ENSMUSG00000005864


Mus musculus

Features
Gene ID: ENSMUSG00000005864
  
Biological name :Cnga2
  
Synonyms : Cnga2 / Cyclic nucleotide-gated olfactory channel / Q62398
  
Possible biological names infered from orthology : cyclic nucleotide gated channel alpha 2 / Q16280
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 71991849
Gene end: 72010218
  
Corresponding Affymetrix probe sets: 10600057 (MoGene1.0st)   1422181_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006020
NCBI entrez gene - 12789     See in Manteia.
MGI - MGI:108040
RefSeq - XM_006527761
RefSeq - NM_007724
RefSeq Peptide - NP_031750
swissprot - Q62398
swissprot - A3KGE1
Ensembl - ENSMUSG00000005864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnga2ENSDARG00000100436Danio rerio
 cnga5ENSDARG00000102968Danio rerio
 CNGA2ENSGALG00000007282Gallus gallus
 CNGA2ENSG00000183862Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnga3 / Q9JJZ8 / Cyclic nucleotide-gated cation channel alpha-3 / Q16281* / cyclic nucleotide gated channel alpha 3*ENSMUSG0000002611464
Cnga1 / P29974 / cGMP-gated cation channel alpha-1 / P29973* / cyclic nucleotide gated channel alpha 1*ENSMUSG0000006722059
Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*ENSMUSG0000003089743
Cngb1 / cyclic nucleotide gated channel beta 1 / Q14028*ENSMUSG0000003178928
Cngb3 / Q9JJZ9 / Cyclic nucleotide-gated cation channel beta-3 / Q9NQW8* / cyclic nucleotide gated channel beta 3*ENSMUSG0000005649425
Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / O60741* / hyperpolarization activated cyclic nucleotide gated potassium channel 1*ENSMUSG0000002173022
Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*ENSMUSG0000003233822
Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / Q9UL51* / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2*ENSMUSG0000002033120
Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 / Q9P1Z3* / hyperpolarization activated cyclic nucleotide gated potassium channel 3*ENSMUSG0000002805120


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR032406  Cyclic nucleotide-gated channel, C-terminal leucine zipper domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007608 sensory perception of smell IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IMP
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0030552 cAMP binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom,Olfr160tm4Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Y,Olfr160tm4Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * 129S1/SvImJ * C57BL/6J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnga2tm1Mom/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctsgtm2(PML/RARA)Ley/Ctsgtm2(PML/RARA)Ley
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cnga2tm1Ngai/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cnga2tm1Reed/Y
Genetic Background: involves: 129/Sv * BALB/cJ

Allelic Composition: Cnga2tm1Mom/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom,Olfr160tm5(Cnga2)Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Y,Olfr160tm5(Cnga2)Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm2Reed/Y
Genetic Background: involves: 129/Sv * BALB/cJ

 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctsgtm2(PML/RARA)Ley/Ctsgtm2(PML/RARA)Ley
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * 129S1/SvImJ * C57BL/6J

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0004512 anosmia "loss of the sense of smell" [mberry:Melissa Berry_Genetic Resources Curator]
Show

Allelic Composition: Cnga2tm1Ngai/Y
Genetic Background: involves: 129S1/Sv

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Cnga2tm1Mom/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom,Olfr160tm5(Cnga2)Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Y,Olfr160tm5(Cnga2)Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005236 abnormal olfactory nerve morphology "anomalous structure of the first cranial nerve, which conveys the sense of smell" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * 129S1/SvImJ * C57BL/6J

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
Show

Allelic Composition: Cnga2tm1Reed/Y
Genetic Background: involves: 129/Sv * BALB/cJ

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom,Olfr160tm4Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Y,Olfr160tm4Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010055 abnormal sensory neuron physiology "any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cnga2tm1Reed/Y
Genetic Background: involves: 129/Sv * BALB/cJ

Allelic Composition: Cnga2tm2Reed/Y
Genetic Background: involves: 129/Sv * BALB/cJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cnga2tm1Ngai/Y
Genetic Background: involves: 129S1/Sv

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cnga2tm1Mom/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * 129S1/SvImJ * C57BL/6J

 MP:0011677 abnormal olfactory sensory neuron physiology "any functional anomaly of cells that innervate the olfactory epithelium and are responsible for receiving and transmitting odorant signals" [MGI:csmith]
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Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom,Trpc2tm2Mom/Trpc2tm2Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cnga2tm1Mom/Y,Trpc2tm2Mom/Trpc2tm2Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012014 abnormal olfactory neuron innervation pattern "any changes in the placement, morphology or number of axons from olfactory neurons to an effector tissue or to olfactory glomeruli or olfactory bulb" [MGI:csmith]
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Allelic Composition: Cnga2tm1Mom/Cnga2tm1Mom,Olfr151tm2Mom/Olfr151tm4Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / complex
 ENSMUSG00000004771 P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*  / complex / reaction
 ENSMUSG00000005864 Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*  / complex
 ENSMUSG00000022377 Asap1 / Q9QWY8 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Q9ULH1* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1*  / complex
 ENSMUSG00000021877 Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*  / complex / reaction
 ENSMUSG00000037098 Q8CHD8 / Rab11fip3 / Rab11 family-interacting protein 3 / O75154*  / complex / reaction
 ENSMUSG00000030897 Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*  / complex






 

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