ENSMUSG00000039377


Mus musculus

Features
Gene ID: ENSMUSG00000039377
  
Biological name :Hlx
  
Synonyms : H2.0-like homeobox protein / Hlx / Q61670
  
Possible biological names infered from orthology : H2.0 like homeobox / Q14774
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H5
Gene start: 184727140
Gene end: 184732619
  
Corresponding Affymetrix probe sets: 10360834 (MoGene1.0st)   1418939_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040505
Ensembl peptide - ENSMUSP00000134728
NCBI entrez gene - 15284     See in Manteia.
MGI - MGI:96109
RefSeq - NM_008250
RefSeq Peptide - NP_032276
swissprot - G3V024
swissprot - Q549B7
swissprot - Q61670
Ensembl - ENSMUSG00000039377
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hlx1ENSDARG00000009134Danio rerio
 HLXENSGALG00000037257Gallus gallus
 HLXENSG00000136630Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050721
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560818
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518717
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498615
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130915
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521614
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203314
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438414
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436014
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367214
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138113
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680512
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061012
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832712
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521511
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IMP
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation IMP
 biological_processGO:0046622 positive regulation of organ growth IMP
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0048513 animal organ development IMP
 biological_processGO:0048557 embryonic digestive tract morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

Allelic Composition: Hlxtm1Rph/Hlxtm1Rph
Genetic Background: FVB.129P2-Hlxtm1Rph

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hlxtm1Rph/Hlxtm1Rph
Genetic Background: FVB.129P2-Hlxtm1Rph

Allelic Composition: Hlxtm1Rph/Hlxtm1Rph,Tg(DBHn-lacZ)8Rpk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hlxtm1Rph/Hlxtm1Rph
Genetic Background: FVB.129P2-Hlxtm1Rph

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0003250 absent gall bladder "absence of the organ which serves as a storage reservoir for bile" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hlxtm1Rph/Hlxtm1Rph
Genetic Background: FVB.129P2-Hlxtm1Rph

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hlxtm1Rph/Hlxtm1Rph
Genetic Background: FVB.129P2-Hlxtm1Rph

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hlxtm1Rph/Hlxtm1Rph
Genetic Background: FVB.129P2-Hlxtm1Rph

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Hlxtm1Rph/Hlxtm1Rph
Genetic Background: FVB.129P2-Hlxtm1Rph

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0012235 abnormal liver bud morphology "any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [MGI:anna]
Show

Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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