ENSMUSG00000047259


Mus musculus

Features
Gene ID: ENSMUSG00000047259
  
Biological name :Mc4r
  
Synonyms : Mc4r / Melanocortin receptor 4 / P56450
  
Possible biological names infered from orthology : melanocortin 4 receptor / P32245
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E1
Gene start: 66857715
Gene end: 66860472
  
Corresponding Affymetrix probe sets: 10459512 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000054776
NCBI entrez gene - 17202     See in Manteia.
MGI - MGI:99457
RefSeq - NM_016977
RefSeq Peptide - NP_058673
swissprot - P56450
Ensembl - ENSMUSG00000047259
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mc4rENSDARG00000015515Danio rerio
 MC4RENSGALG00000012907Gallus gallus
 MC4RENSG00000166603Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mc5r / melanocortin 5 receptor / P33032*ENSMUSG0000000748059
Mc3r / P33033 / Melanocortin receptor 3 / P41968* / melanocortin 3 receptor*ENSMUSG0000003853754
Mc2r / Q64326 / melanocortin 2 receptor / Q01718*ENSMUSG0000004556943
Mc1r / Q01727 / Melanocyte-stimulating hormone receptor ENSMUSG0000007403742


Protein motifs (from Interpro)
Interpro ID Name
 IPR000155  Melanocortin 4 receptor
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001671  Melanocortin/ACTH receptor
 IPR001908  Melanocortin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002024 diet induced thermogenesis IEA
 biological_processGO:0006112 energy reserve metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0019222 regulation of metabolic process IMP
 biological_processGO:0030073 insulin secretion IGI
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0045780 positive regulation of bone resorption IMP
 biological_processGO:0060259 regulation of feeding behavior IEA
 biological_processGO:2000252 negative regulation of feeding behavior IEA
 biological_processGO:2000821 regulation of grooming behavior IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004977 melanocortin receptor activity IDA
 molecular_functionGO:0004980 melanocyte-stimulating hormone receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042923 neuropeptide binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Chattm1(cre)Lowl/Chat+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm2.1Lowl/Mc4rtm2.1Lowl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

Allelic Composition: Mc4rtm1.1Fbz/Mc4r+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mc4rI194F/Mc4rI194F
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rI194F/Mc4r+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rY302C/Mc4r+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rY302C/Mc4rY302C
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

Allelic Composition: Mc4rGlu3/Mc4rGlu3
Genetic Background: C57BL/6J-Mc4rGlu3

Allelic Composition: Mc4rGlu3/Mc4r+
Genetic Background: C57BL/6J-Mc4rGlu3

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp,Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu,Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Mc4rm2Btlr/Mc4rm2Btlr
Genetic Background: C57BL/6J-Mc4rm2Btlr

Allelic Composition: Mc4rm3Btlr/Mc4rm3Btlr
Genetic Background: C57BL/6J-Mc4rm3Btlr

Allelic Composition: Mc4rm3Btlr/Mc4r+
Genetic Background: C57BL/6J-Mc4rm3Btlr

Allelic Composition: Mc4rMhdahwe13/Mc4r+
Genetic Background: C3HeB/FeJ-Mc4rMhdahwe13

Allelic Composition: Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

Allelic Composition: Mc4rtm1.1Fbz/Mc4r+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

Allelic Composition: Mc4rM4Btlr/Mc4rM4Btlr
Genetic Background: C57BL/6J-Mc4rM4Btlr

Allelic Composition: Mc4rM4Btlr/Mc4r+
Genetic Background: C57BL/6J-Mc4rM4Btlr

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rI194F/Mc4rI194F
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rY302C/Mc4rY302C
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Tg(Sim1-cre)2Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

Allelic Composition: Mc4rGlu3/Mc4rGlu3
Genetic Background: C57BL/6J-Mc4rGlu3

Allelic Composition: Mc4rm1Btlr/Mc4rm1Btlr
Genetic Background: C57BL/6J-Mc4rm1Btlr

Allelic Composition: Mc4rtm2.1Lowl/Mc4rtm2.1Lowl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Mc4rtm1Lowl/Mc4r+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mc4rtm1Lowl/Mc4r+,Mrap2tm1.1Maj/Mrap2+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Mrap2tm1.1Maj/Mrap2tm1.1Maj
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Crhtm1.1(cre)Dolsn/Crh+,Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Pdyntm1.1(cre)Mjkr/Pdyn+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Crhtm1.1(cre)Dolsn/Crh+,Mc4rtm1Lowl/Mc4rtm1Lowl,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rargtm2Ipc/Rargtm2Ipc,Rxratm2Ipc/Rxratm2Ipc
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Htr2ctm1Knk/Y,Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu,Pomctm1Low/Pomctm1Low
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Mc4rtm2.1Lowl/Mc4rtm2.1Lowl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

Allelic Composition: Mc4rGlu3/Mc4r+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Chattm1(cre)Lowl/Chat+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Tg(Sim1-cre)2Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-EGFP/Rpl10a,-birA)Wtp/Gt(ROSA)26Sortm1.1(CAG-EGFP/Rpl10a,-birA)Wtp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

Allelic Composition: Mc4rtm2.1Lowl/Mc4rtm2.1Lowl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: B6.129S4-Mc4rtm1Dhu

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

Allelic Composition: Mc4rGlu3/Mc4r+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mc4rI194F/Mc4rI194F
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rI194F/Mc4r+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rY302C/Mc4r+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rY302C/Mc4rY302C
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc4rGlu3/Mc4rGlu3
Genetic Background: C57BL/6J-Mc4rGlu3

Allelic Composition: Mc4rtm1Lex/Mc4rtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1Knk/Y,Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006087 increased body mass index "greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009286 increased abdominal fat pad weight "greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

Allelic Composition: Mc4rtm1.1Fbz/Mc4r+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mc4rtm2.1Lowl/Mc4rtm2.1Lowl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0020386 adipose tissue inflammation "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020660 Pomc / P01193 / pro-opiomelanocortin-alpha / P01189* / proopiomelanocortin*  / complex / reaction






 

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