ENSMUSG00000038349


Mus musculus

Features
Gene ID: ENSMUSG00000038349
  
Biological name :Plcl1
  
Synonyms : Inactive phospholipase C-like protein 1 / Plcl1 / Q3USB7
  
Possible biological names infered from orthology : phospholipase C like 1 (inactive) / Q15111
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.2
Gene start: 55405921
Gene end: 55754285
  
Corresponding Affymetrix probe sets: 10346330 (MoGene1.0st)   1443974_at (Mouse Genome 430 2.0 Array)   1445723_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037854
NCBI entrez gene - 227120     See in Manteia.
MGI - MGI:3036262
RefSeq - NM_001114663
RefSeq Peptide - NP_001108135
swissprot - Q3USB7
Ensembl - ENSMUSG00000038349
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcl1ENSDARG00000067676Danio rerio
 PLCL1ENSGALG00000008113Gallus gallus
 PLCL1ENSG00000115896Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*ENSMUSG0000003891063
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*ENSMUSG0000002905531
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*ENSMUSG0000003683430
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*ENSMUSG0000001066025
Plcd4 / Q8K3R3 / phospholipase C, delta 4 / Q9BRC7*ENSMUSG0000002617325
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*ENSMUSG0000002093724
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*ENSMUSG0000002496023
Plcb4 / phospholipase C, beta 4 / Q15147*ENSMUSG0000003994323
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*ENSMUSG0000005117723
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*ENSMUSG0000004006122
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*ENSMUSG0000003023021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028382  Inactive phospholipase C-like protein 1/2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IGI
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IMP
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:1900122 positive regulation of receptor binding IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0050811 GABA receptor binding TAS
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Svs2tm2Kemi/Svs2tm2Kemi,Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * DBA/2

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Btg2tm1Spo/Btg2tm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Krastm4Tyj/Kras+,Plcl1tm1.1Matk/Plcl1tm1.1Matk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Btg2tm1Spo/Btg2tm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Svs2tm2Kemi/Svs2tm2Kemi,Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * DBA/2

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Svs2tm2Kemi/Svs2tm2Kemi,Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * DBA/2

Allelic Composition: Plcl1tm1.1Matk/Plcl1tm1.1Matk
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Plcl1tm2.1Matk/Plcl1tm2.1Matk
Genetic Background: FVB.Cg-Plcl1tm2.1Matk

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Btg2tm1Spo/Btg2tm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Plcl1tm1.1Matk/Plcl1tm1.1Matk
Genetic Background: FVB.Cg-Plcl1tm1.1Matk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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