ENSMUSG00000020974


Mus musculus

Features
Gene ID: ENSMUSG00000020974
  
Biological name :Pole2
  
Synonyms : O54956 / Pole2 / polymerase (DNA directed), epsilon 2 (p59 subunit)
  
Possible biological names infered from orthology : DNA polymerase epsilon 2, accessory subunit / P56282
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C2
Gene start: 69201773
Gene end: 69228195
  
Corresponding Affymetrix probe sets: 10400649 (MoGene1.0st)   1427094_at (Mouse Genome 430 2.0 Array)   1431440_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021359
Ensembl peptide - ENSMUSP00000152262
NCBI entrez gene - 18974     See in Manteia.
MGI - MGI:1197514
RefSeq - XM_011244018
RefSeq - NM_011133
RefSeq - XM_006515598
RefSeq - XM_006515599
RefSeq Peptide - NP_035263
swissprot - A0A1Y7VN66
swissprot - O54956
Ensembl - ENSMUSG00000020974
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pole2ENSDARG00000100028Danio rerio
 POLE2ENSGALG00000012237Gallus gallus
 POLE2ENSG00000100479Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC099934.2 / POLE2* / P56282* / DNA polymerase epsilon 2, accessory subunit*ENSMUSG0000011378616


Protein motifs (from Interpro)
Interpro ID Name
 IPR007185  DNA polymerase alpha/epsilon, subunit B
 IPR016266  DNA polymerase epsilon, subunit B
 IPR024639  DNA polymerase epsilon subunit B, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication IBA
 biological_processGO:0042276 error-prone translesion synthesis IBA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0008622 epsilon DNA polymerase complex ISO
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Telomere C-strand synthesis initiation
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007080 Pole / Q9WVF7 / polymerase (DNA directed), epsilon / Q07864* / DNA polymerase epsilon, catalytic subunit*  / complex
 ENSMUSG00000006678 Pola1 / P33609 / polymerase (DNA directed), alpha 1 / P09884* / DNA polymerase alpha 1, catalytic subunit*  / complex / reaction
 ENSMUSG00000026134 Prim2 / P33610 / DNA primase large subunit / P49643* / DNA primase subunit 2*  / complex / reaction
 ENSMUSG00000024833 Pola2 / P33611 / polymerase (DNA directed), alpha 2 / Q14181* / DNA polymerase alpha 2, accessory subunit*  / complex / reaction
 ENSMUSG00000025395 Prim1 / P20664 / DNA primase, p49 subunit / P49642* / DNA primase subunit 1*  / complex / reaction
 ENSMUSG00000028394 Pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit) / Q9NRF9* / DNA polymerase epsilon 3, accessory subunit*  / complex
 ENSMUSG00000030042 Pole4 / Q9CQ36 / polymerase (DNA-directed), epsilon 4 (p12 subunit) / Q9NR33* / DNA polymerase epsilon 4, accessory subunit*  / complex






 

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