ENSMUSG00000022722


Mus musculus

Features
Gene ID: ENSMUSG00000022722
  
Biological name :Arl6
  
Synonyms : ADP-ribosylation factor-like protein 6 / Arl6 / O88848
  
Possible biological names infered from orthology : ADP ribosylation factor like GTPase 6 / Q9H0F7
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C1.3
Gene start: 59612949
Gene end: 59639391
  
Corresponding Affymetrix probe sets: 10440206 (MoGene1.0st)   1417331_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123287
Ensembl peptide - ENSMUSP00000023405
Ensembl peptide - ENSMUSP00000097238
Ensembl peptide - ENSMUSP00000113127
NCBI entrez gene - 56297     See in Manteia.
MGI - MGI:1927136
RefSeq - NM_019665
RefSeq - XM_006522398
RefSeq Peptide - NP_062639
RefSeq Peptide - NP_001334173
swissprot - O88848
swissprot - Q3TUM2
swissprot - D3Z067
Ensembl - ENSMUSG00000022722
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arl6ENSDARG00000032056Danio rerio
 ARL6ENSGALG00000019215Gallus gallus
 ARL6ENSG00000113966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arl5b / ADP ribosylation factor like GTPase 5B / Q96KC2*ENSMUSG0000001741836
Arl5a / Q80ZU0 / ADP-ribosylation factor-like protein 5A / Q9Y689* / ADP ribosylation factor like GTPase 5A*ENSMUSG0000003609336
Arl5c / Q6P068 / ADP-ribosylation factor-like protein 5C / A6NH57* / ADP ribosylation factor like GTPase 5C*ENSMUSG0000003835235
Arl1 / P61211 / ADP-ribosylation factor-like protein 1 / P40616* / ADP ribosylation factor like GTPase 1*ENSMUSG0000006090435


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006471 protein ADP-ribosylation ISS
 biological_processGO:0006612 protein targeting to membrane ISS
 biological_processGO:0007265 Ras protein signal transduction ISS
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008589 regulation of smoothened signaling pathway IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0045444 fat cell differentiation IEP
 biological_processGO:0051258 protein polymerization ISS
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:0061512 protein localization to cilium ISO
 biological_processGO:0097499 protein localization to non-motile cilium IDA
 biological_processGO:1903445 protein transport from ciliary membrane to plasma membrane IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005879 axonemal microtubule ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium ISO
 cellular_componentGO:0005930 axoneme ISS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030117 membrane coat ISS
 cellular_componentGO:0034464 BBSome ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0005543 phospholipid binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
BBSome-mediated cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0002200 abnormal brain ventricle/choroid plexus morphology "malformation or absence of the brain ventricles or their associated choroid plexuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0008581 disorganized photoreceptor inner segment "derangement of the pattern of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pclotm3.3Sud/Pclotm3.3Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008583 absent photoreceptor inner segment "absence of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0011056 abnormal brain ependyma motile cilium morphology "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0011069 abnormal brain ependyma motile cilium physiology "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

 MP:0030029 wide cranial sutures "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
Show

Allelic Composition: Igf2tm4.1Wrk/Igf2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000044933 Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*  / complex / reaction






 

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