ENSMUSG00000030230


Mus musculus

Features
Gene ID: ENSMUSG00000030230
  
Biological name :Plcz1
  
Synonyms : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Plcz1 / Q8K4D7
  
Possible biological names infered from orthology : phospholipase C zeta 1 / Q86YW0
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G2
Gene start: 139989673
Gene end: 140041457
  
Corresponding Affymetrix probe sets: 10548957 (MoGene1.0st)   1422658_at (Mouse Genome 430 2.0 Array)   1432405_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121908
Ensembl peptide - ENSMUSP00000032356
Ensembl peptide - ENSMUSP00000117043
Ensembl peptide - ENSMUSP00000119121
NCBI entrez gene - 114875     See in Manteia.
MGI - MGI:2150308
RefSeq - XM_017321343
RefSeq - XM_006506899
RefSeq - XM_006506900
RefSeq - XM_006506901
RefSeq - XM_006506902
RefSeq - NM_054066
RefSeq Peptide - NP_473407
swissprot - D6RIP4
swissprot - D6RCJ4
swissprot - Q8K4D7
Ensembl - ENSMUSG00000030230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCZ1ENSGALG00000013123Gallus gallus
 PLCZ1ENSG00000139151Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*ENSMUSG0000001066039
Plcd4 / Q8K3R3 / phospholipase C, delta 4 / Q9BRC7*ENSMUSG0000002617338
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*ENSMUSG0000002093737
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*ENSMUSG0000003891037
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*ENSMUSG0000002905535
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*ENSMUSG0000003834935
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*ENSMUSG0000003683434
Plcb4 / phospholipase C, beta 4 / Q15147*ENSMUSG0000003994333
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*ENSMUSG0000002496032
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*ENSMUSG0000004006132
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*ENSMUSG0000005117730


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028395  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007343 egg activation IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0060470 positive regulation of cytosolic calcium ion concentration involved in egg activation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0045120 pronucleus IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0061827 sperm head IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IDA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0010314 phosphatidylinositol-5-phosphate binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Plcz1em2Jparr/Plcz1em2Jparr
Genetic Background: C57BL/6-Plcz1em2Jparr

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Plcz1em2Jparr/Plcz1em2Jparr
Genetic Background: C57BL/6-Plcz1em2Jparr

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Plcz1em2Jparr/Plcz1em2Jparr
Genetic Background: C57BL/6-Plcz1em2Jparr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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