ENSMUSG00000023829


Mus musculus

Features
Gene ID: ENSMUSG00000023829
  
Biological name :Slc22a1
  
Synonyms : O08966 / Slc22a1 / Solute carrier family 22 member 1
  
Possible biological names infered from orthology : O15245
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A1
Gene start: 12648874
Gene end: 12675838
  
Corresponding Affymetrix probe sets: 10447786 (MoGene1.0st)   1418118_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024596
NCBI entrez gene - 20517     See in Manteia.
MGI - MGI:108111
RefSeq - NM_009202
RefSeq Peptide - NP_033228
swissprot - O08966
Ensembl - ENSMUSG00000023829
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc22a2ENSDARG00000030530Danio rerio
 ENSGALG00000011615Gallus gallus
 ENSGALG00000011579Gallus gallus
 O15245ENSG00000175003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70577 / Slc22a2 / Solute carrier family 22 member 2 / O15244*ENSMUSG0000004096669
Q9WTW5 / Slc22a3 / solute carrier family 22 (organic cation transporter), member 3 / O75751* / solute carrier family 22 member 3*ENSMUSG0000002382847
Q9WTN6 / Slc22a21 / solute carrier family 22 (organic cation transporter), member 21 / O76082* / SLC22A5* / solute carrier family 22 member 5*ENSMUSG0000006365233
Q8VC69 / Slc22a6 / Solute carrier family 22 member 6 / Q4U2R8*ENSMUSG0000002465032
Q80UJ1 / Slc22a20 / Solute carrier family 22 member 20 ENSMUSG0000003745132
Q9Z0E8 / Slc22a5 / solute carrier family 22 (organic cation transporter), member 5 / O76082* / solute carrier family 22 member 5*ENSMUSG0000001890031
Q9Z306 / Slc22a4 / Solute carrier family 22 member 4 / Q9H015*ENSMUSG0000002033431
Q504N2 / Slc22a15 / Solute carrier family 22 member 15 / Q8IZD6*ENSMUSG0000003314729
O88909 / Slc22a8 / Solute carrier family 22 member 8 / Q8TCC7*ENSMUSG0000006379629
Q6A4L0 / Slc22a13 / Solute carrier family 22 member 13 / Q9Y226*ENSMUSG0000007402829
Slc22a12 / solute carrier family 22 member 12 / Q96S37*ENSMUSG0000006174228
Slc22a7 / solute carrier family 22 member 7 / Q9Y694*ENSMUSG0000006714428
Q497L8 / Slc22a16 / solute carrier family 22 (organic cation transporter), member 16 / Q86VW1* / solute carrier family 22 member 16*ENSMUSG0000001983427
Q8R0S9 / Slc22a22 / Mus musculus solute carrier family 22 (organic cation transporter), member 22 (Slc22a22), transcript variant 2, mRNA.ENSMUSG0000002236627
Q8VCA0 / Slc22a19 / Solute carrier family 22 member 19 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000002475727
Slc22a26 / solute carrier family 22 (organic cation transporter), member 26 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005330327
Slc22a30 / solute carrier family 22, member 30 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005256226
Slc22a28 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006359026
Slc22a29 / solute carrier family 22. member 29 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000007504425
Q76M72 / Slc22a27 / Solute carrier family 22 member 27 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006765624


Protein motifs (from Interpro)
Interpro ID Name
 IPR004749  Organic cation transport protein/SVOP
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IDA
 biological_processGO:0006836 neurotransmitter transport IBA
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0015695 organic cation transport IEA
 biological_processGO:0015697 quaternary ammonium group transport IEA
 biological_processGO:0015711 organic anion transport IEA
 biological_processGO:0015844 monoamine transport IEA
 biological_processGO:0015872 dopamine transport IEA
 biological_processGO:0015874 norepinephrine transport IEA
 biological_processGO:0048241 epinephrine transport IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0072488 ammonium transmembrane transport IEA
 biological_processGO:1901374 acetate ester transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005277 acetylcholine transmembrane transporter activity IEA
 molecular_functionGO:0005329 dopamine transmembrane transporter activity IEA
 molecular_functionGO:0005333 norepinephrine transmembrane transporter activity IEA
 molecular_functionGO:0008504 monoamine transmembrane transporter activity IEA
 molecular_functionGO:0008513 secondary active organic cation transmembrane transporter activity IEA
 molecular_functionGO:0008514 organic anion transmembrane transporter activity IBA
 molecular_functionGO:0015101 organic cation transmembrane transporter activity IEA
 molecular_functionGO:0015651 quaternary ammonium group transmembrane transporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter clearance
Norepinephrine Neurotransmitter Release Cycle
Abacavir transmembrane transport
Na+/Cl- dependent neurotransmitter transporters
Organic cation transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0002139 abnormal liver/biliary system physiology "altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0006273 abnormal renal organic cation excretion "anomaly in the ability of the kidneys to elimiate organic bases (represented by the prototypical substrate tetraethylammonium (TEA))" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Slc22a1tm1Ahs/Slc22a1tm1Ahs
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc22a1tm1Ahs/Slc22a1tm1Ahs
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Slc22a1tm1Kmgi/Slc22a1tm1Kmgi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0013277 abnormal fasted circulating glucose level "any anomaly in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Slc22a1tm1Kmgi/Slc22a1tm1Kmgi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0020101 abnormal hepatic glucose production "an anomaly in the production of glucose in the liver" [GOC:NV]
Show

Allelic Composition: Slc22a1tm1Kmgi/Slc22a1tm1Kmgi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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