ENSMUSG00000025176


Mus musculus

Features
Gene ID: ENSMUSG00000025176
  
Biological name :Hoga1
  
Synonyms : 4-hydroxy-2-oxoglutarate aldolase, mitochondrial / Hoga1 / Q9DCU9
  
Possible biological names infered from orthology : 4-hydroxy-2-oxoglutarate aldolase 1 / Q86XE5
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 42045610
Gene end: 42070953
  
Corresponding Affymetrix probe sets: 10463200 (MoGene1.0st)   10463209 (MoGene1.0st)   1450098_at (Mouse Genome 430 2.0 Array)   1452802_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126037
Ensembl peptide - ENSMUSP00000080414
NCBI entrez gene - 67432     See in Manteia.
MGI - MGI:1914682
RefSeq - NM_026152
RefSeq Peptide - NP_080428
swissprot - E9Q1R2
swissprot - Q9DCU9
Ensembl - ENSMUSG00000025176
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoga1ENSDARG00000018944Danio rerio
 HOGA1ENSGALG00000006134Gallus gallus
 HOGA1ENSG00000241935Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npl / Q9DCJ9 / N-acetylneuraminate lyase / Q9BXD5* / N-acetylneuraminate pyruvate lyase*ENSMUSG0000004268423


Protein motifs (from Interpro)
Interpro ID Name
 IPR002220  DapA-like
 IPR013785  Aldolase-type TIM barrel
 IPR020625  Schiff base-forming aldolase, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009436 glyoxylate catabolic process IEA
 biological_processGO:0019470 4-hydroxyproline catabolic process IEA
 biological_processGO:0033609 oxalate metabolic process IEA
 biological_processGO:0042866 pyruvate biosynthetic process IEA
 biological_processGO:0046487 glyoxylate metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008700 4-hydroxy-2-oxoglutarate aldolase activity ISO
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mir196a-1tm1.1Wtsi/Mir196a-1tm1.1Wtsi,Mir196a-2tm1.1Wtsi/Mir196a-2tm1.1Wtsi,Mir196btm1.1Wtsi/Mir196btm1.1Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mir196a-1tm1.1Wtsi/Mir196a-1tm1.1Wtsi,Mir196a-2tm1.1Wtsi/Mir196a-2tm1.1Wtsi,Mir196btm1.1Wtsi/Mir196btm1.1Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir196a-1tm1.1Wtsi/Mir196a-1tm1.1Wtsi,Mir196a-2tm1.1Wtsi/Mir196a-2tm1.1Wtsi,Mir196btm1.1Wtsi/Mir196btm1.1Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025176 Hoga1 / Q9DCU9 / 4-hydroxy-2-oxoglutarate aldolase, mitochondrial / Q86XE5* / 4-hydroxy-2-oxoglutarate aldolase 1*  / complex






 

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