ENSMUSG00000062432


Mus musculus

Features
Gene ID: ENSMUSG00000062432
  
Biological name :Cyp26c1
  
Synonyms : Cyp26c1 / cytochrome P450, family 26, subfamily c, polypeptide 1
  
Possible biological names infered from orthology : cytochrome P450 family 26 subfamily C member 1 / Q6V0L0
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C2
Gene start: 37685581
Gene end: 37693398
  
Corresponding Affymetrix probe sets: 10462846 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000073105
NCBI entrez gene - 546726     See in Manteia.
MGI - MGI:2679699
RefSeq - NM_001105201
RefSeq - XM_017318259
RefSeq Peptide - NP_001098671
swissprot - B2RXA7
Ensembl - ENSMUSG00000062432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp26c1ENSDARG00000056029Danio rerio
 CYP26C1ENSGALG00000043213Gallus gallus
 Q6V0L0ENSG00000187553Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q811W2 / Cyp26b1 / Cytochrome P450 26B1 / Q9NR63* / cytochrome P450 family 26 subfamily B member 1*ENSMUSG0000006341552
Cyp26a1 / cytochrome P450 family 26 subfamily A member 1 / O43174*ENSMUSG0000002498742
Cyp51 / Q8K0C4 / Lanosterol 14-alpha demethylase / Q16850* / CYP51A1* / cytochrome P450 family 51 subfamily A member 1*ENSMUSG0000000146720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007417 central nervous system development IGI
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0014032 neural crest cell development IGI
 biological_processGO:0016125 sterol metabolic process IBA
 biological_processGO:0034653 retinoic acid catabolic process IEA
 biological_processGO:0048284 organelle fusion IGI
 biological_processGO:0055114 oxidation-reduction process ISO
 molecular_functionGO:0001972 retinoic acid binding IEA
 molecular_functionGO:0004497 monooxygenase activity IBA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008401 retinoic acid 4-hydroxylase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamins
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000933 abnormal rhombomere morphology "malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001082 abnormal geniculate ganglion morphology "malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad51ctm1Sks/Rad51ctm1.1Sks
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003637 cochlear ganglion hypoplasia "reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006302 abnormal ectomesenchyme morphology "abnormality in the mesenchymal cells derived from neural crest cells that contribute to development of the hard and soft tissue in the head and neck, including the branchial arches." [J:119939, mnk:Michelle Knowlton_MGI Curator]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012090 midbrain hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012265 increased hindbrain size "greater than average size of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013180 truncated tail bud "shortened tail bud that terminates in a blunt end (instead of a tapered end)" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013183 absent trigeminal ganglion "absence of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013267 first pharyngeal arch hypoplasia "underdevelopment or reduced size of the first pharyngeal arch, usually due to reduced cell number" [MGI:anna]
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Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013268 second pharyngeal arch hypoplasia "underdevelopment or reduced size of the second pharyngeal arch, usually due to reduced cell number" [MGI:anna]
Show

Allelic Composition: Cyp26a1tm1.1Hmd/Cyp26a1tm1.1Hmd,Cyp26c1tm1.1Keya/Cyp26c1tm1.1Keya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032291 Crabp1 / P62965 / Cellular retinoic acid-binding protein 1 / P29762*  / reaction






 

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