ENSMUSG00000020331


Mus musculus

Features
Gene ID: ENSMUSG00000020331
  
Biological name :Hcn2
  
Synonyms : Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
  
Possible biological names infered from orthology : hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 / Q9UL51
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79716634
Gene end: 79736108
  
Corresponding Affymetrix probe sets: 10364478 (MoGene1.0st)   1421154_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020581
Ensembl peptide - ENSMUSP00000097113
NCBI entrez gene - 15166     See in Manteia.
MGI - MGI:1298210
RefSeq - NM_008226
RefSeq Peptide - NP_032252
swissprot - O88703
Ensembl - ENSMUSG00000020331
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HCN2ENSGALG00000001342Gallus gallus
 HCN2ENSG00000099822Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*ENSMUSG0000003233868
Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / O60741* / hyperpolarization activated cyclic nucleotide gated potassium channel 1*ENSMUSG0000002173060
Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 / Q9P1Z3* / hyperpolarization activated cyclic nucleotide gated potassium channel 3*ENSMUSG0000002805155
Cngb1 / cyclic nucleotide gated channel beta 1 / Q14028*ENSMUSG0000003178918
Cnga3 / Q9JJZ8 / Cyclic nucleotide-gated cation channel alpha-3 / Q16281* / cyclic nucleotide gated channel alpha 3*ENSMUSG0000002611417
Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*ENSMUSG0000000586416
Cnga1 / P29974 / cGMP-gated cation channel alpha-1 / P29973* / cyclic nucleotide gated channel alpha 1*ENSMUSG0000006722016
Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*ENSMUSG0000003089714
Cngb3 / Q9JJZ9 / Cyclic nucleotide-gated cation channel beta-3 / Q9NQW8* / cyclic nucleotide gated channel beta 3*ENSMUSG0000005649414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR005821  Ion transport domain
 IPR013621  Ion transport N-terminal
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport ISO
 biological_processGO:0042391 regulation of membrane potential ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071320 cellular response to cAMP ISS
 biological_processGO:0071321 cellular response to cGMP ISO
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 biological_processGO:0098719 sodium ion import across plasma membrane ISO
 biological_processGO:1990573 potassium ion import across plasma membrane ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098855 HCN channel complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005222 intracellular cAMP activated cation channel activity ISO
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity ISO
 molecular_functionGO:0005249 voltage-gated potassium channel activity ISS
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
HCN channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

Allelic Composition: Hcn2tm1Ldw/Hcn2tm1Ldw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hcn2trls-2J/Hcn2trls-2J
Genetic Background: B6.WB-Hcn2trls-2J/J

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ryr3tm1Tno/Ryr3+
Genetic Background: involves: 129S4/SvJae * C57BL/6N

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

Allelic Composition: Hcn2m1Btlr/Hcn2m1Btlr
Genetic Background: C57BL/6J-Hcn2m1Btlr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

Allelic Composition: Hcn2trls-2J/Hcn2trls-2J
Genetic Background: B6.WB-Hcn2trls-2J/J

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: involves: C57BL/6J * DW/Pas

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

Allelic Composition: Hcn2tm1.2Lex/Hcn2tm1.2Lex
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Hcn2m1Btlr/Hcn2m1Btlr
Genetic Background: C57BL/6J-Hcn2m1Btlr

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Hcn2tm1Ldw/Hcn2tm1Ldw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: involves: C57BL/6J * DW/Pas

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: involves: C57BL/6J * DW/Pas

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: involves: C57BL/6J * DW/Pas

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Ryr3tm1Tno/Ryr3+
Genetic Background: involves: 129S4/SvJae * C57BL/6N

Allelic Composition: Hcn2tm1Ldw/Hcn2tm2Ldw,Myl7tm1(cre)Krc/Myl7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: involves: C57BL/6J * DW/Pas

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fat3tm1.2Good/Fat3+,Fjx1tm1Awp/Fjx1tm1Awp
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Hcn2tm1.1Lex/Hcn2tm1.1Lex,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: involves: C57BL/6J * DW/Pas

Allelic Composition: Hcn2tm1.2Lex/Hcn2tm1.2Lex
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hcn2tm1Ldw/Hcn2tm1Ldw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcn2tm1.1Lex/Hcn2tm1.1Lex,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hcn2tm1Ldw/Hcn2tm1Ldw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

Allelic Composition: Hcn2ap/Hcn2+
Genetic Background: DW/Pas-Hcn2ap

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

 MP:0003360 depression-related behavior 
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: involves: C57BL/6J * DW/Pas

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
Show

Allelic Composition: Hcn2tm1Ldw/Hcn2tm1Ldw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003470 abnormal summary potential "anomaly in the electrophysiological recording of the activity of several cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Hcn2tm1Ldw/Hcn2tm1Ldw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003488 decreased channel response intensity 
Show

Allelic Composition: Hcn2tm1Ldw/Hcn2tm1Ldw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Hcn2tm1.2Lex/Hcn2tm1.2Lex
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcn2tm1.2Lex/Hcn2tm1.2Lex
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcn2tm1Ldw/Hcn2tm1Ldw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hcn2tm1Ldw/Hcn2tm2Ldw,Myl7tm1(cre)Krc/Myl7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn2m1Btlr/Hcn2m1Btlr
Genetic Background: C57BL/6J-Hcn2m1Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn2m1Btlr/Hcn2m1Btlr
Genetic Background: C57BL/6J-Hcn2m1Btlr

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn2tm1.1Lex/Hcn2tm1.1Lex,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: DW/Pas-Hcn2ap

Allelic Composition: Hcn2ap/Hcn2+
Genetic Background: DW/Pas-Hcn2ap

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
Show

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hcn2trls-2J/Hcn2trls-2J
Genetic Background: B6.WB-Hcn2trls-2J/J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Hcn2ap/Hcn2ap
Genetic Background: involves: C57BL/6J * DW/Pas

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020331 Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / Q9UL51* / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr