ENSMUSG00000010047


Mus musculus

Features
Gene ID: ENSMUSG00000010047
  
Biological name :Hyal2
  
Synonyms : Hyal2 / Hyaluronidase-2 / O35632
  
Possible biological names infered from orthology : hyaluronoglucosaminidase 2 / Q12891
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 107567945
Gene end: 107572779
  
Corresponding Affymetrix probe sets: 10588683 (MoGene1.0st)   1448679_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141820
Ensembl peptide - ENSMUSP00000142207
Ensembl peptide - ENSMUSP00000142141
Ensembl peptide - ENSMUSP00000142019
Ensembl peptide - ENSMUSP00000010191
Ensembl peptide - ENSMUSP00000141280
NCBI entrez gene - 15587     See in Manteia.
MGI - MGI:1196334
RefSeq - NM_010489
RefSeq - XM_006511643
RefSeq - XM_006511644
RefSeq - XM_006511645
RefSeq Peptide - NP_034619
swissprot - O35632
swissprot - A0A0A6YXJ6
swissprot - A0A0A6YX37
swissprot - A0A0A6YXZ3
swissprot - Q3UZE4
swissprot - Q8C309
Ensembl - ENSMUSG00000010047
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hyal2aENSDARG00000059931Danio rerio
 hyal2bENSDARG00000062997Danio rerio
 HYAL2ENSGALG00000002138Gallus gallus
 HYAL2ENSG00000068001Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hyal6 / hyaluronoglucosaminidase 6ENSMUSG0000002967939
Hyal5 / Q812F3 / Hyaluronidase-5 / SPAM1* / P38567* / sperm adhesion molecule 1*ENSMUSG0000002967838
Spam1 / P48794 / sperm adhesion molecule 1 / P38567*ENSMUSG0000002968238
Hyal1 / Q91ZJ9 / Mus musculus hyaluronoglucosaminidase 1 (Hyal1), transcript variant 2, mRNA. / Q12794* / hyaluronoglucosaminidase 1*ENSMUSG0000001005137
Hyal4 / Q05A56 / Hyaluronidase-4 / Q2M3T9* / hyaluronoglucosaminidase 4*ENSMUSG0000002968037
Hyal3 / Q8VEI3 / Hyaluronidase-3 / O43820* / hyaluronoglucosaminidase 3*ENSMUSG0000003609135


Protein motifs (from Interpro)
Interpro ID Name
 IPR013785  Aldolase-type TIM barrel
 IPR017853  Glycoside hydrolase superfamily
 IPR018155  Hyaluronidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species ISO
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006027 glycosaminoglycan catabolic process ISS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0010259 multicellular organism aging IMP
 biological_processGO:0010764 negative regulation of fibroblast migration ISO
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane ISO
 biological_processGO:0019087 transformation of host cell by virus ISO
 biological_processGO:0030214 hyaluronan catabolic process ISO
 biological_processGO:0030308 negative regulation of cell growth ISS
 biological_processGO:0035810 positive regulation of urine volume ISS
 biological_processGO:0042117 monocyte activation ISS
 biological_processGO:0042307 positive regulation of protein import into nucleus IDA
 biological_processGO:0043407 negative regulation of MAP kinase activity ISO
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0046718 viral entry into host cell ISS
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0050729 positive regulation of inflammatory response ISO
 biological_processGO:0051216 cartilage development ISS
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0051898 negative regulation of protein kinase B signaling ISS
 biological_processGO:0060586 multicellular organismal iron ion homeostasis IMP
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity ISO
 biological_processGO:0070295 renal water absorption ISS
 biological_processGO:0071347 cellular response to interleukin-1 ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071493 cellular response to UV-B ISO
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion ISS
 biological_processGO:2000778 positive regulation of interleukin-6 secretion ISO
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0000139 Golgi membrane ISS
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0030139 endocytic vesicle ISS
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0046658 anchored component of plasma membrane ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0001618 virus receptor activity IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004415 hyalurononglucosaminidase activity ISS
 molecular_functionGO:0005540 hyaluronic acid binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030294 receptor signaling protein tyrosine kinase inhibitor activity ISO
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISO
 molecular_functionGO:0033906 hyaluronoglucuronidase activity ISO
 molecular_functionGO:0050431 transforming growth factor beta binding IPI


Pathways (from Reactome)
Pathway description
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0010030 abnormal orbit morphology "any structural anomaly of the bony ring that supports the eyeball and supporting tissues and is formed by parts of several cranial bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0010701 fusion of atlas and odontoid process "the large protuberance that projects upward from the cervical axis (C2), around which the cervical atlas normally rotates, is instead fused to elements of the atlas; the odontoid process may or may not remain attached to the axis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(KRT5-cre)5132Jlj/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014077 Chp1 / P61022 / Calcineurin B homologous protein 1 / Q99653* / calcineurin like EF-hand protein 1*  / complex / reaction
 ENSMUSG00000028854 Q61165 / Slc9a1 / solute carrier family 9 (sodium/hydrogen exchanger), member 1 / P19634* / solute carrier family 9 member A1*  / complex / reaction
 ENSMUSG00000020330 Hmmr / Q00547 / Hyaluronan mediated motility receptor / O75330*  / complex / reaction
 ENSMUSG00000035459 Stab2 / Q8R4U0 / Stabilin-2 Short form stabilin-2 / Q8WWQ8* / stabilin 2*  / complex / reaction
 ENSMUSG00000030787 Lyve1 / Q8BHC0 / Lymphatic vessel endothelial hyaluronic acid receptor 1 / Q9Y5Y7* / lymphatic vessel endothelial hyaluronan receptor 1*  / complex / reaction






 

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