ENSMUSG00000021720


Mus musculus

Features
Gene ID: ENSMUSG00000021720
  
Biological name :Rnf180
  
Synonyms : E3 ubiquitin-protein ligase RNF180 / Q3U827 / Rnf180
  
Possible biological names infered from orthology : Q86T96 / ring finger protein 180
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 105130001
Gene end: 105294815
  
Corresponding Affymetrix probe sets: 10411958 (MoGene1.0st)   1438306_at (Mouse Genome 430 2.0 Array)   1453857_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153051
Ensembl peptide - ENSMUSP00000153506
Ensembl peptide - ENSMUSP00000153678
Ensembl peptide - ENSMUSP00000064624
Ensembl peptide - ENSMUSP00000153478
NCBI entrez gene - 71816     See in Manteia.
MGI - MGI:1919066
RefSeq - XM_017315607
RefSeq - NM_027934
RefSeq - XM_006517761
RefSeq - XM_006517762
RefSeq - XM_011244696
RefSeq - XM_006517756
RefSeq - XM_006517757
RefSeq - XM_006517759
RefSeq - XM_006517760
RefSeq Peptide - NP_082210
swissprot - Q3U827
swissprot - A0A286YCL6
Ensembl - ENSMUSG00000021720
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf180ENSDARG00000057101Danio rerio
 RNF180ENSDARG00000073720Danio rerio
 RNF180ENSGALG00000014743Gallus gallus
 Q86T96ENSG00000164197Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR033263  E3 ubiquitin-protein ligase RNF180


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0042415 norepinephrine metabolic process IMP
 biological_processGO:0042428 serotonin metabolic process IMP
 biological_processGO:0050790 regulation of catalytic activity IMP
 biological_processGO:1901360 organic cyclic compound metabolic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031227 intrinsic component of endoplasmic reticulum membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0012574 decreased noradrenaline level "reduced amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine" [http://orcid.org/0000-0001-5208-3432, ISBN:0198506732]
Show

Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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