ENSMUSG00000006576


Mus musculus

Features
Gene ID: ENSMUSG00000006576
  
Biological name :Slc4a3
  
Synonyms : P16283 / Slc4a3 / solute carrier family 4 (anion exchanger), member 3
  
Possible biological names infered from orthology : P48751 / solute carrier family 4 member 3
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 75546266
Gene end: 75562172
  
Corresponding Affymetrix probe sets: 10347697 (MoGene1.0st)   10347724 (MoGene1.0st)   1418485_at (Mouse Genome 430 2.0 Array)   1453687_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119942
Ensembl peptide - ENSMUSP00000119860
Ensembl peptide - ENSMUSP00000120078
Ensembl peptide - ENSMUSP00000122749
Ensembl peptide - ENSMUSP00000027415
Ensembl peptide - ENSMUSP00000116488
Ensembl peptide - ENSMUSP00000116747
NCBI entrez gene - 20536     See in Manteia.
MGI - MGI:109350
RefSeq - XM_011238679
RefSeq - XM_006496449
RefSeq - XM_006496450
RefSeq - XM_006496451
RefSeq - XM_006496452
RefSeq - XM_006496453
RefSeq - XM_006496454
RefSeq - XM_006496455
RefSeq - XM_006496456
RefSeq - XM_006496457
RefSeq - XM_006496458
RefSeq - NM_009208
RefSeq Peptide - NP_001344079
RefSeq Peptide - NP_033234
RefSeq Peptide - NP_001344078
swissprot - F8WHM3
swissprot - D3Z3U9
swissprot - D3YWK8
swissprot - D3Z5A2
swissprot - P16283
swissprot - F6Q7T0
swissprot - F6S265
Ensembl - ENSMUSG00000006576
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc4a3ENSDARG00000104005Danio rerio
 SLC4A3ENSGALG00000011224Gallus gallus
 P48751ENSG00000114923Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc4a2 / solute carrier family 4 (anion exchanger), member 2 / P04920* / solute carrier family 4 member 2*ENSMUSG0000002896258
P04919 / Slc4a1 / solute carrier family 4 (anion exchanger), member 1 / P02730* / solute carrier family 4 member 1 (Diego blood group)*ENSMUSG0000000657440
Slc4a7 / solute carrier family 4, sodium bicarbonate cotransporter, member 7 / Q9Y6M7* / solute carrier family 4 member 7*ENSMUSG0000002173333
Q5DTL9 / Slc4a10 / solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 / Q6U841* / solute carrier family 4 member 10*ENSMUSG0000002690432
O88343 / Slc4a4 / solute carrier family 4 (anion exchanger), member 4 / Q9Y6R1* / solute carrier family 4 member 4*ENSMUSG0000006096132
Q8JZR6 / Slc4a8 / solute carrier family 4 (anion exchanger), member 8 / Q2Y0W8* / solute carrier family 4 member 8*ENSMUSG0000002303231
Slc4a5 / solute carrier family 4 member 5 / Q9BY07*ENSMUSG0000006832329
Slc4a9 / anion exchange protein 4 isoform 5 / Q96Q91* / solute carrier family 4 member 9*ENSMUSG0000002448527
A2AJN7 / Slc4a11 / Sodium bicarbonate transporter-like protein 11 / Q8NBS3* / solute carrier family 4 member 11*ENSMUSG0000007479618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001717  Anion exchange protein
 IPR002979  Anion exchange protein 3
 IPR003020  Bicarbonate transporter, eukaryotic
 IPR011531  Bicarbonate transporter, C-terminal
 IPR013769  Band 3 cytoplasmic domain
 IPR016152  Phosphotransferase/anion transporter
 IPR018241  Anion exchange, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0015701 bicarbonate transport IEA
 biological_processGO:0051453 regulation of intracellular pH IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005452 inorganic anion exchanger activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0008510 sodium:bicarbonate symporter activity IBA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IDA


Pathways (from Reactome)
Pathway description
Bicarbonate transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Limm/Bdnftm1Limm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bdnftm1Limm/Bdnftm1Limm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Limm/Bdnftm1Limm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: FVB/N

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Limm/Bdnftm1Limm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: FVB/N

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Hoxa9tm1Mrc/Hoxa9+,Hoxb9tm1Mrc/Hoxb9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004043 abnormal pH regulation "anomaly in the function of the buffer systems of the body in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the body, as measured by the concentration of hydrogen ion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa9tm1Mrc/Hoxa9+,Hoxb9tm1Mrc/Hoxb9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Bdnftm1Limm/Bdnftm1Limm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: FVB/N

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Bdnftm1Limm/Bdnftm1Limm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Bdnftm1Limm/Bdnftm1Limm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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