Manteia - Molecule gene

ENSMUSG00000025278

Mus musculus

Features

Gene ID:	ENSMUSG00000025278

Biological name :	Flnb

Synonyms :	Filamin-B / Flnb / Q80X90

Possible biological names infered from orthology :	O75369

Species:	Mus musculus

Chr. number:	14
Strand:	1
Band:	A1
Gene start:	7817957
Gene end:	7951588

Corresponding Affymetrix probe sets:	10412562 (MoGene1.0st) 1426750_at (Mouse Genome 430 2.0 Array) 1442107_at (Mouse Genome 430 2.0 Array) 1458226_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000052020 NCBI entrez gene - 286940 See in Manteia. MGI - MGI:2446089 RefSeq - XM_006518050 RefSeq - NM_001081427 RefSeq - NM_134080 RefSeq Peptide - NP_598841 RefSeq Peptide - NP_001074896 swissprot - Q80X90 Ensembl - ENSMUSG00000025278

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
FP325130.1	ENSDARG00000112527	Danio rerio
FLNB	ENSGALG00000005678	Gallus gallus
FLNB	ENSG00000136068	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Flnc / Q8VHX6 / Filamin-C / Q14315*	ENSMUSG00000068699	70
Flna / Q8BTM8 / Filamin-A / P21333*	ENSMUSG00000031328	69
Syne2 / Q6ZWQ0 / spectrin repeat containing, nuclear envelope 2 / Q8WXH0* / spectrin repeat containing nuclear envelope protein 2*	ENSMUSG00000063450	16
Clmn / Q8C5W0 / Calmin / Q96JQ2*	ENSMUSG00000021097	7
Syne1 / Q6ZWR6 / Mus musculus spectrin repeat containing, nuclear envelope 1 (Syne1), transcript variant 5, mRNA. / Q8NF91* / spectrin repeat containing nuclear envelope protein 1*	ENSMUSG00000096054	6

Protein motifs (from Interpro)

Interpro ID	Name
IPR001298	Filamin/ABP280 repeat
IPR001589	Actinin-type actin-binding domain, conserved site
IPR001715	Calponin homology domain
IPR013783	Immunoglobulin-like fold
IPR014756	Immunoglobulin E-set
IPR017868	Filamin/ABP280 repeat-like
IPR029874	Filamin-B
IPR036872	CH domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003334	keratinocyte development	IMP
biological_process	GO:0003382	epithelial cell morphogenesis	IMP
biological_process	GO:0007519	skeletal muscle tissue development	IDA
biological_process	GO:0030036	actin cytoskeleton organization	IMP
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0071346	cellular response to interferon-gamma	IDA
cellular_component	GO:0001725	stress fiber	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005903	brush border	IDA
cellular_component	GO:0005925	focal adhesion	IDA
cellular_component	GO:0005938	cell cortex	IEA
cellular_component	GO:0030018	Z disc	IEA
cellular_component	GO:0031012	extracellular matrix	ISO
cellular_component	GO:0043005	neuron projection	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0045335	phagocytic vesicle	IDA
molecular_function	GO:0003779	actin binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0045296	cadherin binding	IEA

Pathways (from Reactome)

