ENSMUSG00000020660


Mus musculus

Features
Gene ID: ENSMUSG00000020660
  
Biological name :Pomc
  
Synonyms : P01193 / Pomc / pro-opiomelanocortin-alpha
  
Possible biological names infered from orthology : P01189 / proopiomelanocortin
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 3954951
Gene end: 3960642
  
Corresponding Affymetrix probe sets: 10394240 (MoGene1.0st)   1433800_a_at (Mouse Genome 430 2.0 Array)   1455858_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020990
Ensembl peptide - ENSMUSP00000151450
Ensembl peptide - ENSMUSP00000151504
Ensembl peptide - ENSMUSP00000151769
Ensembl peptide - ENSMUSP00000151367
NCBI entrez gene - 18976     See in Manteia.
MGI - MGI:97742
RefSeq - NM_001278582
RefSeq - NM_001278581
RefSeq - NM_001278583
RefSeq - NM_001278584
RefSeq - NM_008895
RefSeq Peptide - NP_032921
RefSeq Peptide - NP_001265511
RefSeq Peptide - NP_001265512
RefSeq Peptide - NP_001265513
RefSeq Peptide - NP_001265510
swissprot - P01193
swissprot - A0A1W2P7R2
swissprot - A0A1W2P724
Ensembl - ENSMUSG00000020660
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pomcaENSDARG00000043135Danio rerio
 pomcbENSDARG00000069307Danio rerio
 POMCENSGALG00000016600Gallus gallus
 POMCENSG00000115138Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001941  Pro-opiomelanocortin
 IPR013531  Pro-opiomelanocortin/corticotropin, ACTH, central region
 IPR013532  Opiodes neuropeptide
 IPR013593  Pro-opiomelanocortin N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006091 generation of precursor metabolites and energy ISS
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling ISO
 biological_processGO:0008217 regulation of blood pressure IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032098 regulation of appetite ISO
 biological_processGO:0032720 negative regulation of tumor necrosis factor production ISS
 biological_processGO:0033059 cellular pigmentation ISO
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0070873 regulation of glycogen metabolic process IMP
 biological_processGO:2000852 regulation of corticosterone secretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0030141 secretory granule IDA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005179 hormone activity ISO
 molecular_functionGO:0005184 neuropeptide hormone activity IBA
 molecular_functionGO:0031781 type 3 melanocortin receptor binding ISO
 molecular_functionGO:0031782 type 4 melanocortin receptor binding ISO
 molecular_functionGO:0070996 type 1 melanocortin receptor binding ISS


Pathways (from Reactome)
Pathway description
Opioid Signalling
Androgen biosynthesis
Glucocorticoid biosynthesis
G-protein activation
Peptide hormone biosynthesis
Endogenous sterols
Peptide ligand-binding receptors
G alpha (s) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

Allelic Composition: Pomctm1Sora/Pomc+
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
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Allelic Composition: Pomctm1Low/Pomc+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6N

Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu,Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low/J

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/0
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6 * Swiss albino

Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu,Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001425 alcohol consumption 
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Allelic Composition: Hcn2trls-2J/Hcn2trls-2J
Genetic Background: B6.WB-Hcn2trls-2J/J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ttnmdm/Ttnmdm
Genetic Background: involves: C57BL/6J

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu,Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low/J

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/0
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/0
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1atg-rol/Cacna1atg
Genetic Background: involves: C3H * C57BL/6 * DBA/2J * SIII

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low/J

Allelic Composition: Pomctm1Low/Pomc+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/0
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

Allelic Composition: Pomctm1Low/Pomc+,Tg(Pomc)#Low/0
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002629 hyperactivity elicited by ethanol administration 
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0002664 decreased circulating adrenocorticotropin level "decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/0
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

Allelic Composition: Pomctm1Sora/Pomc+
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003136 yellow coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: a/A,Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: a/A,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003962 abnormal adrenaline level "aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0003963 abnormal corticosterone level "anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/0
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0005128 decreased adrenocorticotropin level "decreased concentration of adrenocorticotropic hormone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/0
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0005313 absent adrenal gland "missing endocrine glands that are normally located above the kidney and responsible for hormone and epinepherine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56651]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

Allelic Composition: Pomctm1Sora/Pomc+
Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

 MP:0005661 decreased circulating adrenaline level "less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Pomctm2Ute/Pomc+
Genetic Background: involves: 129S1/SvEv * 129X1/SvJ

Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0006370 abnormal phaeomelanin content "anomaly in the amount or distribution of yellow pigment in the hair" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: a/A,Pomctm1Sora/Pomctm1Sora
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: a/A,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/0
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009302 increased renal fat pad weight 
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0011478 abnormal urine catecholamine level "any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
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Allelic Composition: Pomctm1Low/Pomctm1Low
Genetic Background: B6.129S2-Pomctm1Low

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
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Allelic Composition: Pomctm2Low/Pomctm2Low
Genetic Background: B6.129S4-Pomctm2Low

Allelic Composition: Pomctm2Low/Pomctm2Low,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000766 Oprm1 / P42866 / opioid receptor, mu 1 / P35372*  / complex / reaction
 ENSMUSG00000038537 Mc3r / P33033 / Melanocortin receptor 3 / P41968* / melanocortin 3 receptor*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000045569 Mc2r / Q64326 / melanocortin 2 receptor / Q01718*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000047259 Mc4r / P56450 / Melanocortin receptor 4 / P32245* / melanocortin 4 receptor*  / complex / reaction
 ENSMUSG00000007480 Mc5r / melanocortin 5 receptor / P33032*  / complex / reaction
 ENSMUSG00000021587 Pcsk1 / P63239 / Neuroendocrine convertase 1 / P29120* / proprotein convertase subtilisin/kexin type 1*  / reaction






 

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