ENSMUSG00000063415


Mus musculus

Features
Gene ID: ENSMUSG00000063415
  
Biological name :Cyp26b1
  
Synonyms : Cyp26b1 / Cytochrome P450 26B1 / Q811W2
  
Possible biological names infered from orthology : cytochrome P450 family 26 subfamily B member 1 / Q9NR63
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 84571414
Gene end: 84593908
  
Corresponding Affymetrix probe sets: 10545771 (MoGene1.0st)   1460011_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144998
Ensembl peptide - ENSMUSP00000145092
Ensembl peptide - ENSMUSP00000076886
Ensembl peptide - ENSMUSP00000128391
Ensembl peptide - ENSMUSP00000144836
NCBI entrez gene - 232174     See in Manteia.
MGI - MGI:2176159
RefSeq - XM_006505972
RefSeq - XM_011241300
RefSeq - NM_001177713
RefSeq - NM_175475
RefSeq Peptide - NP_001171184
RefSeq Peptide - NP_780684
swissprot - Q811W2
swissprot - A0A0N4SV88
swissprot - A0A0N4SUV4
Ensembl - ENSMUSG00000063415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp26b1ENSDARG00000077121Danio rerio
 CYP26B1ENSGALG00000016102Gallus gallus
 Q9NR63ENSG00000003137Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp26c1 / cytochrome P450, family 26, subfamily c, polypeptide 1 / Q6V0L0* / cytochrome P450 family 26 subfamily C member 1*ENSMUSG0000006243253
Cyp26a1 / cytochrome P450 family 26 subfamily A member 1 / O43174*ENSMUSG0000002498742
Cyp51 / Q8K0C4 / Lanosterol 14-alpha demethylase / Q16850* / CYP51A1* / cytochrome P450 family 51 subfamily A member 1*ENSMUSG0000000146720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001709 cell fate determination IMP
 biological_processGO:0001768 establishment of T cell polarity IMP
 biological_processGO:0006805 xenobiotic metabolic process ISO
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009954 proximal/distal pattern formation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016125 sterol metabolic process IBA
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0034653 retinoic acid catabolic process ISO
 biological_processGO:0042573 retinoic acid metabolic process IC
 biological_processGO:0043587 tongue morphogenesis IMP
 biological_processGO:0045580 regulation of T cell differentiation IMP
 biological_processGO:0048384 retinoic acid receptor signaling pathway IMP
 biological_processGO:0048385 regulation of retinoic acid receptor signaling pathway IMP
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060349 bone morphogenesis ISO
 biological_processGO:0061436 establishment of skin barrier IMP
 biological_processGO:0070268 cornification IMP
 biological_processGO:0071300 cellular response to retinoic acid IEP
 biological_processGO:2001037 positive regulation of tongue muscle cell differentiation IMP
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0001972 retinoic acid binding ISO
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008401 retinoic acid 4-hydroxylase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamins
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Cyp26b1tm1.1Ptk/Cyp26b1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0001705 abnormal proximal-distal axis patterning "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cyp26b1tm1.1Ptk/Cyp26b1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cyp26b1tm1.1Ptk/Cyp26b1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp26b1tm1.1Ptk/Cyp26b1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Cyp26b1tm1Dcp/Cyp26b1tm1Dcp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp26b1tm1.1Ptk/Cyp26b1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas

 MP:0009594 abnormal corneocyte envelope morphology "any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009603 absent keratohyalin granules "absence of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010197 abnormal lymphatic vessel endothelial cell morphology "any structural anomaly of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cyp26b1tm1.1Ptk/Cyp26b1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Cyp26b1tm1Dcp/Cyp26b1tm1Dcp
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0014106 delayed chondrocyte differentiation "delay in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032291 Crabp1 / P62965 / Cellular retinoic acid-binding protein 1 / P29762*  / reaction






 

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