ENSMUSG00000063652


Mus musculus
transportSlc22a21transmembranetransportercationmembraneactivityorganiccarnitinecomponentmajorfacilitatorsugarsuperfamilyionanionperoxisomalintegralbindingproteinsvoptransporter-likeconservedsitedomainmfsmetabolicprocessperoxisomeplasmaintrinsic

Features
Gene ID: ENSMUSG00000063652
  
Biological name :Slc22a21
  
Synonyms : Q9WTN6 / Slc22a21 / solute carrier family 22 (organic cation transporter), member 21
  
Possible biological names infered from orthology : O76082 / SLC22A5 / solute carrier family 22 member 5
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 53949965
Gene end: 53980332
  
Corresponding Affymetrix probe sets: 10385883 (MoGene1.0st)   1449215_at (Mouse Genome 430 2.0 Array)   1450395_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123180
Ensembl peptide - ENSMUSP00000075814
Ensembl peptide - ENSMUSP00000114966
NCBI entrez gene - 56517     See in Manteia.
MGI - MGI:1929481
RefSeq - XM_011249156
RefSeq - XM_006533805
RefSeq - XM_006533807
RefSeq - XM_006533808
RefSeq - XM_006533809
RefSeq - XM_011249155
RefSeq - NM_019723
RefSeq - XM_006533804
RefSeq Peptide - NP_062697
swissprot - F6YI98
swissprot - D6RDB6
swissprot - A2RSK7
swissprot - Q9WTN6
Ensembl - ENSMUSG00000063652
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc22a21ENSDARG00000094112Danio rerio
 slc22a4ENSDARG00000005335Danio rerio
 slc22a5ENSDARG00000101021Danio rerio
 SLC22A5ENSGALG00000036920Gallus gallus
 O76082ENSG00000197375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z0E8 / Slc22a5 / solute carrier family 22 (organic cation transporter), member 5 / O76082* / solute carrier family 22 member 5*ENSMUSG0000001890083
Q9Z306 / Slc22a4 / Solute carrier family 22 member 4 / Q9H015*ENSMUSG0000002033469
O08966 / Slc22a1 / Solute carrier family 22 member 1 / O15245*ENSMUSG0000002382932
O70577 / Slc22a2 / Solute carrier family 22 member 2 / O15244*ENSMUSG0000004096631
Slc22a7 / solute carrier family 22 member 7 / Q9Y694*ENSMUSG0000006714431
Q9WTW5 / Slc22a3 / solute carrier family 22 (organic cation transporter), member 3 / O75751* / solute carrier family 22 member 3*ENSMUSG0000002382830
Q80UJ1 / Slc22a20 / Solute carrier family 22 member 20 ENSMUSG0000003745130
Q8R0S9 / Slc22a22 / Mus musculus solute carrier family 22 (organic cation transporter), member 22 (Slc22a22), transcript variant 2, mRNA.ENSMUSG0000002236629
Q8VC69 / Slc22a6 / Solute carrier family 22 member 6 / Q4U2R8*ENSMUSG0000002465028
Q504N2 / Slc22a15 / Solute carrier family 22 member 15 / Q8IZD6*ENSMUSG0000003314728
O88909 / Slc22a8 / Solute carrier family 22 member 8 / Q8TCC7*ENSMUSG0000006379628
Q6A4L0 / Slc22a13 / Solute carrier family 22 member 13 / Q9Y226*ENSMUSG0000007402828
Slc22a30 / solute carrier family 22, member 30 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005256227
Slc22a26 / solute carrier family 22 (organic cation transporter), member 26 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000005330327
Slc22a12 / solute carrier family 22 member 12 / Q96S37*ENSMUSG0000006174227
Slc22a28 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006359027
Q497L8 / Slc22a16 / solute carrier family 22 (organic cation transporter), member 16 / Q86VW1* / solute carrier family 22 member 16*ENSMUSG0000001983426
Q8VCA0 / Slc22a19 / Solute carrier family 22 member 19 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000002475726
Q76M72 / Slc22a27 / Solute carrier family 22 member 27 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000006765626
Slc22a29 / solute carrier family 22. member 29 / Q8IVM8* / Q6T423* / SLC22A9* / SLC22A25* / solute carrier family 22 member 9* / solute carrier family 22 member 25*ENSMUSG0000007504426


Protein motifs (from Interpro)
Interpro ID Name
 IPR004749  Organic cation transport protein/SVOP
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
establishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processorganic substance metabolic processestablishment of localizationestablishment of localizationnitrogen compound metabolic processnitrogen compound metabolic processcellular metabolic processcellular metabolic processorganic substance metabolic processorganic substance metabolic process
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcarbohydrate derivative bindingdrug bindingtransmembrane transporter activityorganic cyclic compoorganic cyclic compound bindingheterocyclic compounheterocyclic compound bindingsmall molecule bindismall molecule bindingion bindingion bindingcarbohydrate derivatcarbohydrate derivative bindingdrug bindingdrug bindingtransmembrane transptransmembrane transporter activity
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0009437 carnitine metabolic process IBA
 biological_processGO:0015711 organic anion transport IEA
 biological_processGO:0015879 carnitine transport IDA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1902603 carnitine transmembrane transport IEA
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031231 intrinsic component of peroxisomal membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008514 organic anion transmembrane transporter activity IBA
 molecular_functionGO:0015226 carnitine transmembrane transporter activity IDA
 molecular_functionGO:0015491 cation:cation antiporter activity IBA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Import of palmitoyl-CoA into the mitochondrial matrix
Organic cation transport


Phenotype (from MGI, Zfin or HPO)
reproductive system phenotypereproductive system phenotypereproductive system phenotypereproductive system phenotypereproductive system phenotypereproductive system phenotypereproductive system phenotypereproductive system phenotypereproductive system phenotypereproductive system phenotypereproductive system phenotypereproductive system phenotype
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009199 abnormal external male genitalia morphology "any structural anomaly of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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