ENSMUSG00000020357


Mus musculus

Features
Gene ID: ENSMUSG00000020357
  
Biological name :Flt4
  
Synonyms : Flt4 / P35917 / Vascular endothelial growth factor receptor 3
  
Possible biological names infered from orthology : fms related tyrosine kinase 4 / P35916
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.2
Gene start: 49609263
Gene end: 49652739
  
Corresponding Affymetrix probe sets: 10375578 (MoGene1.0st)   1421442_at (Mouse Genome 430 2.0 Array)   1444052_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020617
NCBI entrez gene - 14257     See in Manteia.
MGI - MGI:95561
RefSeq - NM_008029
RefSeq Peptide - NP_032055
swissprot - P35917
swissprot - Q5SU94
Ensembl - ENSMUSG00000020357
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flt4ENSDARG00000104453Danio rerio
 FLT4ENSGALG00000005802Gallus gallus
 FLT4ENSG00000037280Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdr / kinase insert domain receptor / P35968*ENSMUSG0000006296042
Flt1 / fms related tyrosine kinase 1 / P17948*ENSMUSG0000002964839
P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*ENSMUSG0000002923123
Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*ENSMUSG0000002462021
Csf1r / P09581 / Macrophage colony-stimulating factor 1 receptor / P07333* / colony stimulating factor 1 receptor*ENSMUSG0000002462121
Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSMUSG0000000567220
Flt3 / fms related tyrosine kinase 3 / P36888*ENSMUSG0000004281719
Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*ENSMUSG0000003011018
Fgfr2 / fibroblast growth factor receptor 2 isoform 3 / P21802* / fibroblast growth factor receptor 2*ENSMUSG0000003084918
Fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSMUSG0000000532017
Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*ENSMUSG0000003156517
Fgfr3 / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA. / P22607* / fibroblast growth factor receptor 3*ENSMUSG0000005425217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009137  Vascular endothelial growth factor receptor 3 (VEGFR3)
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0060312 regulation of blood vessel remodeling IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090037 positive regulation of protein kinase C signaling IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity ISO
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0036328 VEGF-C-activated receptor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
Show

Allelic Composition: Kcnq4tm1.2Tjj/Kcnq4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Kcnq4tm1.2Tjj/Kcnq4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt4tm1Ali/Flt4tm2Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

Allelic Composition: Flt4tm1.2Yhe/Flt4tm1.2Yhe
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Flt4Chy/Flt4Chy
Genetic Background: involves: C3H

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Kdrtm1.1Eia/Kdrtm1.1Eia
Genetic Background: B6.129P2-Kdrtm1.1Eia

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln
Genetic Background: involves: CD-1

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

Allelic Composition: Flt4tm2Ali/Flt4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+,Tg(HRAS)2Jic/0
Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt4tm1Ali/Flt4tm2Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ezh2tm1.1Sho/Ezh2tm1.1Sho
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Flt4tm2Ali/Flt4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002349 abnormal afferent lymphatic vessel morphology "structural anomaly in the tube entering the lymph node" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln,Flt4tm1Ali/Flt4+
Genetic Background: involves: C57BL/6

 MP:0003201 extremity edema "an accumulation of serous fluid in the limbs, paws and tail" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

 MP:0003390 lymphedema "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003659 abnormal lymph circulation "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

Allelic Composition: Flt4tm2Ali/Flt4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

 MP:0004784 abnormal anterior cardinal vein morphology "any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

 MP:0008778 lymphangiogenesis "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2+
Genetic Background: involves: C57BL/6

Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

Allelic Composition: Flt4tm1.2Yhe/Flt4tm1.2Yhe
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Flt4Chy/Flt4Chy
Genetic Background: involves: C3H

 MP:0010194 absent lymphatic vessels "absence of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ezh2tm1.1Sho/Ezh2tm1.1Sho
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Flt4tm1Ali/Flt4tm2Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Flt4tm1.2Yhe/Flt4tm1.2Yhe
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Flt4Chy/Flt4Chy
Genetic Background: involves: C3H

 MP:0010196 abnormal lymphatic vessel smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue that encompasses the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem204tm1.1Ali/Tmem204tm1.1Ali
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010200 enlarged lymphatic vessel "increased size of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Flt4tm1Ali/Flt4+,Tmem204tm1.1Ali/Tmem204tm1.1Ali
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ezh2tm1.1Sho/Ezh2tm1.1Sho
Genetic Background: involves: 129 * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

Allelic Composition: Flt4tm1Ali/Flt4tm2.1Ali,Krt19tm1(cre)Mmt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2+
Genetic Background: involves: C57BL/6

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
Show

Allelic Composition: Flt4Chy/Flt4+
Genetic Background: involves: C3H

Allelic Composition: Flt4tm2Ali/Flt4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Flt4tm1.1Ichi/Flt4+
Genetic Background: B6.Cg-Flt4tm1.1Ichi

Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Flt4tm1.1Ichi/Flt4+,Krastm1Mok/Kras+,Tg(HRAS)2Jic/0
Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

 MP:0012732 abnormal perineural vascular plexus morphology "any structural anomaly of the capillary bed that initially surrounds the relative avascular brain and spinal cord; the perineural vascular plexus (PNVP) is the precursor to the blood brain barrier formed by angioblasts which migrate away from somites and is recruited to surround the neural tube in response to VEGF; vascularization of the brain and spinal cord occurs via angiogenesis as sprouting vessels from the PNVP invade the neuroepithelium and grow inward toward the ventricular lumen" [MGI:anna]
Show

Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020357 Flt4 / P35917 / Vascular endothelial growth factor receptor 3 / P35916* / fms related tyrosine kinase 4*  / complex / reaction
 ENSMUSG00000031520 Vegfc / P97953 / vascular endothelial growth factor C / P49767*  / reaction / complex
 ENSMUSG00000031380 Vegfd / P97946 / vascular endothelial growth factor D / O43915*  / reaction / complex






 

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