Manteia

ENSMUSG00000026173

Mus musculus

Features

Gene ID:	ENSMUSG00000026173

Biological name :	Plcd4

Synonyms :	phospholipase C, delta 4 / Plcd4 / Q8K3R3

Possible biological names infered from orthology :	Q9BRC7

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	C3
Gene start:	74542888
Gene end:	74567794

Corresponding Affymetrix probe sets:	10347398 (MoGene1.0st) 1432927_at (Mouse Genome 430 2.0 Array) 1432928_at (Mouse Genome 430 2.0 Array) 1437030_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000121732 Ensembl peptide - ENSMUSP00000109379 Ensembl peptide - ENSMUSP00000115322 Ensembl peptide - ENSMUSP00000027362 Ensembl peptide - ENSMUSP00000064413 Ensembl peptide - ENSMUSP00000109376 Ensembl peptide - ENSMUSP00000109378 NCBI entrez gene - 18802 See in Manteia. MGI - MGI:107469 RefSeq - XM_017319346 RefSeq - NM_001081456 RefSeq - NM_148937 RefSeq - XM_006495788 RefSeq - XM_006495789 RefSeq - XM_006495790 RefSeq - XM_017319345 RefSeq - XM_006495783 RefSeq - XM_006495784 RefSeq - XM_006495785 RefSeq - XM_006495786 RefSeq - XM_006495787 RefSeq Peptide - NP_001074925 RefSeq Peptide - NP_683739 swissprot - Q8K3R3 swissprot - D6RGN2 Ensembl - ENSMUSG00000026173

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*	ENSMUSG00000010660	41
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*	ENSMUSG00000020937	41
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*	ENSMUSG00000029055	36
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*	ENSMUSG00000038910	36
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*	ENSMUSG00000036834	35
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*	ENSMUSG00000038349	33
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*	ENSMUSG00000030230	31
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*	ENSMUSG00000024960	30
Plcb4 / phospholipase C, beta 4 / Q15147*	ENSMUSG00000039943	30
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*	ENSMUSG00000040061	30
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*	ENSMUSG00000051177	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR000008	C2 domain
IPR000909	Phosphatidylinositol-specific phospholipase C, X domain
IPR001192	Phosphoinositide phospholipase C family
IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849	Pleckstrin homology domain
IPR002048	EF-hand domain
IPR011992	EF-hand domain pair
IPR011993	PH-like domain superfamily
IPR015359	Phosphoinositide-specific phospholipase C, EF-hand-like domain
IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
IPR028387	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
IPR035892	C2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007340	acrosome reaction	IMP
biological_process	GO:0016042	lipid catabolic process	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0046488	phosphatidylinositol metabolic process	TAS
cellular_component	GO:0005622	intracellular	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031965	nuclear membrane	ISO
molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	IEA
molecular_function	GO:0004629	phospholipase C activity	TAS
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0008081	phosphoric diester hydrolase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Synthesis of IP3 and IP4 in the cytosol

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0004542	impaired acrosome reaction	"abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0004543	abnormal sperm physiology	"anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr