ENSMUSG00000057236


Mus musculus

Features
Gene ID: ENSMUSG00000057236
  
Biological name :Rbbp4
  
Synonyms : Histone-binding protein RBBP4 / Q60972 / Rbbp4
  
Possible biological names infered from orthology : Q09028 / RB binding protein 4, chromatin remodeling factor
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 129307100
Gene end: 129335370
  
Corresponding Affymetrix probe sets: 10516576 (MoGene1.0st)   1434892_x_at (Mouse Genome 430 2.0 Array)   1454791_a_at (Mouse Genome 430 2.0 Array)   1454875_a_at (Mouse Genome 430 2.0 Array)   1456260_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116517
Ensembl peptide - ENSMUSP00000099658
NCBI entrez gene - 19646     See in Manteia.
MGI - MGI:1194912
RefSeq - NM_009030
RefSeq Peptide - NP_033056
swissprot - A8Y5E8
swissprot - Q60972
Ensembl - ENSMUSG00000057236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbbp4ENSDARG00000029058Danio rerio
 RBBP4ENSGALG00000003522Gallus gallus
 RBBP4ENSG00000162521Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*ENSMUSG0000003135389


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR022052  Histone-binding protein RBBP4, N-terminal
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006335 DNA replication-dependent nucleosome assembly IEA
 biological_processGO:0006336 DNA replication-independent nucleosome assembly IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0031497 chromatin assembly IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016581 NuRD complex IEA
 cellular_componentGO:0016589 NURF complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0033186 CAF-1 complex IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
Deposition of new CENPA-containing nucleosomes at the centromere
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004099 Dnmt1 / P13864 / DNA (cytosine-5)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / complex / reaction
 ENSMUSG00000020661 Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*  / complex / reaction
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / complex / reaction
 ENSMUSG00000024240 Epc1 / Q8C9X6 / Enhancer of polycomb homolog 1 / Q9H2F5*  / complex / reaction
 ENSMUSG00000026873 Phf19 / Q9CXG9 / PHD finger protein 19 / Q5T6S3*  / complex
 ENSMUSG00000030232 Aebp2 / Q9Z248 / Zinc finger protein AEBP2 / Q6ZN18* / AE binding protein 2*  / complex
 ENSMUSG00000038518 Jarid2 / Q62315 / Protein Jumonji / Q92833* / jumonji and AT-rich interaction domain containing 2*  / complex
 ENSMUSG00000027478 Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex
 ENSMUSG00000029267 Mtf2 / Q02395 / Metal-response element-binding transcription factor 2 / Q9Y483*  / complex
 ENSMUSG00000024193 Phf1 / Q9Z1B8 / PHD finger protein 1 / O43189*  / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction






 

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