ENSMUSG00000020704


Mus musculus

Features
Gene ID: ENSMUSG00000020704
  
Biological name :Asic2
  
Synonyms : Acid-sensing ion channel 2 / Asic2 / Q925H0
  
Possible biological names infered from orthology : acid sensing ion channel subunit 2 / Q16515
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 80880169
Gene end: 81968457
  
Corresponding Affymetrix probe sets: 10389047 (MoGene1.0st)   1417994_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021045
Ensembl peptide - ENSMUSP00000067095
NCBI entrez gene - 11418     See in Manteia.
MGI - MGI:1100867
RefSeq - XM_006531996
RefSeq - NM_001034013
RefSeq - NM_007384
RefSeq Peptide - NP_001029185
RefSeq Peptide - NP_031410
swissprot - Q3UYD3
swissprot - Q925H0
swissprot - B2RRQ1
Ensembl - ENSMUSG00000020704
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 asic2ENSDARG00000006849Danio rerio
 ASIC2ENSGALG00000000367Gallus gallus
 ASIC2ENSG00000108684Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Asic1 / Q6NXK8 / Acid-sensing ion channel 1 / P78348* / acid sensing ion channel subunit 1*ENSMUSG0000002301754
Asic3 / Q6X1Y6 / Acid-sensing ion channel 3 / Q9UHC3* / acid sensing ion channel subunit 3*ENSMUSG0000003827643
Asic4 / Q7TNS7 / Acid-sensing ion channel 4 / Q96FT7* / acid sensing ion channel subunit family member 4*ENSMUSG0000003300741
Asic5 / Q9R0Y1 / Acid-sensing ion channel 5 / Q9NY37* / acid sensing ion channel subunit family member 5*ENSMUSG0000002800823
Q9WU38 / Scnn1b / sodium channel, nonvoltage-gated 1 beta / P51168* / sodium channel epithelial 1 beta subunit*ENSMUSG0000003087322
Q9WU39 / Scnn1g / Amiloride-sensitive sodium channel subunit gamma / P51170* / sodium channel epithelial 1 gamma subunit*ENSMUSG0000000021621
Scnn1a / sodium channel, nonvoltage-gated 1 alpha / P37088* / sodium channel epithelial 1 alpha subunit*ENSMUSG0000003034021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001873  Epithelial sodium channel
 IPR004724  Epithelial sodium channel, chordates
 IPR020903  Epithelial sodium channel, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003026 regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IMP
 biological_processGO:0006814 sodium ion transport IDA
 biological_processGO:0007602 phototransduction IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0009612 response to mechanical stimulus IMP
 biological_processGO:0010447 response to acidic pH IMP
 biological_processGO:0019229 regulation of vasoconstriction IMP
 biological_processGO:0034220 ion transmembrane transport IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IMP
 biological_processGO:0035418 protein localization to synapse IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0050915 sensory perception of sour taste ISO
 biological_processGO:0050974 detection of mechanical stimulus involved in sensory perception IMP
 biological_processGO:0051965 positive regulation of synapse assembly IMP
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005216 ion channel activity IDA
 molecular_functionGO:0005261 cation channel activity IMP
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015280 ligand-gated sodium channel activity IDA
 molecular_functionGO:0022839 ion gated channel activity IMP


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Txktm1Pls/Txktm1Pls
Genetic Background: B6.129-Txktm1Pls Itktm1Ljb

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

Allelic Composition: Asic2tm1Wsh/Asic2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themis5AT161/Themis5AT161
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006335 abnormal hearing electrophysiology "anomaly in auditory function as it relates to electrical phenomena" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020704 Asic2 / Q925H0 / Acid-sensing ion channel 2 / Q16515* / acid sensing ion channel subunit 2*  / complex
 ENSMUSG00000027744 Q6PE84 / Stoml3 / stomatin (Epb7.2)-like 3 / Q8TAV4* / stomatin like 3*  / complex / reaction






 

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