ENSMUSG00000042388


Mus musculus

Features
Gene ID: ENSMUSG00000042388
  
Biological name :Dlgap3
  
Synonyms : Disks large-associated protein 3 / Dlgap3 / Q6PFD5
  
Possible biological names infered from orthology : DLG associated protein 3 / O95886
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 127169204
Gene end: 127237022
  
Corresponding Affymetrix probe sets: 10508253 (MoGene1.0st)   1436381_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039724
Ensembl peptide - ENSMUSP00000101698
Ensembl peptide - ENSMUSP00000101700
NCBI entrez gene - 242667     See in Manteia.
MGI - MGI:3039563
RefSeq - XM_011240537
RefSeq - NM_001302081
RefSeq - NM_198618
RefSeq - XM_006503104
RefSeq - XM_006503105
RefSeq Peptide - NP_001289010
RefSeq Peptide - NP_941020
swissprot - Q3TY61
swissprot - Q6PFD5
swissprot - B1AS06
Ensembl - ENSMUSG00000042388
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlgap3ENSDARG00000055459Danio rerio
 DLGAP3ENSGALG00000032980Gallus gallus
 DLGAP3ENSG00000116544Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dlgap2 / Q8BJ42 / Disks large-associated protein 2 / Q9P1A6* / DLG associated protein 2*ENSMUSG0000004749548
Dlgap1 / Q9D415 / Mus musculus DLG associated protein 1 (Dlgap1), transcript variant 6, mRNA. / O14490* / DLG associated protein 1*ENSMUSG0000000327940
B1AZP2 / Dlgap4 / Disks large-associated protein 4 / Q9Y2H0* / DLG associated protein 4*ENSMUSG0000006168937
Dlgap5 / DLG associated protein 5 / Q15398*ENSMUSG0000003754411


Protein motifs (from Interpro)
Interpro ID Name
 IPR005026  SAPAP family
 IPR030526  Disks large-associated protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0023052 signaling IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0001540 amyloid-beta binding IDA
 molecular_functionGO:0019904 protein domain specific binding IBA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0003234 enhanced NMDA-mediated synaptic currents "increase in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex
 ENSMUSG00000020476 Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000051790 Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*  / complex
 ENSMUSG00000031302 Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*  / complex
 ENSMUSG00000063887 Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*  / complex
 ENSMUSG00000037541 Q80Z38 / Shank2 / SH3 and multiple ankyrin repeat domains protein 2 / Q9UPX8* / SH3 and multiple ankyrin repeat domains 2*  / complex
 ENSMUSG00000052572 Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*  / complex
 ENSMUSG00000038738 D3YZU1 / Shank1 / SH3 and multiple ankyrin repeat domains protein 1 / Q9Y566* / SH3 and multiple ankyrin repeat domains 1*  / complex






 

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