ENSMUSG00000025234


Mus musculus

Features
Gene ID: ENSMUSG00000025234
  
Biological name :Arih1
  
Synonyms : Arih1 / E3 ubiquitin-protein ligase ARIH1 / Q9Z1K5
  
Possible biological names infered from orthology : ariadne RBR E3 ubiquitin protein ligase 1 / Q9Y4X5
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 59388258
Gene end: 59486618
  
Corresponding Affymetrix probe sets: 10594161 (MoGene1.0st)   1427188_at (Mouse Genome 430 2.0 Array)   1427189_at (Mouse Genome 430 2.0 Array)   1436498_at (Mouse Genome 430 2.0 Array)   1441022_at (Mouse Genome 430 2.0 Array)   1459397_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026264
Ensembl peptide - ENSMUSP00000126531
Ensembl peptide - ENSMUSP00000131140
Ensembl peptide - ENSMUSP00000131516
NCBI entrez gene - 23806     See in Manteia.
MGI - MGI:1344363
RefSeq - XM_011242739
RefSeq - NM_019927
RefSeq - XM_006511140
RefSeq - XM_006511141
RefSeq Peptide - NP_064311
swissprot - Q9Z1K5
swissprot - H9KV21
swissprot - H7BWY7
swissprot - F7A7T5
Ensembl - ENSMUSG00000025234
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arih1ENSDARG00000003616Danio rerio
 arih1lENSDARG00000036870Danio rerio
 ARIH1ENSGALG00000001901Gallus gallus
 ARIH1ENSG00000166233Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arih2 / Q9Z1K6 / Mus musculus ariadne RBR E3 ubiquitin protein ligase 2 (Arih2), transcript variant 2, mRNA. / O95376* / ariadne RBR E3 ubiquitin protein ligase 2*ENSMUSG0000006414530
Ankib1 / Q6ZPS6 / Ankyrin repeat and IBR domain-containing protein 1 / Q9P2G1* / ankyrin repeat and IBR domain containing 1*ENSMUSG0000004035128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR002867  IBR domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR031127  E3 ubiquitin ligase RBR family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IPI
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0000151 ubiquitin ligase complex IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IEA
 cellular_componentGO:0097413 Lewy body IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / reaction
 ENSMUSG00000021774 P52482 / Ube2e1 / ubiquitin-conjugating enzyme E2E 1 / P51965*  / reaction
 ENSMUSG00000026254 Eif4e2 / Q8BMB3 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / O60573* / eukaryotic translation initiation factor 4E family member 2*  / complex / reaction
 ENSMUSG00000061130 Ppm1b / P36993 / protein phosphatase 1B, magnesium dependent, beta isoform / O75688* / protein phosphatase, Mg2+/Mn2+ dependent 1B*  / reaction
 ENSMUSG00000093661 Eif4e3 / Q9DBB5 / Eukaryotic translation initiation factor 4E type 3 / Q8N5X7* / eukaryotic translation initiation factor 4E family member 3*  / reaction
 ENSMUSG00000025278 Flnb / Q80X90 / Filamin-B / O75369*  / reaction
 ENSMUSG00000045983 Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*  / reaction
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / reaction
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / complex / reaction
 ENSMUSG00000059796 Eif4a1 / P60843 / Eukaryotic initiation factor 4A-I / P60842* / eukaryotic translation initiation factor 4A1*  / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / complex / reaction






 

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