172
Fabp3 / P11404 / Fatty acid-binding protein, heart / P05413* / fatty acid binding protein 3*ENSMUSG0000002877342
Rbp1 / Q00915 / retinol binding protein 1, cellular / P09455* / retinol binding protein 1*ENSMUSG0000004640241
Fabp9 / O08716 / Fatty acid-binding protein 9 / Q0Z7S8*ENSMUSG0000002752840
Rbp7 / Q9EPC5 / retinol binding protein 7, cellular / Q96R05* / retinol binding protein 7*ENSMUSG0000002899639
Fabp7 / P51880 / Fatty acid-binding protein, brain / O15540* / fatty acid binding protein 7*ENSMUSG0000001987438
Pmp2 / P24526 / peripheral myelin protein 2 / P02689*ENSMUSG0000005246838
Fabp12 / Q9DAK4 / Fatty acid-binding protein 12 / A6NFH5*ENSMUSG0000002753036
Rbp2 / Q08652 / retinol binding protein 2, cellular / P50120* / retinol binding protein 2*ENSMUSG0000003245436
Fabp4 / P04117 / Fatty acid-binding protein, adipocyte / P15090* / fatty acid binding protein 4*ENSMUSG0000006251534
Fabp5 / Q05816 / Fatty acid-binding protein, epidermal / Q01469* / fatty acid binding protein 5*ENSMUSG0000002753332
Gm37389 / FABP9* / Q0Z7S8* / fatty acid binding protein 9*ENSMUSG0000010312428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000463  Cytosolic fatty-acid binding
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR012674  Calycin
 IPR031259  Intracellular lipid binding protein
 IPR031281  Cellular retinoic acid-binding protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035115 embryonic forelimb morphogenesis IMP
 biological_processGO:0042573 retinoic acid metabolic process IDA
 biological_processGO:0048385 regulation of retinoic acid receptor signaling pathway IEA
 biological_processGO:0048672 positive regulation of collateral sprouting IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0001972 retinoic acid binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016918 retinal binding IEA
 molecular_functionGO:0019841 retinol binding IEA
 molecular_functionGO:0030332 cyclin binding ISO


Pathways (from Reactome)
Pathway description
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

Allelic Composition: Crabp2tm1Ipc/Crabp2tm1Ipc
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0009744 postaxial polydactyly "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015843 Rxrg / P28705 / Retinoic acid receptor RXR-gamma / P48443* / retinoid X receptor gamma*  / complex / reaction
 ENSMUSG00000001288 Rarg / P18911 / Retinoic acid receptor gamma / P13631*  / complex / reaction
 ENSMUSG00000017491 Rarb / P22605 / retinoic acid receptor, beta / P10826*  / complex / reaction
 ENSMUSG00000037992 Rara / P11416 / retinoic acid receptor, alpha / P10276*  / complex / reaction
 ENSMUSG00000039656 Rxrb / P28704 / retinoid X receptor beta / P28702*  / complex / reaction
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / complex / reaction






 

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