ENSMUSG00000024193


Mus musculus

Features
Gene ID: ENSMUSG00000024193
  
Biological name :Phf1
  
Synonyms : PHD finger protein 1 / Phf1 / Q9Z1B8
  
Possible biological names infered from orthology : O43189
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 26933127
Gene end: 26937890
  
Corresponding Affymetrix probe sets: 10443063 (MoGene1.0st)   1416542_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073402
NCBI entrez gene - 21652     See in Manteia.
MGI - MGI:98647
RefSeq - NM_009343
RefSeq - NM_001302397
RefSeq Peptide - NP_001289326
RefSeq Peptide - NP_033369
swissprot - Q9Z1B8
Ensembl - ENSMUSG00000024193
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phf1ENSDARG00000057439Danio rerio
 PHF1ENSG00000112511Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phf19 / Q9CXG9 / PHD finger protein 19 / Q5T6S3*ENSMUSG0000002687338
Mtf2 / Q02395 / Metal-response element-binding transcription factor 2 / Q9Y483*ENSMUSG0000002926738


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR025894  Polycomb-like MTF2 factor 2, C-terminal domain
 IPR031202  PHD finger protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0031060 regulation of histone methylation IEA
 biological_processGO:0061086 negative regulation of histone H3-K27 methylation IEA
 biological_processGO:0061087 positive regulation of histone H3-K27 methylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex






 

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