Manteia

ENSMUSG00000036091

Mus musculus

Features

Gene ID:	ENSMUSG00000036091

Biological name :	Hyal3

Synonyms :	Hyal3 / Hyaluronidase-3 / Q8VEI3

Possible biological names infered from orthology :	hyaluronoglucosaminidase 3 / O43820

Species:	Mus musculus

Chr. number:	9
Strand:	1
Band:	F1
Gene start:	107580818
Gene end:	107587359

Corresponding Affymetrix probe sets:	10588701 (MoGene1.0st) 1425877_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000117845 Ensembl peptide - ENSMUSP00000119499 Ensembl peptide - ENSMUSP00000042667 NCBI entrez gene - 109685 See in Manteia. MGI - MGI:1330288 RefSeq - NM_178020 RefSeq Peptide - NP_821139 swissprot - D3YVY7 swissprot - Q8VEI3 Ensembl - ENSMUSG00000036091

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
hyal3	ENSDARG00000036818	Danio rerio
HYAL3	ENSGALG00000029000	Gallus gallus
HYAL3	ENSG00000186792	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Hyal2 / O35632 / Hyaluronidase-2 / Q12891* / hyaluronoglucosaminidase 2*	ENSMUSG00000010047	40
Hyal5 / Q812F3 / Hyaluronidase-5 / SPAM1* / P38567* / sperm adhesion molecule 1*	ENSMUSG00000029678	40
Hyal6 / hyaluronoglucosaminidase 6	ENSMUSG00000029679	40
Hyal1 / Q91ZJ9 / Mus musculus hyaluronoglucosaminidase 1 (Hyal1), transcript variant 2, mRNA. / Q12794* / hyaluronoglucosaminidase 1*	ENSMUSG00000010051	39
Hyal4 / Q05A56 / Hyaluronidase-4 / Q2M3T9* / hyaluronoglucosaminidase 4*	ENSMUSG00000029680	37
Spam1 / P48794 / sperm adhesion molecule 1 / P38567*	ENSMUSG00000029682	36

Protein motifs (from Interpro)

Interpro ID	Name
IPR013032	EGF-like, conserved site
IPR013111	EGF-like domain, extracellular
IPR013785	Aldolase-type TIM barrel
IPR017853	Glycoside hydrolase superfamily
IPR018155	Hyaluronidase
IPR027260	Hyaluronidase-3

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001552	ovarian follicle atresia	IDA
biological_process	GO:0005975	carbohydrate metabolic process	IEA
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007338	single fertilization	IEA
biological_process	GO:0007341	penetration of zona pellucida	IMP
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0009615	response to virus	IEA
biological_process	GO:0030214	hyaluronan catabolic process	IEA
biological_process	GO:0046677	response to antibiotic	IEA
biological_process	GO:0051216	cartilage development	IEA
biological_process	GO:0071347	cellular response to interleukin-1	IEA
biological_process	GO:0071356	cellular response to tumor necrosis factor	IEA
biological_process	GO:0071493	cellular response to UV-B	IEA
biological_process	GO:2000355	negative regulation of ovarian follicle development	IDA
biological_process	GO:2000368	positive regulation of acrosomal vesicle exocytosis	IMP
cellular_component	GO:0001669	acrosomal vesicle	IEA
cellular_component	GO:0002080	acrosomal membrane	IDA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005764	lysosome	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005769	early endosome	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	ISO
cellular_component	GO:0097225	sperm midpiece	IDA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004415	hyalurononglucosaminidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA
molecular_function	GO:0033906	hyaluronoglucuronidase activity	IEA

Pathways (from Reactome)

Pathway description

CS/DS degradation

Hyaluronan uptake and degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001510	abnormal coat appearance	"coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0002276	abnormal lung interstitium morphology	"any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Apc^Min/Apc⁺,Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0006027	impaired alveologenesis	"a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]	Show Allelic Composition: Apc^Min/Apc⁺,Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0010902	abnormal pulmonary alveolar sac morphology	"any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Apc^Min/Apc⁺,Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Genetic Background: involves: 129 * C57BL/6 * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr