ENSMUSG00000021587


Mus musculus

Features
Gene ID: ENSMUSG00000021587
  
Biological name :Pcsk1
  
Synonyms : Neuroendocrine convertase 1 / P63239 / Pcsk1
  
Possible biological names infered from orthology : P29120 / proprotein convertase subtilisin/kexin type 1
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 75089826
Gene end: 75134861
  
Corresponding Affymetrix probe sets: 10406229 (MoGene1.0st)   1421396_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022075
Ensembl peptide - ENSMUSP00000152702
NCBI entrez gene - 18548     See in Manteia.
MGI - MGI:97511
RefSeq - XM_006517155
RefSeq - NM_013628
RefSeq - XM_006517153
RefSeq - XM_006517154
RefSeq Peptide - NP_038656
swissprot - Q32MU0
swissprot - A0A1Y7VJY7
swissprot - P63239
Ensembl - ENSMUSG00000021587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcsk1ENSDARG00000002600Danio rerio
 PCSK1ENSGALG00000014681Gallus gallus
 PCSK1ENSG00000175426Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*ENSMUSG0000003053042
Pcsk5 / Q04592 / Proprotein convertase subtilisin/kexin type 5 / Q92824*ENSMUSG0000002471341
Pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSMUSG0000003051340
Pcsk4 / P29121 / Proprotein convertase subtilisin/kexin type 4 / Q6UW60*ENSMUSG0000002013137
Pcsk2 / P21661 / proprotein convertase subtilisin/kexin type 2 / P16519*ENSMUSG0000002741937
Pcsk7 / Q61139 / Proprotein convertase subtilisin/kexin type 7 / Q16549*ENSMUSG0000003538234


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022005  Prohormone convertase enzyme
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0016486 peptide hormone processing IDA
 biological_processGO:0043043 peptide biosynthetic process IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Peptide hormone biosynthesis
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf10tm1Ska/Fgf10Tg(Myl3-lacZ)24Buck
Genetic Background: involves: C57BL/6 * CBA

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Pcsk1tm1b(EUCOMM)Wtsi/Pcsk1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcsk1tm1b(EUCOMM)Wtsi/Ics

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Fgf10tm1Ska/Fgf10Tg(Myl3-lacZ)24Buck
Genetic Background: involves: C57BL/6 * CBA

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Pcsk1N222D/Pcsk1N222D
Genetic Background: C57BL/6-Pcsk1N222D

Allelic Composition: Pcsk1mpc242H/Pcsk1mpc242H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf10tm1Ska/Fgf10Tg(Myl3-lacZ)24Buck
Genetic Background: involves: C57BL/6 * CBA

 MP:0001665 chronic diarrhea "prolonged diarrhea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Pcsk1N222D/Pcsk1N222D
Genetic Background: C57BL/6-Pcsk1N222D

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0004818 increased skeletal muscle mass "increase in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcsk1N222D/Pcsk1N222D
Genetic Background: C57BL/6-Pcsk1N222D

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcsk1N222D/Pcsk1N222D
Genetic Background: C57BL/6-Pcsk1N222D

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcsk1N222D/Pcsk1N222D
Genetic Background: C57BL/6-Pcsk1N222D

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcsk1mpc242H/Pcsk1mpc242H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0005128 decreased adrenocorticotropin level "decreased concentration of adrenocorticotropic hormone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcsk1N222D/Pcsk1N222D
Genetic Background: C57BL/6-Pcsk1N222D

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcsk1mpc242H/Pcsk1mpc242H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pcsk1mpc242H/Pcsk1mpc242H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Pcsk1N222D/Pcsk1N222D
Genetic Background: C57BL/6-Pcsk1N222D

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Pcsk1N222D/Pcsk1N222D
Genetic Background: C57BL/6-Pcsk1N222D

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008200 decreased follicular dendritic cell number "reduced number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008244 abnormal peritoneal macrophage morphology "any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum" [CL:0000581, MESH:A.11.329.372.630]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Plcb4tm1Dwu/Plcb4tm1Dwu
Genetic Background: involves: 129S1/Sv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nototm1Gos/Nototm1Gos
Genetic Background: involves: 129S1/SvImJ

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pcsk1tm1b(EUCOMM)Wtsi/Pcsk1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcsk1tm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020660 Pomc / P01193 / pro-opiomelanocortin-alpha / P01189* / proopiomelanocortin*  / reaction
 ENSMUSG00000064177 Ghrl / Q9EQX0 / Appetite-regulating hormone Ghrelin Obestatin / Q9UBU3* / ghrelin and obestatin prepropeptide*  / reaction
 ENSMUSG00000014351 Gip / P48756 / Gastric inhibitory polypeptide / P09681*  / reaction
 ENSMUSG00000000394 Gcg / P55095 / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like pepti...  / reaction






 

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