ENSMUSG00000022623


Mus musculus

Features
Gene ID: ENSMUSG00000022623
  
Biological name :Shank3
  
Synonyms : Q4ACU6 / SH3 and multiple ankyrin repeat domains protein 3 / Shank3
  
Possible biological names infered from orthology : SH3 and multiple ankyrin repeat domains 3
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E3
Gene start: 89499623
Gene end: 89560261
  
Corresponding Affymetrix probe sets: 10426261 (MoGene1.0st)   1419137_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048062
Ensembl peptide - ENSMUSP00000132229
Ensembl peptide - ENSMUSP00000154842
Ensembl peptide - ENSMUSP00000155608
Ensembl peptide - ENSMUSP00000104932
NCBI entrez gene - 58234     See in Manteia.
MGI - MGI:1930016
RefSeq - XM_017316717
RefSeq - XM_006521224
RefSeq - XM_017316714
RefSeq - XM_017316715
RefSeq - XM_017316716
RefSeq - NM_021423
RefSeq - XM_006521220
RefSeq - XM_006521221
RefSeq - XM_006521222
RefSeq - XM_006521223
RefSeq Peptide - NP_067398
swissprot - E9Q1P5
swissprot - A0A0A0MQD5
swissprot - Q4ACU6
Ensembl - ENSMUSG00000022623
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shank3aENSDARG00000063332Danio rerio
 shank3bENSDARG00000063054Danio rerio
 ENSGALG00000039165Gallus gallus
 SHANK3ENSG00000251322Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
D3YZU1 / Shank1 / SH3 and multiple ankyrin repeat domains protein 1 / Q9Y566* / SH3 and multiple ankyrin repeat domains 1*ENSMUSG0000003873844
Q80Z38 / Shank2 / SH3 and multiple ankyrin repeat domains protein 2 / Q9UPX8* / SH3 and multiple ankyrin repeat domains 2*ENSMUSG0000003754134


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR032425  Talin, N-terminal F0 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IGI
 biological_processGO:0001838 embryonic epithelial tube formation IGI
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0021773 striatal medium spiny neuron differentiation IMP
 biological_processGO:0030534 adult behavior ISO
 biological_processGO:0032232 negative regulation of actin filament bundle assembly IDA
 biological_processGO:0035176 social behavior ISO
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0035641 locomotory exploration behavior IMP
 biological_processGO:0040011 locomotion IMP
 biological_processGO:0042297 vocal learning ISO
 biological_processGO:0045794 negative regulation of cell volume IMP
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0048170 positive regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0051835 positive regulation of synapse structural plasticity IMP
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060292 long term synaptic depression IMP
 biological_processGO:0060997 dendritic spine morphogenesis IMP
 biological_processGO:0060999 positive regulation of dendritic spine development IMP
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IMP
 biological_processGO:0071625 vocalization behavior ISO
 biological_processGO:0097107 postsynaptic density assembly IMP
 biological_processGO:0097113 AMPA glutamate receptor clustering IMP
 biological_processGO:0097114 NMDA glutamate receptor clustering IMP
 biological_processGO:0097117 guanylate kinase-associated protein clustering IMP
 biological_processGO:1900271 regulation of long-term synaptic potentiation IMP
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IMP
 biological_processGO:1900451 positive regulation of glutamate receptor signaling pathway IMP
 biological_processGO:1900452 regulation of long term synaptic depression IMP
 biological_processGO:1904717 regulation of AMPA glutamate receptor clustering IMP
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IMP
 biological_processGO:2000821 regulation of grooming behavior IMP
 biological_processGO:2000822 regulation of behavioral fear response IMP
 biological_processGO:2000969 positive regulation of AMPA receptor activity IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044309 neuron spine IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060076 excitatory synapse IC
 cellular_componentGO:0060170 ciliary membrane ISS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0017124 SH3 domain binding ISS
 molecular_functionGO:0030160 GKAP/Homer scaffold activity ISS
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IPI
 molecular_functionGO:0043621 protein self-association ISS
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0000833 thalamus hyperplasia "increased cell number in the thalamus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49481]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: B6N.Cg-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp3hith2/Casp3hith2
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: C57BL/6-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: B6N.Cg-Shank3tm1.2Bux

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: B6N.Cg-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: B6N.Cg-Shank3tm1.2Bux

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: B6N.Cg-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Casp3hith2/Casp3hith2
Genetic Background: involves: A/J * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Casp3hith2/Casp3hith2
Genetic Background: involves: A/J * FVB/N

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: C57BL/6-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Casp3hith2/Casp3hith2
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp3hith2/Casp3hith2
Genetic Background: involves: A/J * FVB/N

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX-LRAP)9Gibs/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: B6N.Cg-Shank3tm1.2Bux

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0002806 abnormal conditioned emotional response "defects in an emotional response that has been acquired by conditioning " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: C57BL/6-Shank3tm1.2Bux

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: B6N.Cg-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: C57BL/6-Shank3tm1.2Bux

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: C57BL/6-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: C57BL/6-Shank3tm1.2Bux

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: B6N.Cg-Shank3tm1.2Bux

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0008232 abnormal cingulum morphology "any structural anomaly of the white matter fiber bundle that projects from the cingulate gyrus to the entorhinal cortex in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0008462 abnormal medium spiny neuron morphology "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.1Pfw/Shank3+
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0009562 abnormal odor adaptation "altered ability or failure of the olfactory receptor neurons to adapt to ambient conditions by time-dependent modification in the sensitivity to a given odorant stimulus, as seen in the decline of the sensory response during prolonged odor stimulation; a major mechanism for the rapid calcium-calmodulin-mediated desensitization of the CNG channel" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0009694 abnormal spinal cord commissure morphology "any structural anomaly of any of the nerve fiber tracts that span the midline of the spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1Yhj/Shank3tm1Yhj
Genetic Background: B6.129S7-Shank3tm1Yhj

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0009944 abnormal olfactory lobe morphology 
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0009976 abnormal cerebellar peduncle morphology "any structural anomaly of any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: 129S6.B6(Cg)-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.2Bux/Shank3tm1.2Bux
Genetic Background: B6N.Cg-Shank3tm1.2Bux

 MP:0011000 abnormal allogrooming behavior "defects in the standard of behavior in which individuals in a cohort clean or maintain one another s outer body or appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shank3tm3.1Gfng/Shank3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm5.1Gfng/Shank3tm5.1Gfng,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Shank3tm4.1Gfng/Shank3tm4.1Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012013 abnormal innate avoidance response "any anomaly in the naive behavioral response of an individual to an aversive stimulus, in which the tendency to act defensively is stronger than the tendency to attack" [MGI:smb, NBO:0000635]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

Allelic Composition: Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic Background: B6J.129S6-Shank3tm1Cmpl

 MP:0012315 impaired learning "impaired ability to aquire lasting change in behavior that is the result of experience" [http:psychology.about.com/od/lindex/g/learning.htm]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0012480 decreased amygdala size "reduced size of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [ISBN:0-683-40008-8]
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Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0013787 photophobia " abnormal aversion or avoidance behavior in response to light; photophobia is symptom of abnormal intolerance to visual perception of light; as a medical symptom, photophobia is not a morbid fear or phobia, but an experience of discomfort or pain to the eyes due to light exposure or by presence of actual physical sensitivity of the eyes" [http://en.wikipedia.org/wiki/Photophobia, MGI:Anna]
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Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Shank3tm1.2Bux/Shank3+
Genetic Background: C57BL/6-Shank3tm1.2Bux

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: B6.129S7(C)-Shank3tm1.2Yhj

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
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Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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