ENSMUSG00000051790


Mus musculus

Features
Gene ID: ENSMUSG00000051790
  
Biological name :Nlgn2
  
Synonyms : Neuroligin-2 / Nlgn2 / Q69ZK9
  
Possible biological names infered from orthology : Q8NFZ4
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69823122
Gene end: 69837784
  
Corresponding Affymetrix probe sets: 10387659 (MoGene1.0st)   1455143_at (Mouse Genome 430 2.0 Array)   1460013_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053097
Ensembl peptide - ENSMUSP00000104274
Ensembl peptide - ENSMUSP00000120428
NCBI entrez gene - 216856     See in Manteia.
MGI - MGI:2681835
RefSeq - XM_006532903
RefSeq - NM_198862
RefSeq - XM_006532901
RefSeq - XM_006532902
RefSeq Peptide - NP_942562
swissprot - F6VE93
swissprot - Q69ZK9
Ensembl - ENSMUSG00000051790
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlgn2aENSDARG00000077329Danio rerio
 nlgn2bENSDARG00000079251Danio rerio
 NLGN2ENSG00000169992Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*ENSMUSG0000003130264
Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*ENSMUSG0000006388764
Ache / P21836 / acetylcholinesterase / P22303* / acetylcholinesterase (Cartwright blood group)*ENSMUSG0000002332824
Bche / Q03311 / Cholinesterase / P06276* / butyrylcholinesterase*ENSMUSG0000002779223
Cel / Q64285 / Bile salt-activated lipase / carboxyl ester lipase*ENSMUSG0000002681822
Ces2g / carboxylesterase 2G / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003187722
Ces2e / Q8BK48 / Pyrethroid hydrolase Ces2e / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003188622
Ces2b / carboxyesterase 2B / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005009722
Ces2a / Q8QZR3 / Pyrethroid hydrolase Ces2a / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005573022
Ces5a / Q6AW46 / Carboxylesterase 5A / Q6NT32*ENSMUSG0000005801922
Ces4a / Q8R0W5 / Carboxylesterase 4A / Q5XG92*ENSMUSG0000006056022
Ces2c / Q91WG0 / Acylcarnitine hydrolase / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006182522
Ces3a / Q63880 / Carboxylesterase 3A / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006992222
Ces1h / carboxylesterase 1HENSMUSG0000007415622
Ces1b / carboxylesterase 1BENSMUSG0000007896422
Ces2h / carboxylesterase 2H / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000009181322
Ces1f / Q91WU0 / Carboxylesterase 1F ENSMUSG0000003172521
Ces1d / Q8VCT4 / Carboxylesterase 1D ENSMUSG0000005697321
Ces1g / Q8VCC2 / Liver carboxylesterase 1 ENSMUSG0000005707421
Ces1c / P23953 / Carboxylesterase 1C ENSMUSG0000005740021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000460  Neuroligin
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR029058  Alpha/Beta hydrolase fold
 IPR030023  Neuroligin-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001966 thigmotaxis ISS
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IGI
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007158 neuron cell-cell adhesion IBA
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0007630 jump response ISS
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IMP
 biological_processGO:0035176 social behavior ISS
 biological_processGO:0035418 protein localization to synapse IDA
 biological_processGO:0035641 locomotory exploration behavior IMP
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0051965 positive regulation of synapse assembly ISS
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0072553 terminal button organization ISS
 biological_processGO:0097104 postsynaptic membrane assembly IDA
 biological_processGO:0097105 presynaptic membrane assembly IMP
 biological_processGO:0097116 gephyrin clustering involved in postsynaptic density assembly IDA
 biological_processGO:0097119 postsynaptic density protein 95 clustering IDA
 biological_processGO:0097151 positive regulation of inhibitory postsynaptic potential IMP
 biological_processGO:1902474 positive regulation of protein localization to synapse IEA
 biological_processGO:1904862 inhibitory synapse assembly IDA
 biological_processGO:2000311 regulation of AMPA receptor activity IMP
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IMP
 biological_processGO:2000809 positive regulation of synaptic vesicle clustering IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060076 excitatory synapse IC
 cellular_componentGO:0060077 inhibitory synapse IEA
 cellular_componentGO:0099055 integral component of postsynaptic membrane ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042043 neurexin family protein binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0050839 cell adhesion molecule binding IPI
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IBA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Pou3f4tm1Tno/Pou3f4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0002068 abnormal parental behavior "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4tm1Tno/Pou3f4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pou3f4tm1Tno/Pou3f4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud
Genetic Background: involves: C57BL/6NTac

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud
Genetic Background: involves: C57BL/6NTac

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0010746 abnormal pre-Botzinger complex physiology "any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0011269 increased excitatory postsynaptic current amplitude "increase in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex
 ENSMUSG00000020476 Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000061689 B1AZP2 / Dlgap4 / Disks large-associated protein 4 / Q9Y2H0* / DLG associated protein 4*  / complex
 ENSMUSG00000026383 Q8BGS1 / Epb41l5 / Band 4.1-like protein 5 / Q9HCM4* / erythrocyte membrane protein band 4.1 like 5*  / complex / reaction
 ENSMUSG00000031012 Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*  / complex / reaction
 ENSMUSG00000047495 Dlgap2 / Q8BJ42 / Disks large-associated protein 2 / Q9P1A6* / DLG associated protein 2*  / complex
 ENSMUSG00000028906 Epb41 / P48193 / erythrocyte membrane protein band 4.1 / P11171*  / complex / reaction
 ENSMUSG00000042388 Dlgap3 / Q6PFD5 / Disks large-associated protein 3 / O95886* / DLG associated protein 3*  / complex
 ENSMUSG00000019978 O70318 / Epb41l2 / Mus musculus erythrocyte membrane protein band 4.1 like 2 (Epb41l2), transcript variant 3, mRNA. / O43491* / erythrocyte membrane protein band 4.1 like 2*  / complex / reaction
 ENSMUSG00000051790 Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*  / complex
 ENSMUSG00000003279 Dlgap1 / Q9D415 / Mus musculus DLG associated protein 1 (Dlgap1), transcript variant 6, mRNA. / O14490* / DLG associated protein 1*  / complex
 ENSMUSG00000024044 Q9WV92 / Epb41l3 / Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed / Q9Y2J2* / erythrocyte membrane protein band 4.1 like 3*  / complex / reaction
 ENSMUSG00000037541 Q80Z38 / Shank2 / SH3 and multiple ankyrin repeat domains protein 2 / Q9UPX8* / SH3 and multiple ankyrin repeat domains 2*  / complex
 ENSMUSG00000052572 Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*  / complex
 ENSMUSG00000038738 D3YZU1 / Shank1 / SH3 and multiple ankyrin repeat domains protein 1 / Q9Y566* / SH3 and multiple ankyrin repeat domains 1*  / complex






 

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