ENSMUSG00000010051


Mus musculus

Features
Gene ID: ENSMUSG00000010051
  
Biological name :Hyal1
  
Synonyms : Hyal1 / Mus musculus hyaluronoglucosaminidase 1 (Hyal1), transcript variant 2, mRNA. / Q91ZJ9
  
Possible biological names infered from orthology : hyaluronoglucosaminidase 1 / Q12794
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 107576927
Gene end: 107581710
  
Corresponding Affymetrix probe sets: 10588691 (MoGene1.0st)   1449954_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108006
Ensembl peptide - ENSMUSP00000122601
Ensembl peptide - ENSMUSP00000120599
Ensembl peptide - ENSMUSP00000010195
NCBI entrez gene - 15586     See in Manteia.
MGI - MGI:96298
RefSeq - NM_001331161
RefSeq - NM_008317
RefSeq Peptide - NP_001318090
RefSeq Peptide - NP_032343
swissprot - Q91ZJ9
swissprot - D3YXU8
swissprot - D6RFV7
Ensembl - ENSMUSG00000010051
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hyal1ENSDARG00000059916Danio rerio
 HYAL1ENSGALG00000000785Gallus gallus
 HYAL1ENSG00000114378Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hyal2 / O35632 / Hyaluronidase-2 / Q12891* / hyaluronoglucosaminidase 2*ENSMUSG0000001004738
Hyal4 / Q05A56 / Hyaluronidase-4 / Q2M3T9* / hyaluronoglucosaminidase 4*ENSMUSG0000002968038
Hyal5 / Q812F3 / Hyaluronidase-5 / SPAM1* / P38567* / sperm adhesion molecule 1*ENSMUSG0000002967837
Hyal6 / hyaluronoglucosaminidase 6ENSMUSG0000002967937
Hyal3 / Q8VEI3 / Hyaluronidase-3 / O43820* / hyaluronoglucosaminidase 3*ENSMUSG0000003609135
Spam1 / P48794 / sperm adhesion molecule 1 / P38567*ENSMUSG0000002968234


Protein motifs (from Interpro)
Interpro ID Name
 IPR013785  Aldolase-type TIM barrel
 IPR017853  Glycoside hydrolase superfamily
 IPR018155  Hyaluronidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0030212 hyaluronan metabolic process IEA
 biological_processGO:0030213 hyaluronan biosynthetic process IEA
 biological_processGO:0030214 hyaluronan catabolic process IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045927 positive regulation of growth IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IMP
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071467 cellular response to pH IEA
 biological_processGO:0071493 cellular response to UV-B IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:1900106 positive regulation of hyaluranon cable assembly IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036117 hyaluranon cable IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004415 hyalurononglucosaminidase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0050501 hyaluronan synthase activity IEA


Pathways (from Reactome)
Pathway description
CS/DS degradation
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Cacna2d2du-2J/Cacna2d2du-2J
Genetic Background: involves: C57BLKS/J-Cacna2d2du-2J/LetJ

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Cacna2d2du-2J/Cacna2d2du-2J
Genetic Background: involves: C57BLKS/J-Cacna2d2du-2J/LetJ

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Cacna2d2du-2J/Cacna2d2du-2J
Genetic Background: involves: C57BLKS/J-Cacna2d2du-2J/LetJ

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Cacna2d2du-2J/Cacna2d2du-2J
Genetic Background: involves: C57BLKS/J-Cacna2d2du-2J/LetJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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