ENSGALG00000008530


Gallus gallus

Features
Gene ID: ENSGALG00000008530
  
Biological name :EIF4A3
  
Synonyms : EIF4A3 / Eukaryotic initiation factor 4A-III / Q5ZM36
  
Possible biological names infered from orthology : Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / eukaryotic translation initiation factor 4A3 / Gm5580 / Gm8994 / P38919 / Q91VC3
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 16425316
Gene end: 16432673
  
Corresponding Affymetrix probe sets: Gga.7844.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000038179
Ensembl peptide - ENSGALP00000064353
Ensembl peptide - ENSGALP00000061906
Ensembl peptide - ENSGALP00000061500
Ensembl peptide - ENSGALP00000061304
Ensembl peptide - ENSGALP00000044239
NCBI entrez gene - 416704     See in Manteia.
RefSeq - NM_001030649
RefSeq Peptide - NP_001025820
swissprot - A0A1L1RR66
swissprot - A0A1I7Q443
swissprot - A0A1D5NV66
swissprot - A0A1L1RZQ4
swissprot - Q5ZM36
swissprot - A0A1L1RRR4
Ensembl - ENSGALG00000008530
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4a3ENSDARG00000102978Danio rerio
 EIF4A3ENSG00000141543Homo sapiens
 Eif4a3ENSMUSG00000025580Mus musculus
 Gm5580ENSMUSG00000107906Mus musculus
 Gm8994ENSMUSG00000094973Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4A2 / Q8JFP1 / Eukaryotic initiation factor 4A-II ENSGALG0000000868461


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome ISS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008380 RNA splicing IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035145 exon-exon junction complex IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008143 poly(A) binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
Deadenylation of mRNA
mRNA Splicing - Major Pathway
mRNA 3-end processing
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010689 MAGOH / P50594 / Protein mago nashi homolog / Q96A72* / MAGOHB* / mago homolog B, exon junction complex core component*  / complex
 ENSGALG00000016815 UPF3A / UPF3A, regulator of nonsense mediated mRNA decay / Q9H1J1* / UPF3 regulator of nonsense transcripts homolog A (yeast)*  / complex
 ENSGALG00000009288 RNPS1 / RNA binding protein with serine rich domain 1 / Q15287* / Q99M28*  / complex
 ENSGALG00000031813 CASC3 / cancer susceptibility 3 / O15234* / Q8K3W3* / Protein CASC3 *  / complex
 ENSGALG00000033772 UPF2 / UPF2, regulator of nonsense mediated mRNA decay / Q9HAU5* / UPF2 regulator of nonsense transcripts homolog (yeast)*  / complex






 

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