ENSMUSG00000016256


Mus musculus

Features
Gene ID: ENSMUSG00000016256
  
Biological name :Ctsz
  
Synonyms : cathepsin Z / Ctsz / Q9WUU7
  
Possible biological names infered from orthology : Q9UBR2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 174427493
Gene end: 174439039
  
Corresponding Affymetrix probe sets: 10490212 (MoGene1.0st)   1417868_a_at (Mouse Genome 430 2.0 Array)   1417869_s_at (Mouse Genome 430 2.0 Array)   1417870_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016400
NCBI entrez gene - 64138     See in Manteia.
MGI - MGI:1891190
RefSeq - NM_022325
RefSeq Peptide - NP_071720
swissprot - Q545I6
swissprot - Q9WUU7
Ensembl - ENSMUSG00000016256
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctszENSDARG00000043081Danio rerio
 CTSZENSGALG00000007462Gallus gallus
 CTSZENSG00000101160Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctsc / P97821 / cathepsin C / P53634*ENSMUSG0000003056031
Ctsb / P10605 / cathepsin B / P07858*ENSMUSG0000002193923
Tinag / tubulointerstitial nephritis antigen / Q9UJW2*ENSMUSG0000003235722
Ctso / Q8BM88 / cathepsin O / P43234*ENSMUSG0000002801521
Q99JR5 / Tinagl1 / Tubulointerstitial nephritis antigen-like / Q9GZM7* / tubulointerstitial nephritis antigen like 1*ENSMUSG0000002877621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR025661  Cysteine peptidase, asparagine active site
 IPR033157  Cathepsin X


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0010757 negative regulation of plasminogen activation IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEP
 biological_processGO:1901214 regulation of neuron death IEA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0099738 cell cortex region IEA
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins
COPII-mediated vesicle transport
Lysosome Vesicle Biogenesis
Cargo concentration in the ER
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp5se/Bmp5se-15THO-I
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031980 Agt / angiotensinogen / P01019*  / reaction
 ENSMUSG00000041891 Lman1 / Q9D0F3 / Protein ERGIC-53 / P49257* / lectin, mannose binding 1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr