ENSMUSG00000021381


Mus musculus

Features
Gene ID: ENSMUSG00000021381
  
Biological name :Barx1
  
Synonyms : Barx1 / Homeobox protein BarH-like 1 / Q9ER42
  
Possible biological names infered from orthology : BARX homeobox 1 / Q9HBU1
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 48662998
Gene end: 48666507
  
Corresponding Affymetrix probe sets: 10404982 (MoGene1.0st)   1423342_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021813
NCBI entrez gene - 12022     See in Manteia.
MGI - MGI:103124
RefSeq - NM_007526
RefSeq Peptide - NP_031552
swissprot - Q9ER42
Ensembl - ENSMUSG00000021381
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 barx1ENSDARG00000007407Danio rerio
 BARX1ENSGALG00000035557Gallus gallus
 BARX1ENSG00000131668Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203344
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436028
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438427
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937725
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680524
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050723
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560823
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521622
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518722
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521521
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061020
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832720
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498619
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496819
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130919
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367219


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007267 cell-cell signaling IMP
 biological_processGO:0009888 tissue development IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IMP
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048513 animal organ development IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048856 anatomical structure development IMP
 biological_processGO:0055123 digestive system development IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Npy1rtm1.1Ceva/Npy1rtm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npy1rtm1.1Ceva/Npy1rtm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0000118 arrest of tooth development "failure of differentiation of the teeth" [J:18378]
Show

Allelic Composition: Npy1rtm1.1Ceva/Npy1rtm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

Allelic Composition: Barx1tm1Shiv/Barx1tm1Shiv,Msx1tm1Bero/Msx1+
Genetic Background: involves: 129P2/OlaHsd * various

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npy1rtm1.1Ceva/Npy1rtm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npy1rtm1.1Ceva/Npy1rtm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: CrygeADD15306/CrygeADD15306
Genetic Background: involves: 102/El * C3H * T STOCK

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Npy1rtm1.1Ceva/Npy1rtm1.1Ceva,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: CrygeADD15306/CrygeADD15306
Genetic Background: involves: 102/El * C3H * T STOCK

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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