ENSMUSG00000024987


Mus musculus
developmentCyp26a1hypoplasiapactivitytailcytochromeprocessretinoicacidbindingganglionlethalityoxidoreductaseincorporationoxygenincreasedneuralrhombomeretrigeminalnervetransformationmetabolicionactingpaireddonorsreductionmolecularonecardiac

Features
Gene ID: ENSMUSG00000024987
  
Biological name :Cyp26a1
  
Synonyms : Cyp26a1 / cytochrome P450 family 26 subfamily A member 1
  
Possible biological names infered from orthology : O43174
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C2
Gene start: 37697808
Gene end: 37701528
  
Corresponding Affymetrix probe sets: 10462853 (MoGene1.0st)   1419430_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025946
NCBI entrez gene - 13082     See in Manteia.
MGI - MGI:1096359
RefSeq - NM_007811
RefSeq - XM_017318053
RefSeq Peptide - NP_031837
swissprot - A0A0R4J061
Ensembl - ENSMUSG00000024987
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp26a1ENSDARG00000033999Danio rerio
 CYP26A1ENSGALG00000033695Gallus gallus
 O43174ENSG00000095596Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp26c1 / cytochrome P450, family 26, subfamily c, polypeptide 1 / Q6V0L0* / cytochrome P450 family 26 subfamily C member 1*ENSMUSG0000006243243
Q811W2 / Cyp26b1 / Cytochrome P450 26B1 / Q9NR63* / cytochrome P450 family 26 subfamily B member 1*ENSMUSG0000006341543
Cyp51 / Q8K0C4 / Lanosterol 14-alpha demethylase / Q16850* / CYP51A1* / cytochrome P450 family 51 subfamily A member 1*ENSMUSG0000000146723


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
response to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processsmall molecule metabolic processregulation of biological qualityorganic substance metabolic processoxidation-reduction processresponse to cheresponse to chemicalcellular metabocellular metabolic processcellular responcellular response to stimuluscatabolic procecatabolic processprimary metabolprimary metabolic processsmall molecule small molecule metabolic processregulation of bregulation of biological qualityorganic substanorganic substance metabolic processoxidation-reducoxidation-reduction process
lipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindingion bindingsmall molecule bindingoxidoreductase activityorganic cyclic compound bindingheterocyclic compound bindingcofactor bindinglipid bindinglipid bindingion bindingion bindingsmall molecule bindismall molecule bindingoxidoreductase activoxidoreductase activityorganic cyclic compoorganic cyclic compound bindingheterocyclic compounheterocyclic compound bindingcofactor bindingcofactor binding
TypeGO IDTermEv.Code
 biological_processGO:0006805 xenobiotic metabolic process IEA
 biological_processGO:0034653 retinoic acid catabolic process IEA
 biological_processGO:0042573 retinoic acid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0001972 retinoic acid binding IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008401 retinoic acid 4-hydroxylase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamins
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
skeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phenotypecardiovascular system phenotypegrowth/size phenotypelimbs/digits/tail phenotypenervous system phenotypeembryogenesis phenotyperenal/urinary system phenotypecellular phenotypedigestive/alimentary phenotypecraniofacial phenotypereproductive system phenotypemortality/agingskeleton phskeleton phenotypecardiovascucardiovascular system phenotypegrowth/sizegrowth/size phenotypelimbs/digitlimbs/digits/tail phenotypenervous sysnervous system phenotypeembryogenesembryogenesis phenotyperenal/urinarenal/urinary system phenotypecellular phcellular phenotypedigestive/adigestive/alimentary phenotypecraniofaciacraniofacial phenotypereproductivreproductive system phenotypemortality/amortality/aging
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Artm2(AR)Dmr/Y,Tg(TRAMP)8247Ng/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Artm2(AR)Dmr/Y,Tg(TRAMP)8247Ng/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Artm2(AR)Dmr/Y,Tg(TRAMP)8247Ng/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000933 abnormal rhombomere morphology "malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001082 abnormal geniculate ganglion morphology "malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Artm2(AR)Dmr/Y,Tg(TRAMP)8247Ng/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003445 sirenomelia "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0003605 fused kidneys 
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0003637 cochlear ganglion hypoplasia "reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003942 abnormal urinary system development 
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006302 abnormal ectomesenchyme morphology "abnormality in the mesenchymal cells derived from neural crest cells that contribute to development of the hard and soft tissue in the head and neck, including the branchial arches." [J:119939, mnk:Michelle Knowlton_MGI Curator]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008487 abnormal mesonephros morphology "any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop" [MESH:A16.254.500]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008786 abnormal hindgut morphology "any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009798 abnormal ophthalmic nerve morphology "any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009799 abnormal maxillary nerve morphology "any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0010116 abnormal primitive urogenital sinus morphology "any structural anomaly of the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Scn8a5J/Scn8a5J
Genetic Background: C57BL/6J-Scn8a5J/J

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011361 pelvic kidney "an ectopic kidney located outside the renal fossa and within the pelvic cavity; pelvic kidneys may also, on occasion, occur as fused midline horseshoe kidneys" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0011772 genital tubercle hypoplasia "underdevelopment or reduced size of the embryonic anlage of the external genitalia, usually due to a reduced number of cells" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0012090 midbrain hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012265 increased hindbrain size "greater than average size of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012798 increased rhombomere 4 size "increased size of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0012818 rhombomere transformation "homeotic transformation of a specific rhombomere to adopt the fate of another" [MGI:csmith]
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Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0013180 truncated tail bud "shortened tail bud that terminates in a blunt end (instead of a tapered end)" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013183 absent trigeminal ganglion "absence of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013267 first pharyngeal arch hypoplasia "underdevelopment or reduced size of the first pharyngeal arch, usually due to reduced cell number" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013268 second pharyngeal arch hypoplasia "underdevelopment or reduced size of the second pharyngeal arch, usually due to reduced cell number" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032291 Crabp1 / P62965 / Cellular retinoic acid-binding protein 1 / P29762*  / reaction






 

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