ENSMUSG00000025330


Mus musculus

Features
Gene ID: ENSMUSG00000025330
  
Biological name :Padi4
  
Synonyms : Padi4 / Protein-arginine deiminase type-4 / Q9Z183
  
Possible biological names infered from orthology : peptidyl arginine deiminase 4 / Q9UM07
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 140745865
Gene end: 140774236
  
Corresponding Affymetrix probe sets: 10517791 (MoGene1.0st)   1422760_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026381
NCBI entrez gene - 18602     See in Manteia.
MGI - MGI:1338898
RefSeq - NM_011061
RefSeq - XM_006538633
RefSeq Peptide - NP_035191
swissprot - Q9Z183
Ensembl - ENSMUSG00000025330
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PADI4ENSG00000159339Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Padi1 / Q9Z185 / Protein-arginine deiminase type-1 / Q9ULC6* / peptidyl arginine deiminase 1*ENSMUSG0000002532955
Padi3 / Q9Z184 / Protein-arginine deiminase type-3 / Q9ULW8* / peptidyl arginine deiminase 3*ENSMUSG0000002532853
Padi2 / Q08642 / Protein-arginine deiminase type-2 / Q9Y2J8* / peptidyl arginine deiminase 2*ENSMUSG0000002892750
Padi6 / Q8K3V4 / Protein-arginine deiminase type-6 / Q6TGC4* / peptidyl arginine deiminase 6*ENSMUSG0000004093541


Protein motifs (from Interpro)
Interpro ID Name
 IPR004303  Protein-arginine deiminase
 IPR008972  Cupredoxin
 IPR013530  Protein-arginine deiminase, C-terminal
 IPR013732  Protein-arginine deiminase (PAD) N-terminal
 IPR013733  Protein-arginine deiminase (PAD), central domain
 IPR036556  Protein-arginine deiminase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006325 chromatin organization IMP
 biological_processGO:0006334 nucleosome assembly IMP
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0018101 protein citrullination ISO
 biological_processGO:0019546 arginine deiminase pathway IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0036413 histone H3-R26 citrullination IEA
 biological_processGO:0036414 histone citrullination IDA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004668 protein-arginine deiminase activity TAS
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016990 arginine deiminase activity IEA
 molecular_functionGO:0034618 arginine binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Chromatin modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+,Tg(TcraTcrb)1100Mjb/0,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Padi4tm1.2Kmow/Padi4tm1.2Kmow
Genetic Background: involves: C57BL/6 * SJL

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+,Tg(TcraTcrb)1100Mjb/0,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+,Tg(TcraTcrb)1100Mjb/0,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Padi4tm1.1Kmow/Padi4tm1.1Kmow
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+,Tg(TcraTcrb)1100Mjb/0,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Padi4tm1.1Kmow/Padi4tm1.1Kmow
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+,Tg(TcraTcrb)1100Mjb/0,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Padi4tm1.1Ywan/Padi4tm1.1Ywan
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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