ENSMUSG00000038738


Mus musculus

Features
Gene ID: ENSMUSG00000038738
  
Biological name :Shank1
  
Synonyms : D3YZU1 / SH3 and multiple ankyrin repeat domains protein 1 / Shank1
  
Possible biological names infered from orthology : Q9Y566 / SH3 and multiple ankyrin repeat domains 1
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 44310253
Gene end: 44360572
  
Corresponding Affymetrix probe sets: 10552632 (MoGene1.0st)   1444240_at (Mouse Genome 430 2.0 Array)   1447771_at (Mouse Genome 430 2.0 Array)   1458662_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103567
Ensembl peptide - ENSMUSP00000103571
Ensembl peptide - ENSMUSP00000103568
NCBI entrez gene - 243961     See in Manteia.
MGI - MGI:3613677
RefSeq - XM_006540868
RefSeq - XM_006540864
RefSeq - XM_006540865
RefSeq - XM_006540866
RefSeq - XM_006540867
RefSeq - NM_001034115
RefSeq Peptide - NP_001029287
swissprot - D3YZU4
swissprot - D3YZU1
swissprot - D3YZU5
Ensembl - ENSMUSG00000038738
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shank1ENSDARG00000060539Danio rerio
 Q9Y566ENSG00000161681Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q4ACU6 / Shank3 / SH3 and multiple ankyrin repeat domains protein 3 / SH3 and multiple ankyrin repeat domains 3*ENSMUSG0000002262335
Q80Z38 / Shank2 / SH3 and multiple ankyrin repeat domains protein 2 / Q9UPX8* / SH3 and multiple ankyrin repeat domains 2*ENSMUSG0000003754127


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR032425  Talin, N-terminal F0 domain
 IPR035735  Shank1, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030534 adult behavior IEA
 biological_processGO:0032232 negative regulation of actin filament bundle assembly IDA
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0035418 protein localization to synapse IMP
 biological_processGO:0042048 olfactory behavior IMP
 biological_processGO:0046959 habituation IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0050894 determination of affect IEA
 biological_processGO:0060013 righting reflex IMP
 biological_processGO:0060074 synapse maturation IEA
 biological_processGO:0060997 dendritic spine morphogenesis IMP
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0071625 vocalization behavior IMP
 biological_processGO:0099562 maintenance of postsynaptic density structure IEA
 biological_processGO:2000311 regulation of AMPA receptor activity IMP
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0060076 excitatory synapse IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IEA
 molecular_functionGO:0030160 GKAP/Homer scaffold activity IMP
 molecular_functionGO:0031877 somatostatin receptor binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding ISS
 molecular_functionGO:0071532 ankyrin repeat binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA
 molecular_functionGO:0098919 structural constituent of postsynaptic density IC


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-8J/Agtpbp1pcd-8J
Genetic Background: BALB/cJ-Agtpbp1pcd-8J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020476 Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*  / complex / reaction
 ENSMUSG00000061689 B1AZP2 / Dlgap4 / Disks large-associated protein 4 / Q9Y2H0* / DLG associated protein 4*  / complex
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000047495 Dlgap2 / Q8BJ42 / Disks large-associated protein 2 / Q9P1A6* / DLG associated protein 2*  / complex
 ENSMUSG00000042388 Dlgap3 / Q6PFD5 / Disks large-associated protein 3 / O95886* / DLG associated protein 3*  / complex
 ENSMUSG00000051790 Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*  / complex
 ENSMUSG00000031302 Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*  / complex
 ENSMUSG00000003279 Dlgap1 / Q9D415 / Mus musculus DLG associated protein 1 (Dlgap1), transcript variant 6, mRNA. / O14490* / DLG associated protein 1*  / complex
 ENSMUSG00000063887 Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*  / complex
 ENSMUSG00000052572 Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*  / complex






 

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