Manteia

ENSMUSG00000026173

Mus musculus

Features

Gene ID:	ENSMUSG00000026173

Biological name :	Plcd4

Synonyms :	phospholipase C, delta 4 / Plcd4 / Q8K3R3

Possible biological names infered from orthology :	Q9BRC7

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	C3
Gene start:	74542888
Gene end:	74567794

Corresponding Affymetrix probe sets:	10347398 (MoGene1.0st) 1432927_at (Mouse Genome 430 2.0 Array) 1432928_at (Mouse Genome 430 2.0 Array) 1437030_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000121732 Ensembl peptide - ENSMUSP00000109379 Ensembl peptide - ENSMUSP00000115322 Ensembl peptide - ENSMUSP00000027362 Ensembl peptide - ENSMUSP00000064413 Ensembl peptide - ENSMUSP00000109376 Ensembl peptide - ENSMUSP00000109378 NCBI entrez gene - 18802 See in Manteia. MGI - MGI:107469 RefSeq - XM_017319346 RefSeq - NM_001081456 RefSeq - NM_148937 RefSeq - XM_006495788 RefSeq - XM_006495789 RefSeq - XM_006495790 RefSeq - XM_017319345 RefSeq - XM_006495783 RefSeq - XM_006495784 RefSeq - XM_006495785 RefSeq - XM_006495786 RefSeq - XM_006495787 RefSeq Peptide - NP_001074925 RefSeq Peptide - NP_683739 swissprot - Q8K3R3 swissprot - D6RGN2 Ensembl - ENSMUSG00000026173

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*	ENSMUSG00000010660	41
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*	ENSMUSG00000020937	41
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*	ENSMUSG00000029055	36
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*	ENSMUSG00000038910	36
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*	ENSMUSG00000036834	35
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*	ENSMUSG00000038349	33
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*	ENSMUSG00000030230	31
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*	ENSMUSG00000024960	30
Plcb4 / phospholipase C, beta 4 / Q15147*	ENSMUSG00000039943	30
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*	ENSMUSG00000040061	30
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*	ENSMUSG00000051177	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR000008	C2 domain
IPR000909	Phosphatidylinositol-specific phospholipase C, X domain
IPR001192	Phosphoinositide phospholipase C family
IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849	Pleckstrin homology domain
IPR002048	EF-hand domain
IPR011992	EF-hand domain pair
IPR011993	PH-like domain superfamily
IPR015359	Phosphoinositide-specific phospholipase C, EF-hand-like domain
IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
IPR028387	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
IPR035892	C2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007340	acrosome reaction	IMP
biological_process	GO:0016042	lipid catabolic process	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0046488	phosphatidylinositol metabolic process	TAS
cellular_component	GO:0005622	intracellular	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031965	nuclear membrane	ISO
molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	IEA
molecular_function	GO:0004629	phospholipase C activity	TAS
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0008081	phosphoric diester hydrolase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Synthesis of IP3 and IP4 in the cytosol

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0004542	impaired acrosome reaction	"abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0004543	abnormal sperm physiology	"anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr