ENSMUSG00000068323


Mus musculus

Features
Gene ID: ENSMUSG00000068323
  
Biological name :Slc4a5
  
Synonyms : Slc4a5 / solute carrier family 4 member 5
  
Possible biological names infered from orthology : Q9BY07
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 83219828
Gene end: 83304945
  
Corresponding Affymetrix probe sets: 10539393 (MoGene1.0st)   1435420_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041007
Ensembl peptide - ENSMUSP00000109533
Ensembl peptide - ENSMUSP00000109532
NCBI entrez gene - 232156     See in Manteia.
MGI - MGI:2443220
RefSeq - XM_006505967
RefSeq - XM_006505963
RefSeq - XM_006505964
RefSeq - XM_006505965
RefSeq - XM_006505966
RefSeq - NM_001166067
RefSeq Peptide - NP_001159539
swissprot - D3YX36
swissprot - D3YVG0
swissprot - E9Q3M5
Ensembl - ENSMUSG00000068323
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-48m9.1ENSDARG00000002771Danio rerio
 slc4a5ENSDARG00000104387Danio rerio
 SLC4A5ENSGALG00000032146Gallus gallus
 Q9BY07ENSG00000188687Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O88343 / Slc4a4 / solute carrier family 4 (anion exchanger), member 4 / Q9Y6R1* / solute carrier family 4 member 4*ENSMUSG0000006096163
Slc4a7 / solute carrier family 4, sodium bicarbonate cotransporter, member 7 / Q9Y6M7* / solute carrier family 4 member 7*ENSMUSG0000002173349
Q8JZR6 / Slc4a8 / solute carrier family 4 (anion exchanger), member 8 / Q2Y0W8* / solute carrier family 4 member 8*ENSMUSG0000002303249
Q5DTL9 / Slc4a10 / solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 / Q6U841* / solute carrier family 4 member 10*ENSMUSG0000002690449
Slc4a9 / anion exchange protein 4 isoform 5 / Q96Q91* / solute carrier family 4 member 9*ENSMUSG0000002448542
P16283 / Slc4a3 / solute carrier family 4 (anion exchanger), member 3 / P48751* / solute carrier family 4 member 3*ENSMUSG0000000657636
Slc4a2 / solute carrier family 4 (anion exchanger), member 2 / P04920* / solute carrier family 4 member 2*ENSMUSG0000002896235
P04919 / Slc4a1 / solute carrier family 4 (anion exchanger), member 1 / P02730* / solute carrier family 4 member 1 (Diego blood group)*ENSMUSG0000000657431
A2AJN7 / Slc4a11 / Sodium bicarbonate transporter-like protein 11 / Q8NBS3* / solute carrier family 4 member 11*ENSMUSG0000007479620


Protein motifs (from Interpro)
Interpro ID Name
 IPR003020  Bicarbonate transporter, eukaryotic
 IPR003024  Sodium bicarbonate cotransporter
 IPR011531  Bicarbonate transporter, C-terminal
 IPR013769  Band 3 cytoplasmic domain
 IPR016152  Phosphotransferase/anion transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002064 epithelial cell development IMP
 biological_processGO:0003014 renal system process IMP
 biological_processGO:0003073 regulation of systemic arterial blood pressure IMP
 biological_processGO:0006811 ion transport IMP
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0015701 bicarbonate transport IEA
 biological_processGO:0033326 cerebrospinal fluid secretion IMP
 biological_processGO:0048311 mitochondrion distribution IMP
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0098656 anion transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005452 inorganic anion exchanger activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0008510 sodium:bicarbonate symporter activity IBA


Pathways (from Reactome)
Pathway description
Bicarbonate transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0003353 decreased circulating renin level "reduced blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0005522 increased circulating atrial natriuretic factor "greater than the normal concentration of this peptide hormone in the blood; it regulates the water-electrolyte balance and acts as a vasodilator" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0005527 increased glomerular filtration rate "greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

 MP:0011462 increased urine bicarbonate level "an increased amount of bicarbonate in the urine compared to the normal state" [MGI:csmith]
Show

Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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