ENSMUSG00000039231


Mus musculus

Features
Gene ID: ENSMUSG00000039231
  
Biological name :Suv39h1
  
Synonyms : O54864 / suppressor of variegation 3-9 1 / Suv39h1
  
Possible biological names infered from orthology : O43463 / suppressor of variegation 3-9 homolog 1
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.1
Gene start: 8061171
Gene end: 8074760
  
Corresponding Affymetrix probe sets: 10603431 (MoGene1.0st)   1427382_a_at (Mouse Genome 430 2.0 Array)   1432236_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111299
Ensembl peptide - ENSMUSP00000111300
Ensembl peptide - ENSMUSP00000111301
NCBI entrez gene - 20937     See in Manteia.
MGI - MGI:1099440
RefSeq - XM_011247453
RefSeq - NM_001290716
RefSeq - NM_011514
RefSeq - XM_006527574
RefSeq - XM_011247452
RefSeq Peptide - NP_001277645
RefSeq Peptide - NP_035644
swissprot - O54864
swissprot - A2AC19
Ensembl - ENSMUSG00000039231
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6DGD3ENSDARG00000026799Danio rerio
 suv39h1bENSDARG00000055753Danio rerio
 O43463ENSG00000101945Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Suv39h2 / suppressor of variegation 3-9 2 / Q9H5I1* / suppressor of variegation 3-9 homolog 2*ENSMUSG0000002664657
Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*ENSMUSG0000001378728
Setd2 / E9Q5F9 / Histone-lysine N-methyltransferase SETD2 / Q9BYW2* / SET domain containing 2*ENSMUSG0000004479128
Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSMUSG0000003689327
Setdb1 / SET domain, bifurcated 1 / Q15047*ENSMUSG0000001569726
Nsd1 / nuclear receptor-binding SET-domain protein 1 / Q96L73*ENSMUSG0000002148824
Ash1l / Q99MY8 / Histone-lysine N-methyltransferase ASH1L / Q9NR48* / ASH1 like histone lysine methyltransferase*ENSMUSG0000002805324
Q80UJ9 / Setmar / Histone-lysine N-methyltransferase SETMAR / Q53H47* / SET domain and mariner transposase fusion gene*ENSMUSG0000003463922
Nsd3 / Q6P2L6 / Histone-lysine N-methyltransferase NSD3 / Q9BZ95* / nuclear receptor binding SET domain protein 3*ENSMUSG0000005482322
Ezh1 / P70351 / Histone-lysine N-methyltransferase EZH1 / Q92800* / enhancer of zeste 1 polycomb repressive complex 2 subunit*ENSMUSG0000000692021
Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*ENSMUSG0000005740621
Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*ENSMUSG0000002968720
Q8C267 / Setdb2 / SET domain, bifurcated 2 / Q96T68*ENSMUSG0000007135020
Q9Z180 / Setbp1 / SET-binding protein / Q9Y6X0* / SET binding protein 1*ENSMUSG0000002454814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR001214  SET domain
 IPR003616  Post-SET domain
 IPR007728  Pre-SET domain
 IPR011381  Histone H3-K9 methyltransferase
 IPR016197  Chromo-like domain superfamily
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000183 chromatin silencing at rDNA ISO
 biological_processGO:0006323 DNA packaging TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006342 chromatin silencing TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IGI
 biological_processGO:0036123 histone H3-K9 dimethylation IMP
 biological_processGO:0036124 histone H3-K9 trimethylation IMP
 biological_processGO:0042754 negative regulation of circadian rhythm IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051567 histone H3-K9 methylation IGI
 biological_processGO:0071456 cellular response to hypoxia ISO
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000792 heterochromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005652 nuclear lamina IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005677 chromatin silencing complex IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005720 nuclear heterochromatin TAS
 cellular_componentGO:0033553 rDNA heterochromatin ISO
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008276 protein methyltransferase activity TAS
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity ISO
 molecular_functionGO:0042054 histone methyltransferase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046974 histone methyltransferase activity (H3-K9 specific) IDA
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
SIRT1 negatively regulates rRNA expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001116 small gonad "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Suv39h2tm1Jnw/Suv39h2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw,Suv39h2tm1Jnw/Suv39h2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020063 Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*  / complex / reaction
 ENSMUSG00000030888 Rrp8 / Q9DB85 / Ribosomal RNA-processing protein 8 / O43159* / ribosomal RNA processing 8*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction






 

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