ENSMUSG00000013787


Mus musculus

Features
Gene ID: ENSMUSG00000013787
  
Biological name :Ehmt2
  
Synonyms : Ehmt2 / Histone-lysine N-methyltransferase EHMT2 / Q9Z148
  
Possible biological names infered from orthology : euchromatic histone lysine methyltransferase 2 / Q96KQ7
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34898469
Gene end: 34914052
  
Corresponding Affymetrix probe sets: 10444524 (MoGene1.0st)   1426888_at (Mouse Genome 430 2.0 Array)   1460692_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121838
Ensembl peptide - ENSMUSP00000134089
Ensembl peptide - ENSMUSP00000134749
Ensembl peptide - ENSMUSP00000013931
Ensembl peptide - ENSMUSP00000077208
Ensembl peptide - ENSMUSP00000094955
Ensembl peptide - ENSMUSP00000109667
NCBI entrez gene - 110147     See in Manteia.
MGI - MGI:2148922
RefSeq - NM_147151
RefSeq - XM_011246249
RefSeq - XM_011246248
RefSeq - XM_006523482
RefSeq - NM_001286573
RefSeq - NM_001286575
RefSeq - NM_145830
RefSeq Peptide - NP_001273502
RefSeq Peptide - NP_001273504
RefSeq Peptide - NP_665829
RefSeq Peptide - NP_671493
swissprot - G3UYH7
swissprot - Q9Z148
swissprot - A2CG77
swissprot - A2CG76
swissprot - H3BIW5
Ensembl - ENSMUSG00000013787
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ehmt2ENSDARG00000102325Danio rerio
 EHMT2ENSG00000204371Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSMUSG0000003689345
Nsd1 / nuclear receptor-binding SET-domain protein 1 / Q96L73*ENSMUSG0000002148814
Nsd3 / Q6P2L6 / Histone-lysine N-methyltransferase NSD3 / Q9BZ95* / nuclear receptor binding SET domain protein 3*ENSMUSG0000005482312
Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*ENSMUSG0000005740612
Setdb1 / SET domain, bifurcated 1 / Q15047*ENSMUSG0000001569711
Ash1l / Q99MY8 / Histone-lysine N-methyltransferase ASH1L / Q9NR48* / ASH1 like histone lysine methyltransferase*ENSMUSG0000002805311
Setd2 / E9Q5F9 / Histone-lysine N-methyltransferase SETD2 / Q9BYW2* / SET domain containing 2*ENSMUSG0000004479111
Ezh1 / P70351 / Histone-lysine N-methyltransferase EZH1 / Q92800* / enhancer of zeste 1 polycomb repressive complex 2 subunit*ENSMUSG0000000692010
Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*ENSMUSG0000002968710
Q9Z180 / Setbp1 / SET-binding protein / Q9Y6X0* / SET binding protein 1*ENSMUSG000000245489
Suv39h2 / suppressor of variegation 3-9 2 / Q9H5I1* / suppressor of variegation 3-9 homolog 2*ENSMUSG000000266469
O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*ENSMUSG000000392319
Q8C267 / Setdb2 / SET domain, bifurcated 2 / Q96T68*ENSMUSG000000713509
Q80UJ9 / Setmar / Histone-lysine N-methyltransferase SETMAR / Q53H47* / SET domain and mariner transposase fusion gene*ENSMUSG000000346397


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR002110  Ankyrin repeat
 IPR007728  Pre-SET domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006275 regulation of DNA replication IMP
 biological_processGO:0006306 DNA methylation IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0007130 synaptonemal complex assembly IMP
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0009267 cellular response to starvation ISO
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010424 DNA methylation on cytosine within a CG sequence IMP
 biological_processGO:0016571 histone methylation ISO
 biological_processGO:0018027 peptidyl-lysine dimethylation ISO
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0035265 organ growth IMP
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0036166 phenotypic switching IMP
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048148 behavioral response to cocaine IMP
 biological_processGO:0048665 neuron fate specification IMP
 biological_processGO:0051567 histone H3-K9 methylation IMP
 biological_processGO:0051569 regulation of histone H3-K4 methylation IEA
 biological_processGO:0051570 regulation of histone H3-K9 methylation IEA
 biological_processGO:0060992 response to fungicide IEA
 biological_processGO:0070734 histone H3-K27 methylation IMP
 biological_processGO:0071314 cellular response to cocaine IDA
 biological_processGO:1902902 negative regulation of autophagosome assembly IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046974 histone methyltransferase activity (H3-K9 specific) EXP
 molecular_functionGO:0046976 histone methyltransferase activity (H3-K27 specific) IDA
 molecular_functionGO:0070742 C2H2 zinc finger domain binding ISO
 molecular_functionGO:1990841 promoter-specific chromatin binding ISO