Pathway description

ISG15 antiviral mechanism

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000069	kyphoscoliosis	"kyphosis combined with scoliosis" [MGI:CML, J:66943]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0000074	abnormal neurocranium morphology	"malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000109	abnormal parietal bone morphology	"malformed curved bone forming part of the vault of the cranium" [J:17489]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0000154	rib fusion	"appearance of one or more ribs as a single structure" [J:62022, J:62023]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Flnb^{Gt(RRF239)Byg}/Flnb^{Gt(RRF239)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^skm2/Flnb^skm2 Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000161	scoliosis	"lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]	Show Allelic Composition: Flnb^{Gt(RRF239)Byg}/Flnb^{Gt(RRF239)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^skm2/Flnb^skm2 Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000162	lordosis	"anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]	Show Allelic Composition: Flnb^skm2/Flnb^skm2 Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000166	abnormal chondrocyte morphology	"anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000260	abnormal angiogenesis	"aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000552	abnormal radius morphology	"malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Flnb^{Gt(RRF239)Byg}/Flnb^{Gt(RRF239)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001255	decreased body height	"decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]	Show Allelic Composition: Hmox1^tm1.1Hes/Hmox1^tm1.1Hes,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N Allelic Composition: Flnb^{Gt(RRF239)Byg}/Flnb^{Gt(RRF239)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Cftr^tm1Unc/Cftr⁺ Genetic Background: involves: BALB/cJ * C57BL/6J Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Hmox1^tm1.1Hes/Hmox1^tm1.1Hes,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
MP:0001429	dehydration	"excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]	Show Allelic Composition: Hmox1^tm1.1Hes/Hmox1^tm1.1Hes,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
MP:0001504	abnormal posture	"atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: IL-23RIl23r^tm1.1Ngh/IL-23RIl23r^tm1.1Ngh,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002115	abnormal skeleton extremities morphology	"abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: IL-23RIl23r^tm1.1Ngh/IL-23RIl23r^tm1.1Ngh,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002543	brachyphalangia	"abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003345	decreased number of ribs	"fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Flnb^skm2/Flnb^skm2 Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J
MP:0003408	increased width of hypertrophic chondrocyte zone	"increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003409	decreased width of hypertrophic chondrocyte zone	"decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003410	abnormal artery development	"anomaly in the process of forming the blood vessels that carry blood away from the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003420	delayed intramembranous bone ossification	"late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003566	abnormal cell adhesion	"altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003662	abnormal proliferative zone	"germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0004322	abnormal sternebra morphology	"any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg,Runx2^tm1Mjo/Runx2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004355	short radius	"reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0004441	small occipital bone	"reduced size of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg,Runx2^tm1Mjo/Runx2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004609	vertebral fusion	"the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N Allelic Composition: Flnb^{Gt(RRF239)Byg}/Flnb^{Gt(RRF239)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0004620	cervical vertebral fusion	"the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0004623	thoracic vertebral fusion	"the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^skm2/Flnb^skm2 Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J
MP:0004624	abnormal thoracic cage	"any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^skm2/Flnb^skm2 Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0004674	thin ribs	"a more slender appearance of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0004683	absent intervertebral disk	"absence of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0004703	abnormal vertebral column	"any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0004950	abnormal brain vasculature	"any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0005108	abnormal ulna morphology	"malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Flnb^{Gt(RRF239)Byg}/Flnb^{Gt(RRF239)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005269	abnormal occipital bone morphology	"anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005274	abnormal viscerocranium morphology	"anomalous structure or formation of the part of the skull that comprises the facial bones " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005353	abnormal patella morphology	"anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005426	tachypnea	"rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Flnb^skm2/Flnb^skm2 Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0006322	abnormal perichondrium morphology	"any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", J:117033, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0006396	decreased long bone epiphyseal plate size	"reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0006429	abnormal hyaline cartilage morphology	"any structural anomaly of the bluish-white, glassy, translucent nonvascular, resilient, flexible connective tissue; found primarily in articular cartilage, costal cartilages, the nasal septum, the larynx, and the trachea" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0008069	abnormal joint mobility	"anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0008155	decreased diameter of radius	"reduced width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0008157	decreased diameter of ulna	"reduced width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008915	fused carpal bones	"anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Flnb^{Gt(RRF239)Byg}/Flnb^{Gt(RRF239)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009780	abnormal chondrocyte physiology	"any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0010103	small thoracic cage	"reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Flnb^{Gt(RRF239)Byg}/Flnb^{Gt(RRF239)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Flnb^{Gt(RRF239)Byg}/Flnb^{Gt(RRF239)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Flnb^skm2/Flnb^skm2 Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0011708	decreased fibroblast cell migration	"reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0013258	abnormal extracellular matrix morphology	"any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell " [GO:0031012]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0020040	decreased bone ossification	"decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0020137	decreased bone mineralization	"decrease in the rate at which minerals are deposited into bone" []	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0020487	abnormal middle cerebral artery morphology	"any structural anomaly of the major paired arteries that arise from the internal carotid artery and supply blood to a portion of the frontal lobe and the lateral surface of the temporal and parietal lobes" [http://www.strokecenter.org/professionals/brain-anatomy/blood-vessels-of-the-brain/, https://radiopaedia.org/articles/middle-cerebral-artery]	Show Allelic Composition: Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp,Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
MP:0030029	wide cranial sutures	"an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]	Show Allelic Composition: Flnb^Gt(XD076)Byg/Flnb^Gt(XD076)Byg,Runx2^tm1Mjo/Runx2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025234	Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*	/ reaction
ENSMUSG00000035692	Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*	/ complex / reaction
ENSMUSG00000027078	Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*	/ reaction

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