ENSMUSG00000094973


Mus musculus

Features
Gene ID: ENSMUSG00000094973
  
Biological name :Gm8994
  
Synonyms : Gm8994
  
Possible biological names infered from orthology : EIF4A3 / eukaryotic translation initiation factor 4A3 / P38919
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G1
Gene start: 136327539
Gene end: 136329983
  
Corresponding Affymetrix probe sets: 10539177 (MoGene1.0st)   10541067 (MoGene1.0st)   10542369 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000133154
Ensembl peptide - ENSMUSP00000145166
Ensembl peptide - ENSMUSP00000144809
NCBI entrez gene - 668137     See in Manteia.
MGI - MGI:3644226
RefSeq - NM_001142734
RefSeq Peptide - NP_001136206
swissprot - E9PV04
swissprot - A0A0N4SVM5
Ensembl - ENSMUSG00000094973
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4a3ENSDARG00000102978Danio rerio
 EIF4A3ENSGALG00000008530Gallus gallus
 EIF4A3ENSG00000141543Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm5580 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*ENSMUSG0000010790698
Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*ENSMUSG0000002558096
Eif4a2 / P10630 / Mus musculus eukaryotic translation initiation factor 4A2 (Eif4a2), transcript variant 5, mRNA.ENSMUSG0000002288465
Eif4a1 / P60843 / Eukaryotic initiation factor 4A-I / P60842* / eukaryotic translation initiation factor 4A1*ENSMUSG0000005979665


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008380 RNA splicing IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
ISG15 antiviral mechanism
Transport of Mature mRNA derived from an Intron-Containing Transcript
Deadenylation of mRNA
mRNA Splicing - Major Pathway
mRNA 3-end processing
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078676 Casc3 / Q8K3W3 / Protein CASC3 / O15234* / cancer susceptibility 3*  / complex
 ENSMUSG00000028609 Magoh / P61327 / Protein mago nashi homolog / P61326* / mago homolog, exon junction complex core component*  / complex
 ENSMUSG00000038398 Upf3a / UPF3 regulator of nonsense transcripts homolog A (yeast) / Q9H1J1* / UPF3A, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000093661 Eif4e3 / Q9DBB5 / Eukaryotic translation initiation factor 4E type 3 / Q8N5X7* / eukaryotic translation initiation factor 4E family member 3*  / complex
 ENSMUSG00000043241 Upf2 / UPF2 regulator of nonsense transcripts homolog (yeast) / Q9HAU5* / UPF2, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000038374 Rbm8a / Q9CWZ3 / RNA-binding protein 8A / Q9Y5S9* / RNA binding motif protein 8A*  / complex
 ENSMUSG00000045983 Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*  / complex
 ENSMUSG00000025234 Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*  / reaction
 ENSMUSG00000026254 Eif4e2 / Q8BMB3 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / O60573* / eukaryotic translation initiation factor 4E family member 2*  / reaction
 ENSMUSG00000034681 Rnps1 / Q99M28 / RNA-binding protein with serine-rich domain 1 / Q15287*  / complex
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction
 ENSMUSG00000036572 Upf3b / UPF3 regulator of nonsense transcripts homolog B (yeast) / Q9BZI7* / UPF3B, regulator of nonsense mediated mRNA decay*  / complex






 

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