Pathways (from Reactome)
Pathway description
Senescence-Associated Secretory Phenotype (SASP)
PKMTs methylate histone lysines
Regulation of TP53 Activity through Methylation
RNA Polymerase I Transcription Initiation
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: (129S4/SvJae x C57BL/6)F1

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: (129S4/SvJae x C57BL/6)F1

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: (129S4/SvJae x C57BL/6)F1

Allelic Composition: Ehmt2tm1.1Tara/Ehmt2tm1.1Tara,Tg(Drd1-cre)EY262Gsat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ehmt1tm1.1Tara/Ehmt1tm1.1Tara,Ehmt2tm1.1Tara/Ehmt2tm1.1Tara,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: (129S4/SvJae x C57BL/6)F1

Allelic Composition: Ehmt1tm1.1Tara/Ehmt1tm1.1Tara,Ehmt2tm1.1Tara/Ehmt2tm1.1Tara,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001423 abnormal liquid preference "the desire to drink more or less fluids than average, or to drink unusual fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: (129S4/SvJae x C57BL/6)F1

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Ehmt2tm1Yshk/Ehmt2tm1Yshk
Genetic Background: B6.Cg-Ehmt2tm1Yshk

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: (129S4/SvJae x C57BL/6)F1

Allelic Composition: Ehmt1tm1.1Tara/Ehmt1tm1.1Tara,Ehmt2tm1.1Tara/Ehmt2tm1.1Tara,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: B6.129P2-Il17atm1Yiw

 MP:0003787 abnormal imprinting "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ehmt2tm1.1Tara/Ehmt2tm1.1Tara,Tg(Drd1-cre)EY262Gsat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: B6.129P2-Il17atm1Yiw

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ehmt2tm1Yshk/Ehmt2tm1Yshk
Genetic Background: B6.Cg-Ehmt2tm1Yshk

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: B6.129P2-Il17atm1Yiw

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: B6.129P2-Il17atm1Yiw

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: B6.129P2-Il17atm1Yiw

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: B6.129P2-Il17atm1Yiw

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: B6.129P2-Il17atm1Yiw

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ehmt2tm1.1Tara/Ehmt2tm1.1Tara,Tg(Drd1-cre)EY262Gsat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ehmt2tm1.1Tara/Ehmt2tm1.1Tara,Tg(Drd1-cre)EY262Gsat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: (129S4/SvJae x C57BL/6)F1

Allelic Composition: Ehmt2tm1.1Tara/Ehmt2tm1.1Tara,Tg(Drd1-cre)EY262Gsat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ubl4atm1.2Arte/Ubl4atm1.2Arte
Genetic Background: involves: C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Ehmt2tm1Yshk/Ehmt2tm1Yshk
Genetic Background: B6.Cg-Ehmt2tm1Yshk

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020235 Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*  / complex / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / complex / reaction
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / complex
 ENSMUSG00000033943 Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction
 ENSMUSG00000059436 Max / Max protein / P61244* / MYC associated factor X*  / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000026803 Ttf1 / Q62187 / transcription termination factor, RNA polymerase I / Q15361* / transcription termination factor 1*  / complex / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction
 ENSMUSG00000025050 Pcgf6 / Q99NA9 / Polycomb group RING finger protein 6 / Q9BYE7* / polycomb group ring finger 6*  / complex / reaction
 ENSMUSG00000024325 Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*  / complex / reaction
 ENSMUSG00000022394 P59178 / L3mbtl2 / Lethal(3)malignant brain tumor-like protein 2 / Q969R5* / L3MBTL2, polycomb repressive complex 1 subunit*  / complex / reaction
 ENSMUSG00000029836 Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*  / complex / reaction
 ENSMUSG00000054051 Ercc6 / ERCC excision repair 6, chromatin remodeling factor / P0DP91* / Q03468* / Q8N328*  / complex
 ENSMUSG00000026484 Rnf2 / Q9CQJ4 / E3 ubiquitin-protein ligase RING2 / Q99496* / ring finger protein 2*  / complex / reaction
 ENSMUSG00000022634 Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*  / complex / reaction






 

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