ENSMUSG00000028015


Mus musculus

Features
Gene ID: ENSMUSG00000028015
  
Biological name :Ctso
  
Synonyms : cathepsin O / Ctso / Q8BM88
  
Possible biological names infered from orthology : P43234
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E3
Gene start: 81932601
Gene end: 81956725
  
Corresponding Affymetrix probe sets: 10492699 (MoGene1.0st)   1433501_at (Mouse Genome 430 2.0 Array)   1443084_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029649
NCBI entrez gene - 229445     See in Manteia.
MGI - MGI:2139628
RefSeq - NM_177662
RefSeq Peptide - NP_808330
swissprot - Q8BM88
Ensembl - ENSMUSG00000028015
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctsoENSDARG00000052855Danio rerio
 CTSOENSGALG00000009373Gallus gallus
 CTSOENSG00000256043Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctsc / P97821 / cathepsin C / P53634*ENSMUSG0000003056027
Q99JR5 / Tinagl1 / Tubulointerstitial nephritis antigen-like / Q9GZM7* / tubulointerstitial nephritis antigen like 1*ENSMUSG0000002877621
Tinag / tubulointerstitial nephritis antigen / Q9UJW2*ENSMUSG0000003235721
Ctsz / Q9WUU7 / cathepsin Z / Q9UBR2*ENSMUSG0000001625620
Ctsb / P10605 / cathepsin B / P07858*ENSMUSG0000002193920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR025660  Cysteine peptidase, histidine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005764 lysosome IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0005635 decreased circulating bilirubin level "less thant the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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