ENSMUSG00000020926


Mus musculus

Features
Gene ID: ENSMUSG00000020926
  
Biological name :Adam11
  
Synonyms : Adam11 / Disintegrin and metalloproteinase domain-containing protein 11 / Q9R1V4
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 11 / O75078
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 102761439
Gene end: 102780262
  
Corresponding Affymetrix probe sets: 10381619 (MoGene1.0st)   1450248_at (Mouse Genome 430 2.0 Array)   1455270_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069466
Ensembl peptide - ENSMUSP00000099370
NCBI entrez gene - 11488     See in Manteia.
MGI - MGI:1098667
RefSeq - XM_017314225
RefSeq - NM_001110778
RefSeq - NM_009613
RefSeq - XM_006532017
RefSeq - XM_006532018
RefSeq - XM_006532019
RefSeq - XM_006532020
RefSeq - XM_006532014
RefSeq - XM_006532015
RefSeq - XM_006532016
RefSeq Peptide - NP_033743
RefSeq Peptide - NP_001104248
swissprot - Q7TQG7
swissprot - Q9R1V4
Ensembl - ENSMUSG00000020926
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam11ENSDARG00000079204Danio rerio
 ADAM11ENSGALG00000035673Gallus gallus
 ADAM11ENSG00000073670Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam22 / Q9R1V6 / Disintegrin and metalloproteinase domain-containing protein 22 / Q9P0K1* / ADAM metallopeptidase domain 22*ENSMUSG0000004053753
Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*ENSMUSG0000002596451
Adam19 / O35674 / Disintegrin and metalloproteinase domain-containing protein 19 / Q9H013* / ADAM metallopeptidase domain 19*ENSMUSG0000001125631
Adam33 / Q923W9 / Disintegrin and metalloproteinase domain-containing protein 33 / Q9BZ11* / ADAM metallopeptidase domain 33*ENSMUSG0000002731830
Adam12 / Q61824 / Disintegrin and metalloproteinase domain-containing protein 12 / O43184* / ADAM metallopeptidase domain 12*ENSMUSG0000005455529
Adam15 / O88839 / Disintegrin and metalloproteinase domain-containing protein 15 / Q13444* / ADAM metallopeptidase domain 15*ENSMUSG0000002804127
Adam8 / Q05910 / Disintegrin and metalloproteinase domain-containing protein 8 / P78325* / ADAM metallopeptidase domain 8*ENSMUSG0000002547326
Adam7 / O35227 / Disintegrin and metalloproteinase domain-containing protein 7 / Q9H2U9* / ADAM metallopeptidase domain 7*ENSMUSG0000002205625
Adam28 / Q9JLN6 / Disintegrin and metalloproteinase domain-containing protein 28 / Q9UKQ2* / ADAM metallopeptidase domain 28*ENSMUSG0000001472524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008237 metallopeptidase activity IEA


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036560 Lgi4 / Q8K1S1 / Leucine-rich repeat LGI family member 4 / Q8N135*  / complex / reaction
 ENSMUSG00000067242 Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*  / complex / reaction






 

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