ENSMUSG00000023017


Mus musculus

Features
Gene ID: ENSMUSG00000023017
  
Biological name :Asic1
  
Synonyms : Acid-sensing ion channel 1 / Asic1 / Q6NXK8
  
Possible biological names infered from orthology : acid sensing ion channel subunit 1 / P78348
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 99670368
Gene end: 99701130
  
Corresponding Affymetrix probe sets: 10426782 (MoGene1.0st)   1455328_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023758
Ensembl peptide - ENSMUSP00000154379
NCBI entrez gene - 11419     See in Manteia.
MGI - MGI:1194915
RefSeq - XM_017316366
RefSeq - NM_001289791
RefSeq - NM_009597
RefSeq - XM_006520295
RefSeq - XM_006520297
RefSeq - XM_006520298
RefSeq Peptide - NP_033727
RefSeq Peptide - NP_001276720
swissprot - Q6NXK8
Ensembl - ENSMUSG00000023017
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 asic1aENSDARG00000008329Danio rerio
 si:dkey-57c15.1ENSDARG00000105115Danio rerio
 ASIC1ENSGALG00000034025Gallus gallus
 ASIC1ENSG00000110881Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Asic2 / Q925H0 / Acid-sensing ion channel 2 / Q16515* / acid sensing ion channel subunit 2*ENSMUSG0000002070458
Asic4 / Q7TNS7 / Acid-sensing ion channel 4 / Q96FT7* / acid sensing ion channel subunit family member 4*ENSMUSG0000003300750
Asic3 / Q6X1Y6 / Acid-sensing ion channel 3 / Q9UHC3* / acid sensing ion channel subunit 3*ENSMUSG0000003827650
Asic5 / Q9R0Y1 / Acid-sensing ion channel 5 / Q9NY37* / acid sensing ion channel subunit family member 5*ENSMUSG0000002800828
Q9WU39 / Scnn1g / Amiloride-sensitive sodium channel subunit gamma / P51170* / sodium channel epithelial 1 gamma subunit*ENSMUSG0000000021624
Q9WU38 / Scnn1b / sodium channel, nonvoltage-gated 1 beta / P51168* / sodium channel epithelial 1 beta subunit*ENSMUSG0000003087324
Scnn1a / sodium channel, nonvoltage-gated 1 alpha / P37088* / sodium channel epithelial 1 alpha subunit*ENSMUSG0000003034023


Protein motifs (from Interpro)
Interpro ID Name
 IPR001873  Epithelial sodium channel
 IPR004724  Epithelial sodium channel, chordates
 IPR020903  Epithelial sodium channel, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IMP
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0010447 response to acidic pH IMP
 biological_processGO:0015672 monovalent inorganic cation transport ISO
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0046929 negative regulation of neurotransmitter secretion IMP
 biological_processGO:0050915 sensory perception of sour taste IEA
 biological_processGO:0070207 protein homotrimerization ISS
 biological_processGO:0070588 calcium ion transmembrane transport IMP
 biological_processGO:0071467 cellular response to pH IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043197 dendritic spine ISO
 cellular_componentGO:0043198 dendritic shaft ISO
 cellular_componentGO:0045202 synapse ISO
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IMP
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015077 monovalent inorganic cation transmembrane transporter activity ISO
 molecular_functionGO:0015280 ligand-gated sodium channel activity IEA
 molecular_functionGO:0022839 ion gated channel activity IMP
 molecular_functionGO:0044736 acid-sensing ion channel activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0002807 abnormal eye blink conditioning behavior "defects in the ability of an animal to learn to blink in anticipation of an aversive stimulus (e.g., an airpuff to the eyelid) following repeated pairings with a neutral stimulus (e.g., a tone); such learning is only adaptive if the animal is able to learn the precise timing between the conditioned and unconditioned stimuli " [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0009244 abnormal acid-activated cation-mediated receptor currents "change in the measured amplitude, current density or duration of response to stimulation of acid-activated cation-mediated receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023017 Asic1 / Q6NXK8 / Acid-sensing ion channel 1 / P78348* / acid sensing ion channel subunit 1*  / complex
 ENSMUSG00000027744 Q6PE84 / Stoml3 / stomatin (Epb7.2)-like 3 / Q8TAV4* / stomatin like 3*  / complex / reaction






 

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