ENSMUSG00000023828


Mus musculus

Features
Gene ID: ENSMUSG00000023828
  
Biological name :Slc22a3
  
Synonyms : Q9WTW5 / Slc22a3 / solute carrier family 22 (organic cation transporter), member 3
  
Possible biological names infered from orthology : O75751 / solute carrier family 22 member 3
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A1
Gene start: 12419972
Gene end: 12507704
  
Corresponding Affymetrix probe sets: 10447773 (MoGene1.0st)   1420444_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024595
NCBI entrez gene - 20519     See in Manteia.
MGI - MGI:1333817
RefSeq - NM_011395
RefSeq Peptide - NP_035525
swissprot - Q547K2
swissprot - Q9WTW5
Ensembl - ENSMUSG00000023828
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oct2ENSDARG00000058775Danio rerio
 SLC22A3ENSGALG00000020002Gallus gallus
 O75751ENSG00000146477Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70577 / Slc22a2 / Solute carrier family 22 member 2 / O15244*ENSMUSG0000004096650
O08966 / Slc22a1 / Solute carrier family 22 member 1 / O15245*ENSMUSG0000002382948
Q80UJ1 / Slc22a20 / Solute carrier family 22 member 20 ENSMUSG0000003745130
Q9WTN6 / Slc22a21 / solute carrier family 22 (organic cation transporter), member 21 / O76082* / SLC22A5* / solute carrier family 22 member 5*ENSMUSG0000006365230
Q9Z0E8 / Slc22a5 / solute carrier family 22 (organic cation transporter), member 5 / O76082* / solute carrier family 22 member 5*ENSMUSG0000001890029
Q9Z306 / Slc22a4 / Solute carrier family 22 member 4 / Q9H015*ENSMUSG0000002033429
Q8VC69 / Slc22a6 / Solute carrier family 22 member 6 / Q4U2R8*ENSMUSG0000002465029
O88909 / Slc22a8 / Solute carrier family 22 member 8 / Q8TCC7*ENSMUSG0000006379629
Slc22a12 / solute carrier family 22 member 12 / Q96S37*ENSMUSG0000006174228
Slc22a7 / solute carrier family 22 member 7 / Q9Y694*ENSMUSG0000006714428
Q6A4L0 / Slc22a13 / Solute carrier family 22 member 13 / Q9Y226*ENSMUSG0000007402828
Q8VCA0 / Slc22a19 / Solute carrier family 22 member 19 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000002475727
Q504N2 / Slc22a15 / Solute carrier family 22 member 15 / Q8IZD6*ENSMUSG0000003314727
Q8R0S9 / Slc22a22 / Mus musculus solute carrier family 22 (organic cation transporter), member 22 (Slc22a22), transcript variant 2, mRNA.ENSMUSG0000002236625
Slc22a30 / solute carrier family 22, member 30 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005256225
Slc22a26 / solute carrier family 22 (organic cation transporter), member 26 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005330325
Slc22a28 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006359025
Q76M72 / Slc22a27 / Solute carrier family 22 member 27 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006765625
Slc22a29 / solute carrier family 22. member 29 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000007504425
Q497L8 / Slc22a16 / solute carrier family 22 (organic cation transporter), member 16 / Q86VW1* / solute carrier family 22 member 16*ENSMUSG0000001983424


Protein motifs (from Interpro)
Interpro ID Name
 IPR004749  Organic cation transport protein/SVOP
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0015695 organic cation transport IEA
 biological_processGO:0015697 quaternary ammonium group transport ISO
 biological_processGO:0015711 organic anion transport IEA
 biological_processGO:0015844 monoamine transport IMP
 biological_processGO:0015872 dopamine transport IEA
 biological_processGO:0032098 regulation of appetite IMP
 biological_processGO:0051608 histamine transport IMP
 biological_processGO:0051615 histamine uptake IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1901998 toxin transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005329 dopamine transmembrane transporter activity IEA
 molecular_functionGO:0008514 organic anion transmembrane transporter activity IBA
 molecular_functionGO:0015101 organic cation transmembrane transporter activity IEA
 molecular_functionGO:0015651 quaternary ammonium group transmembrane transporter activity ISO
 molecular_functionGO:0019534 toxin transmembrane transporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Abacavir transmembrane transport
Organic cation transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc6a3tm1.1Jaja/Slc6a3tm1.1Jaja
Genetic Background: B6.129-Slc6a3tm1.1Jaja

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Slc6a3tm1.1Jaja/Slc6a3tm1.1Jaja
Genetic Background: B6.129-Slc6a3tm1.1Jaja

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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